ChemicalBook > CAS DataBase List > Pramipexole dihydrochloride monohydrate

Pramipexole dihydrochloride monohydrate

Product Name
Pramipexole dihydrochloride monohydrate
CAS No.
191217-81-9
Chemical Name
Pramipexole dihydrochloride monohydrate
Synonyms
Pramipexole dihydrochloride monohydrate;Mirapex;Pramipexole for system suitability CRS;Pra-API;Pramipexole;Unii-3D867np06j;Pramipexole powder;PPX dihydrochloride;Pramipexole HCl hydrate;Pramipexole monohydrate
CBNumber
CB6969615
Molecular Formula
C10H20ClN3OS
Formula Weight
265.8
MOL File
191217-81-9.mol
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Pramipexole dihydrochloride monohydrate Property

Melting point:
290 °C(dec.)
storage temp. 
2-8°C
solubility 
Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form 
Solid
color 
White to Almost white
Merck 
14,7705
BCS Class
1
InChI
InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
InChIKey
ZTZQAWQFTIVKMU-DCFBZVEJNA-N
SMILES
NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r|
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Safety

WGK Germany 
3
RTECS 
DL3375000
HS Code 
2934200000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001187
Product name
Pramipexole for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001187
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1598
Product name
Pramipexole dihydrochloride
Packaging
500mg
Price
$105
Updated
2024/03/01
TCI Chemical
Product number
P2073
Product name
Pramipexole Dihydrochloride Monohydrate
Purity
>98.0%(HPLC)(N)
Packaging
100mg
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
P2073
Product name
Pramipexole Dihydrochloride Monohydrate
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001266
Product name
Pramipexole dihydrochloride monohydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001266
Price
$150
Updated
2024/03/01
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Pramipexole dihydrochloride monohydrate Chemical Properties,Usage,Production

Description

Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

Chemical Properties

White or almost white, crystalline powder.

Uses

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)

Definition

ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.

brand name

Mirapex (Boehringer Ingelheim).

General Description

Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Clinical Use

Parkinson’s disease

Symptomatic treatment of restless legs

Side effects

Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.

Metabolism

Pramipexole undergoes <10% metabolism to inactive metabolites.
More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pramipexole dihydrochloride monohydrate Suppliers

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View Lastest Price from Pramipexole dihydrochloride monohydrate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Pramipexole hydrochloride 191217-81-9
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99% HPLC
Supply Ability
1000kg
Release date
2024-11-23
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Pramipexole dihydrochloride monohydrate 191217-81-9
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pramipexole 191217-81-9
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
99%-101%;BP
Supply Ability
100KGS
Release date
2021-07-16

191217-81-9, Pramipexole dihydrochloride monohydrateRelated Search:

HYDRAZINE Tris(hydroxymethyl)aminomethane PRAMIPEXOLE DIHYDROCHLORIDE,PRAMIPEXOLE HYDROCHLORIDE,PRAMIPEXOLE HCL Propranolol hydrochloride Propafenone Hydrochloride Lithium diisopropylamide ALTRENOGEST Benzothiazole 2-Mercaptobenzothiazole Chloral hydrate Propyl butyrate 2,2'-Dithiobis(benzothiazole) Glycine Propyl gallate 6-Aminocaproic acid D-Glucosamine hydrochloride Dihydrochloride PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE,PRAMIPEXOLE 2HCL MONOHYDRATE,Pramipexole

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  • Pramipexole Dihydrochloride MonohydrateQ: What is Pramipexole Dihydrochloride Monohydrate Q: What is the CAS Number of Pramipexole Dihydrochloride Monohydrate Q: What is the storage condition of Pramipexole Dihydrochloride Monohydrate
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  • 191217-81-9