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6-Aminocaproic acid

Description References
Product Name
6-Aminocaproic acid
CAS No.
60-32-2
Chemical Name
6-Aminocaproic acid
Synonyms
ACS;EACS;EACA;177jd;cy116;Hepin;Amikar;Amicar;CY 116;177 J.D
CBNumber
CB5223888
Molecular Formula
C6H13NO2
Formula Weight
131.17
MOL File
60-32-2.mol
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6-Aminocaproic acid Property

Melting point:
207-209 °C (dec.) (lit.)
Boiling point:
242.49°C (rough estimate)
Density 
1.042 g/cm3
vapor pressure 
<0.1 hPa (20 °C)
refractive index 
1.4870 (estimate)
Flash point:
207-209°C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
pka
4.373(at 25℃)
form 
powder
color 
white
Odor
Odorless
PH
7.0-7.5 (50g/l, H2O, 20℃)
Water Solubility 
SOLUBLE
Merck 
14,432
BRN 
906872
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
CAS DataBase Reference
60-32-2(CAS DataBase Reference)
NIST Chemistry Reference
Hexanoic acid, 6-amino-(60-32-2)
EPA Substance Registry System
Hexanoic acid, 6-amino- (60-32-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
MO6300000
TSCA 
Yes
HS Code 
29224995
Hazardous Substances Data
60-32-2(Hazardous Substances Data)
Toxicity
LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00145
Product name
6-Aminohexanoic acid
Purity
for synthesis
Packaging
5 g
Price
$24.7
Updated
2021/03/22
Sigma-Aldrich
Product number
8.00145
Product name
6-Aminohexanoic acid
Purity
for synthesis
Packaging
250 g
Price
$57.35
Updated
2021/03/22
Sigma-Aldrich
Product number
A0420000
Product name
Aminocaproic acid
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
8.00145
Product name
6-Aminohexanoic acid
Purity
for synthesis
Packaging
1 kg
Price
$207.2
Updated
2021/03/22
Sigma-Aldrich
Product number
07260
Product name
6-Aminohexanoic acid
Purity
≥98.5% (NT)
Packaging
100g
Price
$115
Updated
2021/03/22
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6-Aminocaproic acid Chemical Properties,Usage,Production

Description

6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease.

References

https://pubchem.ncbi.nlm.nih.gov/compound/6-aminohexanoic_acid#section=Pharmacology-and-Biochemistry
https://en.wikipedia.org/wiki/Aminocaproic_acid

Chemical Properties

white crystalline powder

Originator

Epsilon,Roche,W. Germany,1962

Uses

hemostatic

Uses

6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.

Uses

Propylparaben Food preservative

Uses

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Definition

ChEBI: An amino-acid anion that is the conjugate base of 6-aminohexanoic acid.

Manufacturing Process

5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.

brand name

Amicar (Xanodyne).

Therapeutic Function

Antifibrinolytic

Mechanism of action

Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.

Safety Profile

Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.

Chemical Synthesis

Aminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam at high temperature.

Veterinary Drugs and Treatments

Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.

6-Aminocaproic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Aminocaproic acid Suppliers

Chengdu Chuanke Fine Chemicals C.,Ltd.
Tel
+86 (28) 68626087 ;+86-28-85405627
Fax
+86-28-85408898
Email
customertwo@ckfc.asia
Country
China
ProdList
28
Advantage
62
Chemspon Bio-Tech Co., Ltd
Tel
0571-88937695;0571-88937835
Fax
0571-88933015 QQ:1423821043
Email
sales@chemspon.com;sales@chemspon.com
Country
China
ProdList
218
Advantage
58
Wuhan Hongde Yuexin Pharmaceutical Technology Co., Ltd
Tel
027-83850368-
Fax
027-83850368
Email
366526171@qq.com
Country
China
ProdList
2002
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
2000
Advantage
65
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
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View Lastest Price from 6-Aminocaproic acid manufacturers

Hebei Crovell Biotech Co Ltd
Product
6-Aminocaproic Acid 60-32-2
Price
US $10.00/Kg/Drum
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2021-07-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-Aminocaproic acid 60-32-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101.0%; EP
Supply Ability
1000KGS
Release date
2021-06-05
Anhui Rencheng Technology Co., Ltd
Product
6-Aminocaproic acid 60-32-2
Price
US $10.00-100.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2020-12-18

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