Chemical Characteristics Usage Toxicology Warnings and Precautions Hazards & Safety Information
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Phosphorus oxychloride

Chemical Characteristics Usage Toxicology Warnings and Precautions Hazards & Safety Information
Product Name
Phosphorus oxychloride
CAS No.
10025-87-3
Chemical Name
Phosphorus oxychloride
Synonyms
OPCl3;POCl3;oxychloride;Fosforoxychlorid;Phosphorus oxychL;Phosphorylchlorid;fosforoxychloride;PHOSPHOROXYCHLORIDE;PHOSPHORYL CHLORIDE;Phosphoroxidchlorid
CBNumber
CB5218244
Molecular Formula
Cl3OP
Formula Weight
153.33
MOL File
10025-87-3.mol
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Phosphorus oxychloride Property

Melting point:
1.25 °C(lit.)
Boiling point:
107 °C
Density 
1.645 g/mL at 25 °C(lit.)
vapor density 
5.3 (vs air)
vapor pressure 
104 mm Hg ( 50 °C)
refractive index 
n20/D 1.461
Flash point:
105.8°C
storage temp. 
Store below +30°C.
solubility 
Phosphorus(V) oxychloride is soluble in many organic solvents.
form 
Liquid
Specific Gravity
1.692 (15/15℃)
color 
Colorless
Odor
Pungent odour
PH
1.0 (5g/l, H2O, 25℃)
Water Solubility 
reacts exothermically
Sensitive 
Moisture Sensitive
Merck 
14,7349
Exposure limits
TLV-TWA0.628 mg/m3 (0.1 ppm)(ACGIH).
Stability:
Stable. Reacts violently with water. Incompatible with many metals, alcohols, amines, phenol, DMSO, strong bases.
InChIKey
XHXFXVLFKHQFAL-UHFFFAOYSA-N
CAS DataBase Reference
10025-87-3(CAS DataBase Reference)
NIST Chemistry Reference
Phosphoryl chloride(10025-87-3)
EPA Substance Registry System
Phosphorus oxychloride (10025-87-3)
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Safety

Hazard Codes 
T+,C
Risk Statements 
14-22-26-29-35-48/23-25
Safety Statements 
26-45-7/8-36/37/39
RIDADR 
UN 1810 8/PG 2
WGK Germany 
1
RTECS 
TH4897000
19-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
28121020
Hazardous Substances Data
10025-87-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P320Specific treatment is urgent (see … on this label).

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
201170
Product name
Phosphorus(V) oxychloride
Purity
99%
Packaging
5g
Price
$37.9
Updated
2021/03/22
Sigma-Aldrich
Product number
201170
Product name
Phosphorus(V) oxychloride
Purity
99%
Packaging
1kg
Price
$101
Updated
2019/12/02
Alfa Aesar
Product number
010525
Product name
Phosphorus(V) oxychloride, 99%
Packaging
1kg
Price
$103
Updated
2021/03/22
Alfa Aesar
Product number
010525
Product name
Phosphorus(V) oxychloride, 99%
Packaging
250g
Price
$40.3
Updated
2021/03/22
Strem Chemicals
Product number
93-1543
Product name
Phosphorus oxychloride, 98+%
Packaging
1kg
Price
$166
Updated
2021/03/22
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Phosphorus oxychloride Chemical Properties,Usage,Production

