ChemicalBook > CAS DataBase List > Pramipexole dihydrochloride monohydrate

Pramipexole dihydrochloride monohydrate

Product Name
Pramipexole dihydrochloride monohydrate
CAS No.
191217-81-9
Chemical Name
Pramipexole dihydrochloride monohydrate
Synonyms
Pramipexole dihydrochloride monohydrate;Mirapex;Pramipexole for system suitability CRS;Pra-API;Pramipexole;Unii-3D867np06j;Pramipexole powder;PPX dihydrochloride;Pramipexole HCl hydrate;Pramipexole monohydrate
CBNumber
CB6969615
Molecular Formula
C10H20ClN3OS
Formula Weight
265.8
MOL File
191217-81-9.mol
More
Less

Pramipexole dihydrochloride monohydrate Property

Melting point:
290 °C(dec.)
storage temp. 
2-8°C
solubility 
Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form 
Solid
color 
White to Almost white
optical activity
Consistent with structure
Merck 
14,7705
BCS Class
1
InChI
InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
InChIKey
ZTZQAWQFTIVKMU-DCFBZVEJNA-N
SMILES
NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r|
More
Less

Safety

WGK Germany 
3
RTECS 
DL3375000
HS Code 
2934200000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001266
Product name
Pramipexole dihydrochloride monohydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
5 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001187
Product name
Pramipexole for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR1598
Product name
Pramipexole dihydrochloride
Packaging
500mg
Price
$113
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001187
Product name
Pramipexole for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001187
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
P2073
Product name
Pramipexole Dihydrochloride Monohydrate
Purity
>98.0%(HPLC)(N)
Packaging
100mg
Price
$28
Updated
2025/07/31
More
Less

Pramipexole dihydrochloride monohydrate Chemical Properties,Usage,Production

Description

Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

Chemical Properties

White or almost white, crystalline powder.

Uses

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)

Definition

ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.

brand name

Mirapex (Boehringer Ingelheim).

General Description

Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Clinical Use

Parkinson’s disease

Symptomatic treatment of restless legs

Side effects

Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.

Metabolism

Pramipexole undergoes <10% metabolism to inactive metabolites.
More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pramipexole dihydrochloride monohydrate Suppliers

China 366 Czech Republic 1 Denmark 1 Germany 3 Greece 1 India 44 Israel 1 Italy 1 Japan 1 Malta 1 Spain 2 The Netherlands 1 United Kingdom 4 United States 24 Global 451
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Jinan Yuantai Pharmaceutical Co.,Ltd
Tel
0531-69959492 18366108822
Fax
0531-69959492
Email
85633700@qq.com
Country
China
ProdList
79
Advantage
55
Shandong Mingfeng Pharmaceutical and Technology Co. Ltd
Tel
-1345456643 15315114555
Fax
QQ:1345456643
Email
1345456643@qq.com
Country
China
ProdList
243
Advantage
58
Shandong Haiwo Biological Technology Co., Ltd.
Tel
0531-87586188 13046003282
Fax
0531-87586188
Email
3473674613@qq.com
Country
China
ProdList
51
Advantage
58
Jinan Yuantai Pharmaceutical Co.,Ltd
Tel
0531-69959492 18560053868
Fax
0531-88603458
Email
85349064@qq.com
Country
China
ProdList
144
Advantage
58
HONEST PHARM CO.,LTD.
Tel
0531-59840128 19353175568
Fax
QQ:3379530787
Email
zpy8217@163.com
Country
China
ProdList
465
Advantage
58
ABACHEM
Tel
13816002712
Fax
021-51159188
Email
liu_wj@abachem.com
Country
China
ProdList
45
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Wuhan Sunrise Technology Development Co., Ltd.
Tel
27-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
246
Advantage
62
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1618
Advantage
59
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Hangzhou Read Chemical Co., Ltd
Tel
15306818081 15372061639;
Fax
0571-87234255
Email
sales@freemindpharm.com
Country
China
ProdList
56
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
027-27-81302488 15972195220
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
1758
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Eastbang Pharmaceuticals Technology Co., Ltd.
Tel
+86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax
+86 (20) 39218032
Country
China
ProdList
454
Advantage
58
Zhengzhou Topcare Pharmaceutical Co.,Ltd.
Tel
0371-60942985
Fax
0371-60942986,qq1994339443
Country
China
ProdList
54
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Shandong Boluoda Biological Technology Co., Ltd.
Tel
0531-68652053 15863796298;
Email
2310993908@qq.com
Country
China
ProdList
2437
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Nanjing Lanya Chemical Co., Ltd.
Tel
+86-25-8331-5620
Fax
+86-25-8331-5629
Email
lanyachem@gmail.com
Country
China
ProdList
435
Advantage
55
Suzhou Huihe Pharmaceutical Co. Ltd.
Tel
86-0512-88819360,88985990
Fax
86-0512-86876095
Email
asynderm@163.com
Country
China
ProdList
90
Advantage
60
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
830
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Watson Biotechnology Co.,Ltd
Tel
027-59207879 1972026995 18140587686
Fax
QQ：1972026995
Email
sales@3600chem.com
Country
China
ProdList
4446
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
Struchem Co., Ltd.
Tel
0512-63009836 18994340901
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3981
Advantage
60
More
Less

