ChemicalBook > CAS DataBase List > IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Product Name
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
CAS No.
38922-77-9
Chemical Name
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
Synonyms
ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;2-(Ethoxycarbonyl)imidazo[1,2-a]pyridine;ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate;Ethyl imidazo[1,2-a]pyridine-2-carboxylate 97%;Ethyl imidazo[1,2-a]pyridine-2-carboxylate ,97%;Ethyl imidazo[1,2-a]pyridine-2-carboxylate;Imidazo-[1,2-A] pyridine-2-carboxylate ethyl ester;IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
CBNumber
CB9320369
Molecular Formula
C10H10N2O2
Formula Weight
190.2
MOL File
38922-77-9.mol
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IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:
79.5-83
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
3.28±0.50(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C10H10N2O2/c1-2-14-10(13)8-7-12-6-4-3-5-9(12)11-8/h3-7H,2H2,1H3
InChIKey
GNFACXDTRBVZJE-UHFFFAOYSA-N
SMILES
C12=NC(C(OCC)=O)=CN1C=CC=C2
CAS DataBase Reference
38922-77-9(CAS DataBase Reference)
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Safety

Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
737550
Product name
Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Purity
97%
Packaging
1g
Price
$101
Updated
2023/01/07
TRC
Product number
E919218
Product name
Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
E919218
Product name
Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
044881
Product name
Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Purity
>95%
Packaging
500mg
Price
$109
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK289695
Product name
Ethyl imidazo[1,2-a]pyridine-2-carboxylate
Purity
97%
Packaging
1g
Price
$47
Updated
2021/12/16
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IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-white to brown solid

Synthesis

504-29-0

70-23-5

38922-77-9

Step 1: Synthesis of ethyl imidazo[1,2-a]pyridine-2-carboxylate Under magnetic stirring, 3 g (31.9 mmol) of 2-aminopyridine was dissolved in 65 mL of tetrahydrofuran. 4.44 mL (31.9 mmol) of ethyl 3-bromopyruvate was added slowly and solid precipitate formation was observed. The resulting non-homogeneous mixture was heated to reflux and stirred continuously for 4 hours. Upon completion of the reaction, it was cooled to room temperature and the solid product was isolated by filtration. The solid was dissolved in 65 mL of ethanol and again heated to reflux and stirred for 16 hours. The reaction mixture was cooled to room temperature and the solids were separated by filtration. The filtrate was placed in an ice bath to promote crystallization of the product until the liquid phase remained clear. The crystallized product was collected by filtration and washed with 30 mL of diisopropyl ether. Finally, the product was dried in a vacuum desiccator to afford 5.14 g (84% yield) of ethyl imidazo[1,2-a]pyridine-2-carboxylate as a white powder. Product characterization: LC-MS showed m/z=191 (MH+); UV purity was 99% at 254 nm.1H NMR (300 MHz, DMSO) δ 8.95 (s, 1H), 8.84 (d, J=6.8 Hz, 1H), 7.98-7.80 (m, 2H), 7.46 (t, J=7.2 Hz, 1H), 4.43 ( q, J=7.1Hz, 2H), 1.35 (d, J=7.1Hz, 3H).

References

[1] ACS Combinatorial Science, 2018, vol. 20, # 3, p. 164 - 171
[2] Patent: US2015/182507, 2015, A1. Location in patent: Paragraph 0204; 0205
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 359 - 362
[4] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 216 - 231
[5] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Ethyl pyruvate Carbon tetrachloride Tetrahydrofuran 2-Aminopyridine

Preparation Products

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IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Suppliers

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View Lastest Price from IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers

Henan Fengda Chemical Co., Ltd
Product
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 38922-77-9
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-24
Career Henan Chemical Co
Product
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 38922-77-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 681
Release date
2019-09-01

38922-77-9, IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTERRelated Search:

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE IMIDAZO[1,2-A]PYRIDIN-8-YLAMINE Imidazo[1,2-a]pyridine IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Imidazo[1,2-b]pyridazine IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID Imidazo[1,2-a]pyridine-5-carboxylic acid (9CI) IMIDAZO[1,2-A]PYRAZINE Imidazo[1,2-a]pyrimidine Imidazo[1,2-a]pyridine-7-methanol (9CI) Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI) Imidazo[1,2-a]pyrazin-3-ylamine Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI) Imidazo[1,2-a]pyridine-6-carbaldehyde (1H-IMIDAZOL-2-YL)-METHANOL IMidazo[1,2-a]pyridine-3-aceticacid,ethylester

  • IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
  • ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE
  • Ethyl imidazo[1,2-a]pyridine-2-carboxylate 97%
  • Ethyl imidazo[1,2-a]pyridine-2-carboxylate ,97%
  • 2-(Ethoxycarbonyl)imidazo[1,2-a]pyridine
  • Imidazo-[1,2-A] pyridine-2-carboxylate ethyl ester
  • ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate
  • Ethyl imidazo[1,2-<i>a</i>]pyridine-2-carboxylate
  • 38922-77-9
  • Heterocycle-Pyridine series
  • Esters
  • Fused Ring Systems