Celiprolol
- Product Name
- Celiprolol
- CAS No.
- 56980-93-9
- Chemical Name
- Celiprolol
- Synonyms
- Edsivo;Selectol;-diethyl-;celiptolol;CELIPROLOL;dl-Celiprolol;Celiprolol Base;(R,S)-Celiprolol;Racemic Celiprolol;Celiprolol USP/EP/BP
- CBNumber
- CB8411567
- Molecular Formula
- C20H33N3O4
- Formula Weight
- 379.49
- MOL File
- 56980-93-9.mol
Celiprolol Property
- Melting point:
- 110-112°
- Boiling point:
- 586.5±50.0 °C(Predicted)
- Density
- 1.114±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (slightly), Methanol (Slightly)
- pka
- pKa ～9.7 (Uncertain)
- form
- Solid
- color
- Yellow
- Water Solubility
- 22.9mg/L(22.5 ºC)
- CAS DataBase Reference
- 56980-93-9(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- C254503
- Product name
- Celiprolol
- Packaging
- 5mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 237337
- Product name
- Diethyl
- Packaging
- 1ml
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 446762
- Product name
- Diethyl
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 446765
- Product name
- Diethyl [
- Packaging
- 100mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- 446763
- Product name
- Diethyl
- Packaging
- 5g
- Price
- $403
- Updated
- 2021/12/16
Celiprolol Chemical Properties,Usage,Production
Originator
Selectol,Chemie Linz,Austria,1983
Uses
Celiprolol is an intermediate in the synthesis of Celiprolol Hydrochloride (C254500). Celiprolol is a cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.
Definition
ChEBI: 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea is an aromatic ketone.
Manufacturing Process
3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4- hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking up the residue in chloroform and evaporating the latter, is obtained in a crystalline form. Melting point: 160°-162°C. After reaction of the product in alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)- propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and this, in turn, is reacted with excess tert-butylamine in aqueous solution at room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)- propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C.
Therapeutic Function
Beta-adrenergic blocker
Celiprolol Preparation Products And Raw materials
Raw materials
Preparation Products
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