Pramipexole dihydrochloride monohydrate

Product Name: Pramipexole dihydrochloride monohydrate
CAS No.: 191217-81-9
Chemical Name: Pramipexole dihydrochloride monohydrate
Synonyms: Pramipexole dihydrochloride monohydrate;Mirapex;Pramipexole for system suitability CRS;Pra-API;Pramipexole;Unii-3D867np06j;Pramipexole powder;PPX dihydrochloride;Pramipexole HCl hydrate;Pramipexole monohydrate
CBNumber: CB6969615
Molecular Formula: C10H20ClN3OS
Formula Weight: 265.8
MOL File: 191217-81-9.mol

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Pramipexole dihydrochloride monohydrate Property

Melting point:: 290 °C(dec.)
storage temp.: 2-8°C
solubility: Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form: Solid
color: White to Almost white
Merck: 14,7705
BCS Class: 1
InChI: InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
InChIKey: ZTZQAWQFTIVKMU-DCFBZVEJNA-N
SMILES: NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r|

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Safety

WGK Germany: 3
RTECS: DL3375000
HS Code: 2934200000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001187
Product name: Pramipexole for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001187
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1598
Product name: Pramipexole dihydrochloride
Packaging: 500mg
Price: $105
Updated: 2024/03/01

TCI Chemical

Product number: P2073
Product name: Pramipexole Dihydrochloride Monohydrate
Purity: >98.0%(HPLC)(N)
Packaging: 100mg
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: P2073
Product name: Pramipexole Dihydrochloride Monohydrate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $152
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001266
Product name: Pramipexole dihydrochloride monohydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001266
Price: $150
Updated: 2024/03/01

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Pramipexole dihydrochloride monohydrate Chemical Properties,Usage,Production

Description

Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

Chemical Properties

White or almost white, crystalline powder.

Uses

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)

Definition

ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.

brand name

Mirapex (Boehringer Ingelheim).

General Description

Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Clinical Use

Parkinson’s disease

Symptomatic treatment of restless legs

Side effects

Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.

Metabolism

Pramipexole undergoes <10% metabolism to inactive metabolites.
More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pramipexole dihydrochloride monohydrate Suppliers

China 358 Czech Republic 1 Denmark 1 Germany 3 Greece 1 India 42 Israel 1 Italy 1 Japan 1 Malta 1 Spain 2 The Netherlands 1 United Kingdom 4 United States 23 Global 440

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View Lastest Price from Pramipexole dihydrochloride monohydrate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Pramipexole hydrochloride 191217-81-9
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2024-11-23

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Pramipexole dihydrochloride monohydrate 191217-81-9
Price: US $1000.00-400.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-12

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pramipexole 191217-81-9
Price: US $0.00/Kg/Bag
Min. Order: 10g
Purity: 99%-101%;BP
Supply Ability: 100KGS
Release date: 2021-07-16

191217-81-9, Pramipexole dihydrochloride monohydrateRelated Search:

HYDRAZINE Tris(hydroxymethyl)aminomethane PRAMIPEXOLE DIHYDROCHLORIDE,PRAMIPEXOLE HYDROCHLORIDE,PRAMIPEXOLE HCL Propranolol hydrochloride Propafenone Hydrochloride Lithium diisopropylamide ALTRENOGEST Benzothiazole 2-Mercaptobenzothiazole Chloral hydrate Propyl butyrate 2,2'-Dithiobis(benzothiazole) Glycine Propyl gallate 6-Aminocaproic acid D-Glucosamine hydrochloride Dihydrochloride PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE,PRAMIPEXOLE 2HCL MONOHYDRATE,Pramipexole

Mirapex

(S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HClH2Otetrahydrobenzothiazol

Mirapex,Sifrol,Mirapexin

Pramipexole dihydrochloride monohydrate

(6S)-N'-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride

(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate

Pramipexole

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)-

Pramipexole HCl hydrate

Unii-3D867np06j

PraMipexole dihydrochloride Monohy

Pramipexole Dihydrochloride Monohydrate (200 mg)

2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-N6-propyl-,hydrochloride,hydrate(1:2:1),(6S)-

PraMipexole dihydrochloride Monohyrate

PraMipexole dihydrochloride hydrate

(6S)- 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine,hydrochloride,hydrate (1:2:1)

PPX dihydrochloride

Pramipexole 2HCl Hydrate

Pramipexole (hydrochloride hydrate)

Pra-API

Pramipexole hydrochloride（Dihydrochloride monohydrate）

Pramipexole dihydrochloride monohydrate CRS

Pramipexole for system suitability CRS

PramipexoleDihydrochlorideMonohydrate&gt

Pramipexole Dihydrochloride Monohyd

99.9%, Pramipexole Dihydrochloride Monohydrate?

Pramipexole Dihydrochloride Monohydrate DISCONTINUED, offer P700755 or P700750

Pramipexole dihydrochloride 1-hydrate

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole -2,6-diamine hydrate dihydrochloride

Pramipexole monohydrate

Pramipexole powder

Pramipexole for system suitability (Y0001187)

Pramipexole Dihydrochloride MonohydrateQ: What is Pramipexole Dihydrochloride Monohydrate Q: What is the CAS Number of Pramipexole Dihydrochloride Monohydrate Q: What is the storage condition of Pramipexole Dihydrochloride Monohydrate

Pramipexole Dihydrochloride Monohydrate (1553859)

Pramipexole hydrochloride monohydrate

(S)-N6-Propyl-4,5,6,7-tetrahydrobenzodthiazol-2,6-diamine dihydrochloride hydrate

191217-81-9

91217-81-9

C10H17N3S2HClH2O

C10H17N3S2ClHH2O

Inhibitors

Pramipexole

191217-81-9