Chemical Characteristics

Phosphorus oxychloride (chemical formula: POCl3), is a type of industrial raw material. It is a colorless and transparent liquid, and it has an unpleasant irritating odor. It will smoke intensely in humid air. Its relative density is 1.68, melting point is 1.25℃, boiling point is 105.1℃. It breaks down into phosphoric acid and hydrogen chloride in water and ethanol. When suddenly combined with a large amount of water, an intense reaction may occur. POCl3 reacts with water and alcohol to create phosphoric acid or phosphate. If alcohol replaces the water in the reaction, the end product will be trialkyl phosphate. This type of reaction often occurs in pyridine or ammonia, as it absorbs the produced HCl to stimulate the reaction. When catalyzed by a Lewis acid such as manganese chloride, POCl3 and a large amount of phenol (ArOH) heats to produce triaryl phosphate, such as in the reaction below: 3 C6H5OH + O=PCl3 → O=P(OC6H5)3 + 3 HCl. Phosphorus oxychloride is a Lewis base, and it produces compounds with many Lewis acids, such as in its reaction with titanium tetrachloride: Cl3P5+O− + TiCl4 → Cl3P5+O-−TiCl4. Its adduct with aluminum chloride (POCl3•AlCl3) is very stable, and thus POCl3 is used to remove the AlCl3 in the end products of Friedel-Crafts reactions. In the presence of AlCl3, POCl3 reacts with hydrogen bromide to create POBr3.

Usage

Phosphorus oxychloride can be used as a semiconductor dopant, and it is a raw material for light-conducting fibers. It is widely used in pesticides, pharmaceuticals, dyes, phosphates and flame retardant production. It is a raw material for producing organic phosphorus herbicide and chlordimeform, and it is a plasticizer in plastic production. Phosphorus oxychloride is also used in the chlorination of long-acting sulfa drugs, is an intermediate in dye production and a catalyst in organic synthesis of chlorinating agents, and it is an extracting agent in uranium mining. It is also used in producing pharmaceuticals.

Toxicology

Toxicity is similar to phosphorus trichloride, phosphorus pentachloride and phosgene. Large mice, oral, LD50: 380 mg/kg; inhaled, LC50: 32 ppm/4H. Acute poisoning in small mice results in restlessness, upper respiratory tract and conjunctival irritation, depression, convulsions, unsteady walking, lying on the side, and eventually, death. For large mice, in addition to the symptoms above, also exhibited tearing, cornea clouding, and pulmonary edema. Subacute and chronic toxicity: large mice, inhaled for 60 days at a concentration of 33.5mg/m3, exhibited slowed weight gain, skin ulcers, decreases survival rates in lung macrophages, no liver and kidney functions, and organ characteristic changes.
This product has a strong oxidizing and liposoluble effects; besides burning the digestive tract, it can also cause acute necrosis and autolysis in the liver when absorbed through the digestive tracts. Additionally, besides burning the skin, when completely absorbed through the skin, 3% can cause death in animals. When phosphorus oxychloride is inhaled and comes in contact with the moist respiratory tract mucosa, it will break down into phosphoric acid and hydrogen chloride, and it will irritate and corrode the mucosa. When humans contact at a concentration of 70mg/m3, they will usually exhibit symptoms after a 2-6h latency period, including respiratory tract mucosa irritation and eye pain. Serious cases include a choking sensation, cyanosis, pulmonary edema, heart failure, anemia, liver damage, and proteinuria. When the temperature in the car is high and the humidity is relatively low, there is a high risk of inhalation and poisoning.
The highest permitted concentration is 0.05 mg/m3. Handlers should wear protective equipment, and production equipment must be tightly sealed. Processors can also wear filtering gas masks. Take care to protect skin and eyes.
After inhalation, emergency response and treatment is similar to chlorine, hydrogen chloride and other irritating gases. If contacted with skin, first use paper or cotton to absorb the liquid, then rinse with water for at least 15 minutes; if directly rinsed with water, it may produce phosphoric acid and continue to burn the skin. Treat injury as an acid burn.
Danger regulations GB8.1 type 81040. Iron regulation: Level one inorganic acidic corrosive product, 91022. UN No. 1810. IMDG CODE page 8197, type 8.

