ChemicalBook > CAS DataBase List > IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID

IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID

Product Name
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
CAS No.
77112-53-9
Chemical Name
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
Synonyms
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
CBNumber
CB1248609
Molecular Formula
C7H5N3O2
Formula Weight
163.13
MOL File
77112-53-9.mol
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IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Property

Melting point:
280 °C (decomp)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-2.07±0.41(Predicted)
Appearance
Off-white to light brown Solid
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
I495518
Product name
Imidazo[1,2-a]pyrazine-2-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
057562
Product name
Imidazo[1,2-a]pyrazine-2-carboxylic acid
Purity
95%
Packaging
1g
Price
$1008
Updated
2021/12/16
AK Scientific
Product number
W8372
Product name
Imidazo[1,2-a]pyrazine-2-carboxylicacid
Packaging
25g
Price
$1368
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167227
Product name
IMIDAZO[1,2-ALPHA]PYRAZINE-2-CARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$1686.3
Updated
2021/12/16
Chemenu
Product number
CM168532
Product name
Imidazo[1,2-a]pyrazine-2-carboxylicacid
Purity
95%+
Packaging
1g
Price
$54
Updated
2021/12/16
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IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

77112-52-8

77112-53-9

Lithium chloride monohydrate (6.50 g, 0.156 mol) was added to ethyl imidazo[1,2-a]pyrazine-2-carboxylate (9.73 g, 0.05 mol) in a mixed ethanol/water (400 mL/100 mL) solvent and the reaction was stirred at room temperature for 8 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The pH of the reaction mixture was adjusted to 3-4 with aqueous 1 N hydrochloric acid under cooling in an ice bath and a solid was precipitated. The precipitate was collected by filtration and washed sequentially with acetone and dichloromethane. The filter cake was dried at 50 °C and the residual solvent was removed under reduced pressure to afford imidazo[1,2-a]pyrazine-2-carboxylic acid (7.69 g, 9.4 mmol) in pink solid powder form in 93.7% yield.

References

[1] Patent: CN103965194, 2016, B. Location in patent: Paragraph 0214-0216
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 2, p. 206 - 212
[3] Farmaco, Edizione Scientifica, 1981, vol. 36, # 1, p. 61 - 80

IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Suppliers

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77112-53-9, IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACIDRelated Search:

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  • IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
  • 77112-53-9