3-BROMO-2,4-DIMETHYLPYRIDINE

Application

Product Name: 3-BROMO-2,4-DIMETHYLPYRIDINE
CAS No.: 27063-93-0
Chemical Name: 3-BROMO-2,4-DIMETHYLPYRIDINE
Synonyms: 3-BroMo-2,4-lutidine;3-BROMO-2,4-DIMETHYLPYRIDINE;3-Bromo-2,4-Dimethylpiperidine;PYRIDINE, 3-BROMO-2,4-DIMETHYL
CBNumber: CB02451679
Molecular Formula: C7H8BrN
Formula Weight: 186.05
MOL File: 27063-93-0.mol

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3-BROMO-2,4-DIMETHYLPYRIDINE Property

Boiling point:: 28-29 °C(Press: 40 Torr)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 4.25±0.18(Predicted)
Appearance: Off-white to light brown Solid-Liquid Mixture
CAS DataBase Reference: 27063-93-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B623690
Product name: 3-bromo-2,4-dimethylpyridine
Packaging: 30mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B623690
Product name: 3-bromo-2,4-dimethylpyridine
Packaging: 60mg
Price: $90
Updated: 2021/12/16

TRC

Product number: B623690
Product name: 3-bromo-2,4-dimethylpyridine
Packaging: 300mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0005492
Product name: 3-Bromo-2,4-lutidine
Purity: >97.0%
Packaging: 1g
Price: $349
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55801
Product name: 3-Bromo-2,4-dimethylpyridine
Packaging: 50mg
Price: $100
Updated: 2021/12/16

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3-BROMO-2,4-DIMETHYLPYRIDINE Chemical Properties,Usage,Production

Application

3-Bromo-2,4-dimethylpiperidine is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Synthesis

108-47-4

27063-92-9

29976-20-3

27063-93-0

Under stirring, 2,4-dimethylpyridine (5.39 mL, 46.7 mmol, 1 equiv.) was dissolved in bromide (50 mL) containing 20% free SO3, keeping the reaction temperature at 0 °C. An efficient reflux condenser was installed and the reaction mixture was heated to 165 °C in an oil bath. Bromine (4.30 mL, 83.4 mmol, 0.9 eq.) was added slowly in 0.5 mL portions over a period of 5 hours and stirring was continued at 155-175 °C for 20 hours. After completion of the reaction, the solution was cooled to room temperature, poured onto crushed ice (200 g) and stirred for 1 hour. The resulting orange solution was neutralized by careful addition of solid Na2CO3, diluted with water and extracted with EtOAc (2 x 250 mL). The organic layers were combined, dried with Na2SO4 and concentrated in vacuum. The crude product was purified by automated fast column chromatography (Biotage KP-Sil.TM.SNAP 340g column, 0-15% EtOAc/hexane) and dried under vacuum to give three bromo products: 3,5-dibromo-2,4-dimethylpyridine (8), 5-bromo-2,4-dimethylpyridine (9) and 3-bromo-2,4-dimethylpyridine (10). 3,5-Dibromo-2,4-dimethylpyridine (8) is a white solid (1.48 g, 12%) with a melting point of 28-30 °C; 1H NMR (400 MHz, CDCl3) δ 2.54 (s, 3H, CH3), 2.61 (s, 3H, CH3), 8.41 (s, 1H, pyHortho); 13C NMR (100 MHz, CDCl3) δ 23.8 (CH3), 25.7 (CH3), 120.3 (ArC), 124.4 (ArC), 146.4 (ArC), 148.5 (ArCH), 156.5 (ArC); IR νmax (film)/cm?1 3045, 2998, 2956, 2921, 1558, 1433, 1376, 1349, 1232, 1376, 1349, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232 1376, 1349, 1232, 1049, 993, 928, 783; HRMS (ESI+) m/z calcd for C7H8Br2N [M+H]+ 263.9018, found 263.9027. 5-Bromo-2,4-dimethylpyridine (9) was a colorless oil (1.89 g, 22%); 1H NMR (400 MHz, CDCl3) δ 2.32 (s, 3H, CH3), 2.44 (s, 3H, CH3), 7.00 (s, 1H, pyHortho), 8.47 (s, 1H, pyHmeta); 13C NMR ( 100 MHz, CDCl3) δ 22.1 (CH3), 23.6 (CH3), 120.4 (ArC), 125.5 (ArCH), 146.7 (ArC), 150.5 (ArCH), 157.0 (ArC); IR νmax (film)/cm?1 2985, 2957, 2924, 2854, 1592, 1461, 1377 1592, 1461, 1377, 1353, 1289, 1177, 1032; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9918. 3-Bromo-2,4-dimethylpyridine (10) was a colorless oil (3.04 g, 35%); 1H NMR (400 MHz, CDCl3) δ 2.33 (s, 3H, CH3), 2.61 (s, 3H, CH3), 6.91 (d, J = 5.0 Hz, 1H, pyHmeta), 8.18 (d, J = 5.0 Hz, 1H, 2995, 2958, 2922, 1585, 1437, 1389, 1123, 1024, 916, 825; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9917.

References

[1] Zeitschrift fuer Chemie (Stuttgart, Germany), 1988, vol. 28, # 2, p. 59 - 60
[2] Zeitschrift fuer Chemie (Stuttgart, Germany), 1988, vol. 28, # 2, p. 59 - 60
[3] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 48; 87-88
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 1, p. 127 - 135

3-BROMO-2,4-DIMETHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-BROMO-2,4-DIMETHYLPYRIDINE manufacturers

Career Henan Chemical Co

Product: 3-BROMO-2,4-DIMETHYLPYRIDINE 27063-93-0
Price: US $6.00/KG
Min. Order: 2KG
Purity: 98%
Supply Ability: 1KG,50KG,100KG
Release date: 2019-09-03

27063-93-0, 3-BROMO-2,4-DIMETHYLPYRIDINERelated Search:

3-Bromo-2,4,6-trimethylpyridine 3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE 5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE 2,4-Dimethylpiperidine 2,4-Lutidine 2-Amino-3,5-dibromo-4,6-dimethylpyridine 2-Amino-3-nitro-4,6-dimethyl-5-bromopyridine 5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile 2-AMINO-5-BROMO-4 6-DIMETHYLPYRIDINE& 5-BROMO-4,6-DIMETHYLNICOTINIC ACID 5-BROMO-4,6-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-3-AMINE 5-BROMO-4,6-DIMETHYL-2-(2-PYRIMIDINYLSULFANYL)NICOTINONITRILE OTAVA-BB BB7110952627 1-(3-BROMO-2-METHYLPYRIDIN-4-YL)ETHANONE IFLAB-BB F1957-0014 IFLAB-BB F1957-0019 5-BROMO-2-METHOXY-4,6-DIMETHYLNICOTINONITRILE SPECS AO-801/41077573

PYRIDINE, 3-BROMO-2,4-DIMETHYL

3-Bromo-2,4-Dimethylpiperidine

3-BroMo-2,4-lutidine

3-BROMO-2,4-DIMETHYLPYRIDINE

27063-93-0