IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID

Product Name: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
CAS No.: 77112-53-9
Chemical Name: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
Synonyms: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
CBNumber: CB1248609
Molecular Formula: C7H5N3O2
Formula Weight: 163.13
MOL File: 77112-53-9.mol

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IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Property

Melting point:: 280 °C (decomp)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.07±0.41(Predicted)
Appearance: Off-white to light brown Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I495518
Product name: Imidazo[1,2-a]pyrazine-2-carboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 057562
Product name: Imidazo[1,2-a]pyrazine-2-carboxylic acid
Purity: 95%
Packaging: 1g
Price: $1008
Updated: 2021/12/16

AK Scientific

Product number: W8372
Product name: Imidazo[1,2-a]pyrazine-2-carboxylicacid
Packaging: 25g
Price: $1368
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0167227
Product name: IMIDAZO[1,2-ALPHA]PYRAZINE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1686.3
Updated: 2021/12/16

Chemenu

Product number: CM168532
Product name: Imidazo[1,2-a]pyrazine-2-carboxylicacid
Purity: 95%+
Packaging: 1g
Price: $54
Updated: 2021/12/16

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IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

77112-52-8

77112-53-9

Lithium chloride monohydrate (6.50 g, 0.156 mol) was added to ethyl imidazo[1,2-a]pyrazine-2-carboxylate (9.73 g, 0.05 mol) in a mixed ethanol/water (400 mL/100 mL) solvent and the reaction was stirred at room temperature for 8 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The pH of the reaction mixture was adjusted to 3-4 with aqueous 1 N hydrochloric acid under cooling in an ice bath and a solid was precipitated. The precipitate was collected by filtration and washed sequentially with acetone and dichloromethane. The filter cake was dried at 50 °C and the residual solvent was removed under reduced pressure to afford imidazo[1,2-a]pyrazine-2-carboxylic acid (7.69 g, 9.4 mmol) in pink solid powder form in 93.7% yield.

References

[1] Patent: CN103965194, 2016, B. Location in patent: Paragraph 0214-0216
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 2, p. 206 - 212
[3] Farmaco, Edizione Scientifica, 1981, vol. 36, # 1, p. 61 - 80

IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Suppliers

China 78 Czech Republic 1 Germany 1 India 3 Ukraine 1 United Kingdom 1 United States 17 Global 102

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77112-53-9, IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACIDRelated Search:

IMIDAZO[1,2-A]PYRAZINE IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID ETHYL ESTER 4,5-Imidazoledicarboxylic acid Imidazo[1,5-a]pyridine-6-carboxylic acid (9CI) 1H-Imidazole-2-carboxylic acid IMIDAZO[1,5-A]PYRIDINE-3-CARBALDEHYDE Imidazo[1,2-b]pyridazine-3-carboxaldehyde (9CI) Methyl imidazo[1,2-a]pyridine-5-carboxylate Imidazo[1,5-a]pyrazine Imidazo[1,2-a]pyridine-6-carbaldehyde IMidazo[1,2-b]pyridazine-3-carboxylic acid IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Imidazo[2,1-b][1,3,4]thiadiazole-6-carboxylic acid Imidazo[1,2-a]pyrimidine IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID Imidazo[1,2-b]pyridazine IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID

IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID

77112-53-9