5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE
- Product Name
- 5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE
- CAS No.
- 42951-71-3
- Chemical Name
- 5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE
- Synonyms
- 2-chloro-4,6-dimethyl-5-bromonicotinonitrile;5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE;5-Bromo-2-chloro-3-cyano-4,6-dimethylpyridine;5-Bromo-2-chloro-4,6-dimethylnicotinonitrile ,97%;5-bromo-2-chloro-4,6-dimethylpyridine-3-carbonitrile;3-Pyridinecarbonitrile, 5-bromo-2-chloro-4,6-dimethyl-
- CBNumber
- CB2354695
- Molecular Formula
- C8H6BrClN2
- Formula Weight
- 245.5
- MOL File
- 42951-71-3.mol
5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE Property
- Melting point:
- 106-108°C
- Boiling point:
- 320.1±37.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.79±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 044305
- Product name
- 5-Bromo-2-chloro-4,6-dimethylnicotinonitrile
- Purity
- >95%
- Packaging
- 500mg
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 044305
- Product name
- 5-Bromo-2-chloro-4,6-dimethylnicotinonitrile
- Purity
- >95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 044305
- Product name
- 5-Bromo-2-chloro-4,6-dimethylnicotinonitrile
- Purity
- >95%
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- X5158
- Product name
- 5-bromo-2-chloro-4,6-dimethylnicotinonitrile
- Packaging
- 10g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- HCH0024431
- Product name
- 5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $225.75
- Updated
- 2021/12/16
5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Synthesis
23819-87-6
42951-71-3
General procedure for the synthesis of 2-chloro-4,6-dimethyl-5-bromonicotinonitrile from 2-hydroxy-3-cyano-4,6-dimethyl-5-bromopyridine: To a solution of 5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (14 g, 61.7 mmol) in POCl3 (10 mL) was added phosphorus pentachloride (12.84 g, 61.7 mmol). The reaction mixture was heated to reflux and held for about 8 hours. Upon completion of the reaction, POCl3 was removed by distillation under reduced pressure. the residue was partitioned between dichloromethane (100 mL) and 5% aqueous sodium hydroxide solution (100 mL). The organic phases were combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was again dissolved in POCl3 (20 mL) and phosphorus pentachloride (13 g, 62.4 mmol) was added. The reaction mixture was heated to reflux and held for about 12 hours. Upon completion of the reaction, POCl3 was removed by distillation under reduced pressure. the residue was partitioned between dichloromethane (100 mL) and 5% aqueous sodium hydroxide solution (100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 5-bromo-2-chloro-4,6-dimethylnicotinonitrile (12 g, 79% yield). LCMS (Table 1, method d) retention time = 2.12 min; mass spectrum m/z = 246,248 (M + H).
References
[1] Journal of Organic Chemistry, 1984, vol. 49, # 26, p. 5237 - 5243
[2] Patent: WO2016/198908, 2016, A1. Location in patent: Page/Page column 76
[3] Biological and Pharmaceutical Bulletin, 2016, vol. 39, # 4, p. 473 - 483
5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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