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Propranolol hydrochloride

Product Name
Propranolol hydrochloride
CAS No.
318-98-9
Chemical Name
Propranolol hydrochloride
Synonyms
kemi;Nedis;oposim;tesnol;Cinlol;Ciplar;Elbrol;Herzul;Ikopal;deralin
CBNumber
CB5112834
Molecular Formula
C16H22ClNO2
Formula Weight
295.8
MOL File
318-98-9.mol
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Propranolol hydrochloride Property

Melting point:
163-165 °C(lit.)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
powder
color 
white
Water Solubility 
SOLUBLE
Merck 
14,7840
BRN 
4164259
InChIKey
ZMRUPTIKESYGQW-UHFFFAOYSA-N
CAS DataBase Reference
318-98-9(CAS DataBase Reference)
EPA Substance Registry System
Propranolol hydrochloride (318-98-9)
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Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
22-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
UB7525000
10
HazardClass 
IRRITANT
HS Code 
29221990
Hazardous Substances Data
318-98-9(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P-055
Product name
Propranolol hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1 mL
Price
$28.8
Updated
2021/12/16
Sigma-Aldrich
Product number
40543
Product name
(±)-Propranolol hydrochloride
Purity
analytical standard
Packaging
100mg
Price
$64.8
Updated
2021/12/16
Sigma-Aldrich
Product number
1576005
Product name
Propranolol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/12/16
Sigma-Aldrich
Product number
PHR1308
Product name
Propranolol hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$70.4
Updated
2021/03/22
Sigma-Aldrich
Product number
P0884
Product name
(±)-Propranolol hydrochloride
Purity
≥99% (TLC), powder
Packaging
5g
Price
$133
Updated
2020/08/18
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Propranolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White to Light-Yellow Cyrstalline Solid

Uses

β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

For the prophylaxis of migraine

Uses

Propranolol, a β-adrenergic blocker, is most commonly used to reduce blood pressure; treatment of over-active thyroid and some types of tremor; prevention of migraine headaches and some heart-rhythm problems; used to decrease the number of angina attacks (pain from an inadequate oxygen supply to the heart); used after a heart attack to prevent further damage to the heart.

Uses

(±)-Propranolol hydrochloride has been used:
  • to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
  • as a non-selective β- receptor blocker to reduce the arrhythmogenic events
  • to study its effect on oxygen-induced retinopathy in mice

brand name

Inderal (Wyeth); Innopran (Reliant).

General Description

Propranolol hydrochloride is easily soluble in ethanol and water.

Biochem/physiol Actions

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT1/5-HT2 serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

Veterinary Drugs and Treatments

While propranolol is used for hypertension, migraine headache prophylaxis, and angina in human patients, it is used primarily in veterinary medicine for its antiarrhythmic effects. Dysrhythmias treated with propranolol include: atrial premature complexes, ventricular premature complexes, supraventricular premature complexes and tachyarrhythmias, ventricular or atrial tachyarrhythmias secondary to digitalis, atrial tachycardia secondary to Wolff-Parkinson-White (WPW) with normal QRS complexes, and atrial fibrillation (generally in combination with digoxin). Propranolol reportedly improves cardiac performance in animals with hypertrophic cardiomyopathy. It has been used to treat systemic hypertension and clinical signs associated with thyrotoxicosis and pheochromocytoma.

Propranolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Propranolol hydrochloride Suppliers

TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-3668-0489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28438
Advantage
80
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View Lastest Price from Propranolol hydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Propranolol hydrochloride 318-98-9
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-11
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Propranolol hydrochloride 318-98-9
Price
US $100.00/KG
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-11-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Propranolol hydrochloride 318-98-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-07-01

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