Methyl imidazo[1,2-a]pyridine-7-carboxylate
- Product Name
- Methyl imidazo[1,2-a]pyridine-7-carboxylate
- CAS No.
- 86718-01-6
- Chemical Name
- Methyl imidazo[1,2-a]pyridine-7-carboxylate
- Synonyms
- 7-(Methoxycarbonyl)imidazo[1,2-a]pyridine;Methyl imidazo[1,2-a]pyridine-7-carboxylate;methyl H-imidazo[1,2-a]pyridine-7-carboxylate;Methylimidazo[1,2-a]pyridine-7-carboxylate,95%;7-imidazo[1,2-a]pyridinecarboxylic acid methyl ester;IMidazo[1,2-a]pyridine-7-carboxylic acid, Methyl ester
- CBNumber
- CB62463517
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 86718-01-6.mol
Methyl imidazo[1,2-a]pyridine-7-carboxylate Property
- Melting point:
- 133-135℃
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.67±0.50(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C9H8N2O2/c1-13-9(12)7-2-4-11-5-3-10-8(11)6-7/h2-6H,1H3
- InChIKey
- KYHRVKMXYXBEQN-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1C=CC(C(OC)=O)=C2
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M323828
- Product name
- Methylimidazo[1,2-a]pyridine-7-carboxylate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H23-1-Y0
- Product name
- Methyl imidazo[1,2-a]pyridine-7-carboxylate
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 056501
- Product name
- Methyl imidazo[1,2-a]pyridine-7-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- 056501
- Product name
- Methyl imidazo[1,2-a]pyridine-7-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- X7987
- Product name
- Methylimidazo[1,2-a]pyridine-7-carboxylate
- Packaging
- 25g
- Price
- $752
- Updated
- 2021/12/16
Methyl imidazo[1,2-a]pyridine-7-carboxylate Chemical Properties,Usage,Production
Synthesis
6937-03-7
2032-35-1
86718-01-6
General procedure for the synthesis of methyl imidazo[1,2-a]pyridine-7-carboxylate from methyl 2-aminoisonicotinate and bromoacetaldehyde diethyl acetal: A mixture of 2-bromo-1,1-diethoxyethane (6.20 mL, 41.2 mmol) and 35% aqueous HCl (0.82 mL, 26.8 mmol) in water (68 mL) was stirred for 2.5 hours. It was then heated at 80 °C and kept at that temperature and stirred for 1.5 hours. After the reaction mixture was cooled to 20 °C, sodium bicarbonate (NaHCO3, 4.49 g, 53.45 mmol) was added in four portions. Finally, methyl 2-aminoisonicotinate (5 g, 32.86 mmol) was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solid formed was collected by filtration, washed with water and dried in a vacuum oven to afford 5.15 g of methyl imidazo[1,2-a]pyridine-7-carboxylate as a brown solid in 89% yield.LRMS: m/z 177 (M + 1)+; retention time: 1.46 min (Method A).1H NMR (200 MHz, CDCl3) δ ppm : 3.97 (s, 3H), 7.27 (s, 1H), 7.42 (d, J = 6 Hz, 1H), 7.70 (s, 1H), 7.80 (s, 1H), 8.19 (d, J = 6 Hz, 1H), 8.37 (s, 1H).
References
[1] Patent: WO2010/43377, 2010, A1. Location in patent: Page/Page column 53-54
[2] Patent: WO2010/16005, 2010, A1. Location in patent: Page/Page column 118
[3] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
[4] Patent: US4962115, 1990, A
Methyl imidazo[1,2-a]pyridine-7-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl imidazo[1,2-a]pyridine-7-carboxylate manufacturers
- Product
- Methyl imidazo[1,2-a]pyridine-7-carboxylate 86718-01-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10