IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Product Name: IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 64951-06-0
Chemical Name: IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethy imidazol[1,2-a]pyrimidine-2-carboxylate;ETHYL IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLATE;Ethyl iMidazol[1,2-a]pyriMidine-2-carboxylate;IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl Imidazo[1,2-A]Pyrimidine-2-Carboxylate(WXC03684);IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
CBNumber: CB4704706
Molecular Formula: C9H9N3O2
Formula Weight: 191.19
MOL File: 64951-06-0.mol

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IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 170-172°
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.98±0.30(Predicted)
Appearance: Off-white to yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: E919215
Product name: Ethylimidazo[1,2-a]pyrimidine-2-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 449656
Product name: Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Packaging: 100mg
Price: $305
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-6E
Product name: Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Packaging: 1g
Price: $64
Updated: 2021/12/16

AK Scientific

Product number: W7637
Product name: Ethyimidazol[1,2-a]pyrimidine-2-carboxylate
Packaging: 100mg
Price: $91
Updated: 2021/12/16

Matrix Scientific

Product number: 044211
Product name: Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Purity: >95%
Packaging: 500mg
Price: $721
Updated: 2021/12/16

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IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

109-12-6

70-23-5

64951-07-1

64951-06-0

The reaction mixture was heated to 75 °C and maintained for 16 hours using 2-aminopyrimidine (5 g, 52.6 mmol) and ethyl 3-bromopyruvate (90%, 7.35 mL, 52.6 mmol) dissolved in ethanol (80 mL). Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. Subsequently, the reaction mixture was diluted with dichloromethane (CH2Cl2) and saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was washed twice with saturated aqueous NaHCO3 and the aqueous layer was extracted three times with CH2Cl2. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated again under reduced pressure. The brown oil obtained was suspended in cold CH2Cl2 and filtered, and the filter cake was washed with cold CH2Cl2 to give ethyl imidazo[1,2-a]pyrimidine-2-carboxylate (3 g, 30%) as a light yellow oil. The mother liquor contained a mixture of ethyl imidazo[1,2-a]pyrimidine-2-carboxylate and ethyl imidazo[1,2-a]pyrimidine-3-carboxylate (6 g, 60%) as a black oil. The mixture was first purified by silica gel column chromatography and then recrystallized from ethyl acetate (EtOAc) to give ethyl imidazo[1,2-a]pyrimidine-3-carboxylate (2 g, 20%).

References

[1] Patent: WO2006/71752, 2006, A1. Location in patent: Page/Page column 83
[2] European Journal of Medicinal Chemistry, 1994, vol. 29, # 4, p. 279 - 286
[3] European Journal of Medicinal Chemistry, 1991, vol. 26, # 1, p. 13 - 18
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5620 - 5628
[5] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00266

IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Suppliers

China 97 France 1 Germany 1 India 1 Russia 2 Ukraine 1 United Kingdom 5 United States 15 Global 123

Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate 64951-06-0
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Shaanxi Dideu Medichem Co. Ltd

Product: IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER 64951-06-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER 64951-06-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

64951-06-0, IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTERRelated Search:

Imidazo[1,2-a]pyrimidine IMIDAZO[1,2-A]PYRIDIN-8-YLAMINE Imidazo[1,2-a]pyridin-8-ol (9CI) IMIDAZO[2,1-B]THIAZOL-6-YLMETHANOL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBALDEHYDE IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDINE-3-BORONIC ACID PINACOL ESTER Imidazo[1,2-a]pyridine-2-acetic acid ethyl ester C-IMIDAZO[1,5-A]PYRIDIN-1-YL-METHYLAMINE Imidazo[1,5-a]pyridine-1-carboxaldehyde (9CI) IMIDAZO[1,2-A]PYRIDINE-3-CARBONITRILE Imidazo[1,2-a]pyridine-6-carbaldehyde Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) Methyl imidazo[1,2-a]pyridine-7-carboxylate Imidazo[1,2-a]pyridine ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE IMIDAZO[1,2-A]PYRIDIN-2-YLMETHANOL Imidazo[1,2-b]pyridazin-3-ylamine

ETHYL IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLATE

IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Ethy imidazol[1,2-a]pyrimidine-2-carboxylate

Ethyl iMidazol[1,2-a]pyriMidine-2-carboxylate

Ethyl Imidazo[1,2-A]Pyrimidine-2-Carboxylate(WXC03684)

IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH

64951-06-0

4951-06-0

Heterocycle-Pyrimidine series