ChemicalBook > CAS DataBase List > Pyridaphenthion

Pyridaphenthion

Product Name
Pyridaphenthion
CAS No.
119-12-0
Chemical Name
Pyridaphenthion
Synonyms
Ofun;Ofnak;ORESTE;Ofnack;OFUNACK;cl12503;CL 12503;AC-12503;ent23,968;ENT 23,968
CBNumber
CB2292780
Molecular Formula
C14H17N2O4PS
Formula Weight
340.33
MOL File
119-12-0.mol
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Pyridaphenthion Property

Melting point:
54.5～56.5℃
Boiling point:
416.2±28.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
vapor pressure 
1.47×10-6 Pa (20 °C)
Flash point:
-4 °C
storage temp. 
APPROX 4°C
Water Solubility 
100mg l-1 （20°C）
pka
-2.09±0.40(Predicted)
BRN 
302741
CAS DataBase Reference
119-12-0(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorothioic acid, o-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) o,o-diethyl ester(119-12-0)
EPA Substance Registry System
Pyridaphenthion (119-12-0)
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Safety

Hazard Codes 
F,Xi,N,Xn
Risk Statements 
11-36-66-67-57-51/53-20/22
Safety Statements 
26-61-33-16
RIDADR 
2783
WGK Germany 
3
RTECS 
TF2275000
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
36895
Product name
Pyridaphenthion solution
Purity
10?μg/mL in ethyl acetate, PESTANAL?, analytical standard
Packaging
2ml
Price
$62
Updated
2022/05/15
Sigma-Aldrich
Product number
32538
Product name
Pyridaphenthion
Purity
PESTANAL?, analytical standard
Packaging
100mg
Price
$126
Updated
2022/05/15
AK Scientific
Product number
S535
Product name
Pyridaphenthion
Packaging
100mg
Price
$189
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0290691
Product name
PYRIDAPHENTHION
Purity
98.00%
Packaging
2.5G
Price
$1265
Updated
2021/12/16
AHH
Product number
MT-58329
Product name
Pyridaphenthion
Purity
98%
Packaging
2.5g
Price
$436
Updated
2021/12/16
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Pyridaphenthion Chemical Properties,Usage,Production

Description

Pyridaphenthion is a pale yellow solid, mp 54.5–56 ?C, vp 0.00147 mPa (20 ?C). Solubility in water is 100 mg/L (20 ?C). It is very soluble in acetone, methanol, and diethyl ether. Log Kow = 3.2.

Uses

Pyridaphenthion is used to control a wide range of chewing and sucking insects and mites in rice, vegetables, fruit and ornamentals.

Definition

ChEBI: Pyridaphenthion is an organic thiophosphate, an organothiophosphate insecticide and a pyridazinone. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is functionally related to a 6-hydroxy-2-phenylpyridazin-3-one.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. When heated to decomposition it emits very toxic fumes of SOx, POx, and NOx. Used to control chewing and suckmg insects on rice, fruits, vegetables, and cereals.

Metabolic pathway

Pyridaphentluon is photolytically transformed into the oxon and phenylmaleic hydrazide. In the mouse its metabolism involves oxidative dearylation, oxidative desulfuration to the oxon, de-ethylation and conjugation of phenylmaleic hydrazide produced as the ultimate product of stage I metabolism and is typical of many phosphorothioates. A marked difference between metabolism in mice and rats was shown, with rats excreting no desethylpyridaphenthion and excreting all of the phenyl-maleic hydrazide in an unconjugated form.

Metabolism

More than 70% of the dose administered to rats and mice was excreted within 24 h in the urine. The major metabolites excreted are phenylmaleic hydrazide and desethyl pyridafenthion-oxon. The half-life in soil is 11–24 d.

Degradation

The photolysis of pyridaphenthion on a glass slide irradiated with both short wavelength UV light and light of wavelength >300 nm was investigated by Tsao et al. (1989). Samples were irradiated for 48 hours at unrecorded light intensity as thin films spread on petri dishes or in solution in water, methanol or hexane under an oxygen atmosphere. The effects of photosensitisers was also assessed in the thin film experiments. The photoproducts were analysed by TLC, GC-MS and 1H NMR spectroscopy. Under thin film conditions pyridaphenthion was photodegraded more quickly with light >300 nm than by 254 um light and was degraded faster as a thin film than in solution. The main photoproducts from the glass surface and aqueous solution were pyridaphenthion oxon (2) and phenylmaleic hydrazide (3) (Scheme 1); the only other products were small amounts of polymers. Photosensitisers accelerated photolysis markedly with the most effective being a plant-derived natural product, cis-dehydromatricaria ester. It is notable that a simple chemical oxidation using 3-chloroperoxybenzoic acid gave the same two products, 2 and 3.

Toxicity evaluation

The acute oral LD50 for rats is 769–850 mg/kg. Inhalation LC50 (4 h) for rats is >1.13 mg/L air.

