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Celiprolol

Product Name
Celiprolol
CAS No.
56980-93-9
Chemical Name
Celiprolol
Synonyms
Edsivo;Selectol;-diethyl-;celiptolol;CELIPROLOL;dl-Celiprolol;Celiprolol Base;(R,S)-Celiprolol;Racemic Celiprolol;Celiprolol USP/EP/BP
CBNumber
CB8411567
Molecular Formula
C20H33N3O4
Formula Weight
379.49
MOL File
56980-93-9.mol
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Celiprolol Property

Melting point:
110-112°
Boiling point:
586.5±50.0 °C(Predicted)
Density 
1.114±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform (slightly), Methanol (Slightly)
pka
pKa ~9.7 (Uncertain)
form 
Solid
color 
Yellow
Water Solubility 
22.9mg/L(22.5 ºC)
CAS DataBase Reference
56980-93-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C254503
Product name
Celiprolol
Packaging
5mg
Price
$125
Updated
2021/12/16
Usbiological
Product number
237337
Product name
Diethyl
Packaging
1ml
Price
$192
Updated
2021/12/16
Usbiological
Product number
446762
Product name
Diethyl
Packaging
100mg
Price
$305
Updated
2021/12/16
Usbiological
Product number
446765
Product name
Diethyl [
Packaging
100mg
Price
$319
Updated
2021/12/16
Usbiological
Product number
446763
Product name
Diethyl
Packaging
5g
Price
$403
Updated
2021/12/16
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Celiprolol Chemical Properties,Usage,Production

Originator

Selectol,Chemie Linz,Austria,1983

Uses

Celiprolol is an intermediate in the synthesis of Celiprolol Hydrochloride (C254500). Celiprolol is a cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.

Definition

ChEBI: 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea is an aromatic ketone.

Manufacturing Process

3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4- hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking up the residue in chloroform and evaporating the latter, is obtained in a crystalline form. Melting point: 160°-162°C. After reaction of the product in alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)- propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and this, in turn, is reacted with excess tert-butylamine in aqueous solution at room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)- propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C.

Therapeutic Function

Beta-adrenergic blocker

Celiprolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Celiprolol Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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70
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Baoji Guokang Healthchem co.,ltd
Tel
+8615604608665 15604608665
Email
dominicguo@gk-bio.com
Country
CHINA
ProdList
9414
Advantage
58
Tel
58896805
Email
7993601name@qq.com
Country
CHINA
ProdList
15092
Advantage
58
Guangzhou PI PI Biotech Inc
Tel
020-81716320 +86-13602409664
Fax
020-81716319
Email
Sales@pipitech.com
Country
China
ProdList
3633
Advantage
55

56980-93-9, CeliprololRelated Search:


  • celiptolol
  • -diethyl-
  • n’-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-n,n-di
  • 3-[3-acetyl-4-(2-hydroxy-3-tert-butylamino-propoxy)-phenyl]-1,1-diethyl-urea
  • CELIPROLOL
  • Celiprolol Base
  • CELIPROLOLHYDROCHLORIDE(SUBJECTTOPANTENTFREE)
  • (R,S)-Celiprolol
  • dl-Celiprolol
  • Racemic Celiprolol
  • Selectol
  • Urea, N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-
  • rac-1,1-Diethyl-3-[3-acetyl-4-[(R*)-2-hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]phenyl]urea
  • rac-3-[3-Acetyl-4-[(R*)-3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea
  • Celiprolol USP/EP/BP
  • CeliprololQ: What is Celiprolol Q: What is the CAS Number of Celiprolol
  • Edsivo
  • 56980-93-9
  • 56980-93-3
  • C20H33N3O4