Pramipexole dihydrochloride monohydrate
- Product Name
- Pramipexole dihydrochloride monohydrate
- CAS No.
- 191217-81-9
- Chemical Name
- Pramipexole dihydrochloride monohydrate
- Synonyms
- Pramipexole dihydrochloride monohydrate;Mirapex;Pramipexole for system suitability CRS;Pra-API;Pramipexole;Unii-3D867np06j;Pramipexole powder;PPX dihydrochloride;Pramipexole HCl hydrate;Pramipexole monohydrate
- CBNumber
- CB6969615
- Molecular Formula
- C10H20ClN3OS
- Formula Weight
- 265.8
- MOL File
- 191217-81-9.mol
Pramipexole dihydrochloride monohydrate Property
- Melting point:
- 290 °C(dec.)
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- color
- White to Almost white
- Merck
- 14,7705
- BCS Class
- 1
- InChI
- InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
- InChIKey
- ZTZQAWQFTIVKMU-DCFBZVEJNA-N
- SMILES
- NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r|
Safety
- WGK Germany
- 3
- RTECS
- DL3375000
- HS Code
- 2934200000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H336May cause drowsiness or dizziness
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- Y0001187
- Product name
- Pramipexole for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001187
- Price
- $150
- Updated
- 2024/03/01
- Product number
- PHR1598
- Product name
- Pramipexole dihydrochloride
- Packaging
- 500mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- P2073
- Product name
- Pramipexole Dihydrochloride Monohydrate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 100mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- P2073
- Product name
- Pramipexole Dihydrochloride Monohydrate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $152
- Updated
- 2024/03/01
- Product number
- Y0001266
- Product name
- Pramipexole dihydrochloride monohydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001266
- Price
- $150
- Updated
- 2024/03/01
Pramipexole dihydrochloride monohydrate Chemical Properties,Usage,Production
Description
Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Chemical Properties
White or almost white, crystalline powder.
Uses
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)
Definition
ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
brand name
Mirapex (Boehringer Ingelheim).
General Description
Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clinical Use
Parkinson’s disease
Symptomatic treatment of restless legs
Side effects
Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.
Drug interactions
Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.
Metabolism
Pramipexole undergoes <10% metabolism to inactive
metabolites.
More than 90% of a dose is excreted via renal tubular
secretion unchanged into the urine.
Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Pramipexole dihydrochloride monohydrate Suppliers
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View Lastest Price from Pramipexole dihydrochloride monohydrate manufacturers
- Product
- Pramipexole 191217-81-9
- Price
- US $2342.00-1800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-04-10
- Product
- Pramipexole dihydrochloride monohydrate 191217-81-9
- Price
- US $2160.00-2140.00/kilograms
- Min. Order
- 10kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-02-17
- Product
- Pramipexole 191217-81-9
- Price
- US $30.00/Box
- Min. Order
- 1Box
- Purity
- 99.99%
- Supply Ability
- 10000000000
- Release date
- 2023-12-06