Pyridaphenthion Preparation Products And Raw materials

Raw materials

2-tert-Butyl-4,5-dichloro-3-2H-pyridazinone CIS-BUTENEDIOIC ANHYDRIDE THIOPHOSPHORYL CHLORIDE

Preparation Products

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China 87 Europe 4 France 1 Germany 2 India 1 Japan 3 Switzerland 1 United Kingdom 3 United States 15 Global 117
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View Lastest Price from Pyridaphenthion manufacturers

Career Henan Chemical Co
Product
Pyridaphenthion 119-12-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10tons
Release date
2020-01-20

119-12-0, PyridaphenthionRelated Search:

Pyridazine Clindamycin phosphate Phenyl salicylate PHENYL VALERATE Mefenpyr-diethyl Diethyl oxalate Ethylene glycol diethyl ether SULPHOSUCCINIC ACID ESTER Diethyl malonate Diphenylthiocarbazide Diphenyl ether Tris(2-chloroethyl) phosphate Celiprolol Phenylacetic acid 3-HYDROXY-1-PHENYL-6-PYRIDAZONE O,O,O-TRIETHYLPHOSPHOROTHIOATE 3-HYDROXY-1-METHYLPYRIDAZIN-6(1H)-ONE Diethyl ether

  • PYRIDAPHENTHION
  • OFUNACK
  • ORESTE
  • 3(2H)-Pyridazinone, 6-hydroxy-2-phenyl-, O-ester with O,O-diethyl phosphorothioate
  • 3(2h)-pyridazinone,6-hydroxy-2-phenyl-,o-esterwitho,o-diethylphosphoroth
  • American cyanamid 12,503
  • americancyanamid12,503
  • CL 12503
  • cl12503
  • DiethylO-(2,3-dihydro-3-oxo-2-phenyl-6-pyridazinyl)phosphorothioate
  • ENT 23,968
  • ent23,968
  • Ofunack(TM)
  • O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl)O,O-diethylphosphorothioate
  • O-(1,6-Dihydro-6-oxo-1-phenylpyridazin-3-yl) O,O-diethyl phosphorothioate
  • o-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl)o,o-diethylphosphorothioate
  • O,O-Diethyl O-(2,3-dihydro-3-oxo-2-phenyl-6-pyridazinyl)phosphorothioate
  • o,o-Diethyl o-(6-oxo-1-phenyl-1,6-dihydro-3-pyridazinyl) thiophosphate
  • o,o-diethylo-(2,3-dihydro-3-oxo-2-phenyl-6-pyridazinyl)phosphorothioate
  • O,O-Diethylphosphorothioate, O-ester with 6-hydroxy-2-phenyl-3(2H)-pyridazinone
  • o,o-diethylphosphorothioate,o-esterwith6-hydroxy-2-phenyl-3(2h)-pyridazino
  • Ofnack
  • Ofnak
  • Ofun
  • ofunack,e.c.(20%)
  • Phosphorothioic acid, O,O-diethyl ester, O-ester with 6-hydroxy-2-phenyl-3(2H)pyridazinone
  • Phosphorothioicacid,esters,O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl)-O,O-diethylester
  • phosphorothioicacid,o,o-diethylester,o-esterwith6-hydroxy-2-phenyl-3(2h)p
  • Pyridafenthion
  • pyridiphenthion
  • yridazinone
  • O,O-diethyl O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl) thiophosphate
  • Pyridaphenthione
  • pyridaphenthio (jmaf)
  • O,O-Diethyl-O-(3-oxo-2-phenyldihydro-6-pyridazinyl)- phosphorodithionate
  • 6-Diethoxyphosphinothioyloxy-2-phenylpyridazin-3-one
  • O-(1,6-Dihydro-6-oxo-1-phenyl-3-pyridazinyl)phosphorothioic acid O,O-diethyl ester
  • O,O-Diethyl-O-thiophosphat
  • Pyridafethion
  • O-(1,6-Dihydro-6-oxo-1-phenylpyridazin-3-yl)-O,O-diethylphosphorothionate
  • Pyridaphenthion solution
  • Pyridaphenthion E.C.(20%)
  • O，O-dietyl-O-(2,3-dihydro-3-oxo-2-phenyl-dazine-6-yl) phosphorothionate
  • Pyridaphenthion Solution, 100ppm
  • AC-12503
  • Phosphorothioic acid O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl) O,O-diethyl
  • Thiophosphoric acid O,O-diethyl-O-(6-oxo-1-phenyl-1,6-dihydropyridazin-3-yl) ester
  • 6-diethoxythiophosphoryloxy-2-phenyl-pyridazin-3-one
  • Pyridahenthion
  • Pyridaphenthion 250mg [119-12-0]
  • Purity of Pyridaphenthione
  • O,O-diethyl O-(6-oxo-1-phenyl-1,6-dihydropyridazin-3-yl) phosphorothioate
  • PyridaphenthionSolution,100mg/L,1ml
  • Pyridaphenthion @100 μg/mL in MeOH
  • Pyridaphenthion@1000 μg/mL in Acetone
  • Phosphorothioic acid, O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) O,O-diethyl ester
  • PyridaphePyridaphenthionnthion
  • 4'-Tetramethoxyflavone