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Propranolol hydrochloride

Product Name
Propranolol hydrochloride
CAS No.
318-98-9
Chemical Name
Propranolol hydrochloride
Synonyms
PROPRANOLOL HCL;inderal;inderol;anaprilin;Dibudinate;InnoPran XL;kemi;Nedis;oposim;tesnol
CBNumber
CB5112834
Molecular Formula
C16H22ClNO2
Formula Weight
295.8
MOL File
318-98-9.mol
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Propranolol hydrochloride Property

Melting point:
163-165 °C(lit.)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
powder
color 
white
Water Solubility 
SOLUBLE
Merck 
14,7840
BRN 
4164259
BCS Class
1
InChIKey
ZMRUPTIKESYGQW-UHFFFAOYSA-N
CAS DataBase Reference
318-98-9(CAS DataBase Reference)
EPA Substance Registry System
Propranolol hydrochloride (318-98-9)
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Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
22-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
UB7525000
10
HazardClass 
IRRITANT
HS Code 
29221990
Hazardous Substances Data
318-98-9(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P-055
Product name
Propranolol hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$36.6
Updated
2024/03/01
Sigma-Aldrich
Product number
40543
Product name
(±)-Propranolol hydrochloride
Purity
analytical standard
Packaging
100mg
Price
$83.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1576005
Product name
Propranolol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
H26645
Product name
(±)-Propranolol hydrochloride, 99%
Packaging
5g
Price
$82.4
Updated
2024/03/01
Alfa Aesar
Product number
H26645
Product name
(±)-Propranolol hydrochloride, 99%
Packaging
25g
Price
$257
Updated
2024/03/01
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Propranolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White to Light-Yellow Cyrstalline Solid

Uses

β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

For the prophylaxis of migraine

Uses

Propranolol, a β-adrenergic blocker, is most commonly used to reduce blood pressure; treatment of over-active thyroid and some types of tremor; prevention of migraine headaches and some heart-rhythm problems; used to decrease the number of angina attacks (pain from an inadequate oxygen supply to the heart); used after a heart attack to prevent further damage to the heart.

Uses

(±)-Propranolol hydrochloride has been used:

  • to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
  • as a non-selective β- receptor blocker to reduce the arrhythmogenic events
  • to study its effect on oxygen-induced retinopathy in mice

brand name

Inderal (Wyeth); Innopran (Reliant).

General Description

Propranolol hydrochloride is easily soluble in ethanol and water.

Biochem/physiol Actions

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT1/5-HT2 serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

Clinical Use

Beta-adrenoceptor blocker:
Hypertension
Phaeochromocytoma
Angina
Arrhythmias
Anxiety
Migraine prophylaxis

Veterinary Drugs and Treatments

While propranolol is used for hypertension, migraine headache prophylaxis, and angina in human patients, it is used primarily in veterinary medicine for its antiarrhythmic effects. Dysrhythmias treated with propranolol include: atrial premature complexes, ventricular premature complexes, supraventricular premature complexes and tachyarrhythmias, ventricular or atrial tachyarrhythmias secondary to digitalis, atrial tachycardia secondary to Wolff-Parkinson-White (WPW) with normal QRS complexes, and atrial fibrillation (generally in combination with digoxin). Propranolol reportedly improves cardiac performance in animals with hypertrophic cardiomyopathy. It has been used to treat systemic hypertension and clinical signs associated with thyrotoxicosis and pheochromocytoma.

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect; risk of bupivacaine toxicity increased.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; concentration increased by propafenone and possibly dronedarone; increased risk of myocardial depression and bradycardia with flecainide; increased risk of lidocaine toxicity.
Antibacterials: metabolism increased by rifampicin.
Antidepressants: enhanced hypotensive effect with MAOIs; concentration increased by fluvoxamine; concentration of imipramine increased.
Antihypertensives; enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with mefloquine.
Antipsychotics enhanced hypotensive effect with phenothiazines; concentration of both drugs increased with chlorpromazine.
Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia.
Moxisylyte: possible severe postural hypotension.
Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.

Metabolism

Propranolol is subject to considerable hepatic-tissue binding and first-pass metabolism. It is metabolised in the liver to an active metabolite (4-hydroxypropranolol) and several inactive ones.
The metabolites and small amounts of unchanged drug are excreted in the urine.

storage

Store at RT

Propranolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Propranolol hydrochloride Suppliers

Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
Advantage
60
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View Lastest Price from Propranolol hydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Propranolol hydrochloride 318-98-9
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-11
Hebei Duling International Trade Co. LTD
Product
Propranolol hydrochloride 318-98-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2022-10-10
Shaanxi Dideu Medichem Co. Ltd
Product
Propranolol hydrochloride 318-98-9
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08

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