ChemicalBook > CAS DataBase List > IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER

IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Product Name
IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER
CAS No.
64951-06-0
Chemical Name
IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER
Synonyms
Ethy imidazol[1,2-a]pyrimidine-2-carboxylate;ETHYL IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLATE;Ethyl iMidazol[1,2-a]pyriMidine-2-carboxylate;IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl Imidazo[1,2-A]Pyrimidine-2-Carboxylate(WXC03684);IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
CBNumber
CB4704706
Molecular Formula
C9H9N3O2
Formula Weight
191.19
MOL File
64951-06-0.mol
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IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:
170-172°
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
1.98±0.30(Predicted)
Appearance
Off-white to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
E919215
Product name
Ethylimidazo[1,2-a]pyrimidine-2-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
449656
Product name
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Packaging
100mg
Price
$305
Updated
2021/12/16
Matrix Scientific
Product number
044211
Product name
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Purity
>95%
Packaging
500mg
Price
$721
Updated
2021/12/16
AK Scientific
Product number
W7637
Product name
Ethyimidazol[1,2-a]pyrimidine-2-carboxylate
Packaging
100mg
Price
$91
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-6E
Product name
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Packaging
1g
Price
$64
Updated
2021/12/16
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IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

109-12-6

70-23-5

64951-07-1

64951-06-0

The reaction mixture was heated to 75 °C and maintained for 16 hours using 2-aminopyrimidine (5 g, 52.6 mmol) and ethyl 3-bromopyruvate (90%, 7.35 mL, 52.6 mmol) dissolved in ethanol (80 mL). Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. Subsequently, the reaction mixture was diluted with dichloromethane (CH2Cl2) and saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was washed twice with saturated aqueous NaHCO3 and the aqueous layer was extracted three times with CH2Cl2. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated again under reduced pressure. The brown oil obtained was suspended in cold CH2Cl2 and filtered, and the filter cake was washed with cold CH2Cl2 to give ethyl imidazo[1,2-a]pyrimidine-2-carboxylate (3 g, 30%) as a light yellow oil. The mother liquor contained a mixture of ethyl imidazo[1,2-a]pyrimidine-2-carboxylate and ethyl imidazo[1,2-a]pyrimidine-3-carboxylate (6 g, 60%) as a black oil. The mixture was first purified by silica gel column chromatography and then recrystallized from ethyl acetate (EtOAc) to give ethyl imidazo[1,2-a]pyrimidine-3-carboxylate (2 g, 20%).

References

[1] Patent: WO2006/71752, 2006, A1. Location in patent: Page/Page column 83
[2] European Journal of Medicinal Chemistry, 1994, vol. 29, # 4, p. 279 - 286
[3] European Journal of Medicinal Chemistry, 1991, vol. 26, # 1, p. 13 - 18
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5620 - 5628
[5] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00266

IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate 64951-06-0
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Shaanxi Dideu Medichem Co. Ltd
Product
IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER 64951-06-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Career Henan Chemical Co
Product
IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER 64951-06-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

64951-06-0, IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTERRelated Search:

Imidazo[1,2-a]pyrimidine IMIDAZO[1,2-A]PYRIDIN-8-YLAMINE Imidazo[1,2-a]pyridin-8-ol (9CI) IMIDAZO[2,1-B]THIAZOL-6-YLMETHANOL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBALDEHYDE IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDINE-3-BORONIC ACID PINACOL ESTER Imidazo[1,2-a]pyridine-2-acetic acid ethyl ester C-IMIDAZO[1,5-A]PYRIDIN-1-YL-METHYLAMINE Imidazo[1,5-a]pyridine-1-carboxaldehyde (9CI) IMIDAZO[1,2-A]PYRIDINE-3-CARBONITRILE Imidazo[1,2-a]pyridine-6-carbaldehyde Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) Methyl imidazo[1,2-a]pyridine-7-carboxylate Imidazo[1,2-a]pyridine ETHYL IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLATE IMIDAZO[1,2-A]PYRIDIN-2-YLMETHANOL Imidazo[1,2-b]pyridazin-3-ylamine

  • ETHYL IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLATE
  • IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER
  • Ethy imidazol[1,2-a]pyrimidine-2-carboxylate
  • Ethyl iMidazol[1,2-a]pyriMidine-2-carboxylate
  • Ethyl Imidazo[1,2-A]Pyrimidine-2-Carboxylate(WXC03684)
  • IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
  • 64951-06-0
  • 4951-06-0
  • Heterocycle-Pyrimidine series