View Lastest Price from Pramipexole dihydrochloride monohydrate manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
Pramipexole dihydrochloride monohydrate 191217-81-9
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pramipexole 191217-81-9
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
99%-101%;BP
Supply Ability
100KGS
Release date
2021-07-16
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Pramipexole dihydrochloride monohydrate 191217-81-9
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12

191217-81-9, Pramipexole dihydrochloride monohydrateRelated Search:

HYDRAZINE PRAMIPEXOLE DIHYDROCHLORIDE,PRAMIPEXOLE HYDROCHLORIDE,PRAMIPEXOLE HCL Propranolol hydrochloride Propafenone Hydrochloride Lithium diisopropylamide ALTRENOGEST Benzothiazole 2-Mercaptobenzothiazole Chloral hydrate Propyl butyrate 2,2'-Dithiobis(benzothiazole) Glycine Propyl gallate 6-Aminocaproic acid D-Glucosamine hydrochloride Tris(hydroxymethyl)aminomethane Dihydrochloride PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE,PRAMIPEXOLE 2HCL MONOHYDRATE,Pramipexole

  • Mirapex
  • (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HClH2Otetrahydrobenzothiazol
  • Mirapex,Sifrol,Mirapexin
  • Pramipexole dihydrochloride monohydrate
  • (6S)-N'-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride
  • (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate
  • Pramipexole
  • 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)-
  • Pramipexole HCl hydrate
  • Unii-3D867np06j
  • PraMipexole dihydrochloride Monohy
  • Pramipexole Dihydrochloride Monohydrate (200 mg)
  • 2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-N6-propyl-,hydrochloride,hydrate(1:2:1),(6S)-
  • PraMipexole dihydrochloride Monohyrate
  • PraMipexole dihydrochloride hydrate
  • (6S)- 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine,hydrochloride,hydrate (1:2:1)
  • PPX dihydrochloride
  • Pramipexole 2HCl Hydrate
  • Pramipexole (hydrochloride hydrate)
  • Pra-API
  • Pramipexole hydrochloride（Dihydrochloride monohydrate）
  • Pramipexole dihydrochloride monohydrate CRS
  • Pramipexole for system suitability CRS
  • PramipexoleDihydrochlorideMonohydrate&gt
  • Pramipexole Dihydrochloride Monohyd
  • 99.9%, Pramipexole Dihydrochloride Monohydrate?
  • Pramipexole Dihydrochloride Monohydrate DISCONTINUED, offer P700755 or P700750
  • Pramipexole dihydrochloride 1-hydrate
  • (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole -2,6-diamine hydrate dihydrochloride
  • Pramipexole monohydrate
  • Pramipexole powder
  • Pramipexole for system suitability (Y0001187)
  • Pramipexole Dihydrochloride MonohydrateQ: What is Pramipexole Dihydrochloride Monohydrate Q: What is the CAS Number of Pramipexole Dihydrochloride Monohydrate Q: What is the storage condition of Pramipexole Dihydrochloride Monohydrate
  • Pramipexole Dihydrochloride Monohydrate (1553859)
  • Pramipexole hydrochloride monohydrate
  • (S)-N6-Propyl-4,5,6,7-tetrahydrobenzodthiazol-2,6-diamine dihydrochloride hydrate
  • Pramipexole dihydrochloride hydrate, 10 mM in DMSO
  • Pramipexole 2HCl monohydrate - Bio-X ?
  • 191217-81-9
  • 91217-81-9
  • C10H17N3S2HClH2O
  • C10H17N3S2ClHH2O
  • Inhibitors
  • Pramipexole
  • 191217-81-9