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Propranolol hydrochloride

Product Name
Propranolol hydrochloride
CAS No.
318-98-9
Chemical Name
Propranolol hydrochloride
Synonyms
PROPRANOLOL HCL;inderal;inderol;anaprilin;Dibudinate;InnoPran XL;kemi;Nedis;oposim;tesnol
CBNumber
CB5112834
Molecular Formula
C16H22ClNO2
Formula Weight
295.8
MOL File
318-98-9.mol
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Propranolol hydrochloride Property

Melting point:
163-165 °C(lit.)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
powder
color 
white
Water Solubility 
SOLUBLE
Merck 
14,7840
BRN 
4164259
BCS Class
1
InChIKey
ZMRUPTIKESYGQW-UHFFFAOYSA-N
CAS DataBase Reference
318-98-9(CAS DataBase Reference)
EPA Substance Registry System
Propranolol hydrochloride (318-98-9)
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Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
22-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
UB7525000
10
HazardClass 
IRRITANT
HS Code 
29221990
Hazardous Substances Data
318-98-9(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P-055
Product name
Propranolol hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$36.6
Updated
2024/03/01
Sigma-Aldrich
Product number
40543
Product name
(±)-Propranolol hydrochloride
Purity
analytical standard
Packaging
100mg
Price
$83.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1576005
Product name
Propranolol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
H26645
Product name
(±)-Propranolol hydrochloride, 99%
Packaging
5g
Price
$82.4
Updated
2024/03/01
Alfa Aesar
Product number
H26645
Product name
(±)-Propranolol hydrochloride, 99%
Packaging
25g
Price
$257
Updated
2024/03/01
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Propranolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White to Light-Yellow Cyrstalline Solid

Uses

β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

For the prophylaxis of migraine

Uses

Propranolol, a β-adrenergic blocker, is most commonly used to reduce blood pressure; treatment of over-active thyroid and some types of tremor; prevention of migraine headaches and some heart-rhythm problems; used to decrease the number of angina attacks (pain from an inadequate oxygen supply to the heart); used after a heart attack to prevent further damage to the heart.

Uses

(±)-Propranolol hydrochloride has been used:

  • to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
  • as a non-selective β- receptor blocker to reduce the arrhythmogenic events
  • to study its effect on oxygen-induced retinopathy in mice

brand name

Inderal (Wyeth); Innopran (Reliant).

General Description

Propranolol hydrochloride is easily soluble in ethanol and water.

Biochem/physiol Actions

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT1/5-HT2 serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

Clinical Use

Beta-adrenoceptor blocker:
Hypertension
Phaeochromocytoma
Angina
Arrhythmias
Anxiety
Migraine prophylaxis

Veterinary Drugs and Treatments

While propranolol is used for hypertension, migraine headache prophylaxis, and angina in human patients, it is used primarily in veterinary medicine for its antiarrhythmic effects. Dysrhythmias treated with propranolol include: atrial premature complexes, ventricular premature complexes, supraventricular premature complexes and tachyarrhythmias, ventricular or atrial tachyarrhythmias secondary to digitalis, atrial tachycardia secondary to Wolff-Parkinson-White (WPW) with normal QRS complexes, and atrial fibrillation (generally in combination with digoxin). Propranolol reportedly improves cardiac performance in animals with hypertrophic cardiomyopathy. It has been used to treat systemic hypertension and clinical signs associated with thyrotoxicosis and pheochromocytoma.

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect; risk of bupivacaine toxicity increased.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; concentration increased by propafenone and possibly dronedarone; increased risk of myocardial depression and bradycardia with flecainide; increased risk of lidocaine toxicity.
Antibacterials: metabolism increased by rifampicin.
Antidepressants: enhanced hypotensive effect with MAOIs; concentration increased by fluvoxamine; concentration of imipramine increased.
Antihypertensives; enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with mefloquine.
Antipsychotics enhanced hypotensive effect with phenothiazines; concentration of both drugs increased with chlorpromazine.
Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia.
Moxisylyte: possible severe postural hypotension.
Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.

Metabolism

Propranolol is subject to considerable hepatic-tissue binding and first-pass metabolism. It is metabolised in the liver to an active metabolite (4-hydroxypropranolol) and several inactive ones.
The metabolites and small amounts of unchanged drug are excreted in the urine.

storage

Store at RT

Propranolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Propranolol hydrochloride Suppliers

Zhongxiang Yaowei Biological Technology Co., Ltd.
Tel
15337241005 13260682861
Email
w13260682861@qq.com
Country
China
ProdList
2435
Advantage
58
Shandong Kanghong International Trade Co. LTD
Tel
0531-87229773 13156406177
Email
bianjianfenghg@163.com
Country
China
ProdList
92
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
400-880-2824 18107960669
Fax
18140514863
Email
79046690@qq.com
Country
China
ProdList
1267
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
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View Lastest Price from Propranolol hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Propranolol hydrochloride 318-98-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-07-01
Hebei Mojin Biotechnology Co.,Ltd
Product
Propranolol hydrochloride 318-98-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-10-22
Henan Fengda Chemical Co., Ltd
Product
Propranolol hydrochloride 318-98-9
Price
US $10.00-5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-19

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