Warnings and Precautions

Phosphorus oxychloride is often used in industrial production; there are many details to take note of when using phosphorus oxychloride to prevent safety concerns and accidents:
1. Phosphorus oxychloride preparation: As many factories use water jet vacuums to store phosphorus oxychloride, great attention must be paid to the switch order to prevent accidents. The buffer vacuum tank must be frequently inspected to prevent the water from being sucked into storage containers and causing accidents.
2. Phosphorus oxychloride with hydrogen chloride: take care to not add an excess of phosphorus chloride. If there is an excess, slowly drop in water to hydrolyze the phosphorus chloride, and then remove the produced phosphoric acid.
3. Slowly place any materials containing phosphorus oxychloride into a hydrolysis kettle containing cold water and mix continuously. Avoid adding water to the material.
4. Whenever using systems containing phosphorus oxychloride, take care to measure the water content in all the components to prevent an excess of water from causing an explosion.
5. Frequently inspect reactors for cracks and imperfections to prevent water from leaking in and coming in contact with the phosphorus oxychloride.
6. When adding phosphorus oxychloride to a reactor, remain observant and stop adding material immediately if there are any abnormal occurrences. Only continue adding material after investigating the cause of these occurrences.
7. Phosphorus oxychloride reacts slowly with water when at a lower temperature. Thus, drop in slowly to prevent sudden intense reactions.
8. Phosphorus oxychloride can be used in combination with dichloroethane and toluene solutions, but not with alcohol and ammonia solutions.

Hazards & Safety Information

Category Corrosive items
Toxicity grading highly toxic
Acute Toxicity Oral-Rat LD50: 380 mg/kg
Flammability and Hazardous characteristics being explosive upon coming across water with release of toxic chloride, phosphorus oxide gas
Storage and transportation characteristics Ventilated, low temperature and dry; and store it separately from alkali
Fire Extinguishing agent dry sand, dry stone powder; prohibit the usage of water
Occupational Standard TLV-TWA 0.1 PPM (0.6 mg/m3); STEL 0.5 PPM (3 mg/m3)

Chemical Properties

Phosphorus oxychloride is a clear, colorless to yellow, fuming, oily liquid with a pungent and musty odor.

Physical properties

Colorless fuming liquid with a pungent odor; density 1.645 g/mL; freezes at 1°C; boils at 105.5°C; reacts with water and ethanol.

Uses

In the manufacture of pesticides, pharmaceuticals, plasticizers, gasoline additives, and hydraulic fluid.

Uses

Phosphorus oxychloride is used to produce hydraulic fluids, plasticizers, and fireretarding agents; as a chlorinating agent; and as a solvent in cryoscopy.

Uses

Phosphorus oxychloride is an important intermediate in the production of triarylphosphate esters (e.g., triphenyl phosphate and tricresyl phosphate), which have been used as flame retardants and plasticizers for PVC. It is acutely toxic to the eyes, throat, and respiratory tract. Phosphorus oxychloride is also used in nuclear reprocessing, as chlorinating agent, especially to replace oxygen in organic compounds, as solvent in cryoscopy and the semiconductor industry.

Definition

A white crystalline solid. It is a monobasic acid forming the anion H2PO2 – in water. The sodium salt, and hence the acid, can be prepared by heating yellow phosphorus with sodium hydroxide solution. The free acid and its salts are powerful reducing agents.

Preparation

Phosphorus oxychloride can be prepared from phosphorus trichloride or phosphorus pentachloride. It can be obtained from phosphorus trichloride by cautious addition of potassium chlorate:
3PCl3 + KClO3 → 3POCl3 + KCl
The oxychloride also is obtained by the action of boric acid or oxalic acid with phosphorus pentachloride:
3PCl5 + 2B(OH)3 → 3POCl3 + B2O3 + 6HCl
PCl5 + (COOH)2 → POCl3 + CO + CO2 + 2HCl
Phosphorus oxychloride also is made by heating calcium phosphate in a current of chlorine and carbon monoxide at 350°C:
2Ca3(PO42 + 9Cl2 + 6CO → 4POCl3 + 6CaCO3
Alternatively, heating a mixture of calcium phosphate and carbon in a current of chlorine at 750°C yields the oxychloride.

General Description

A colorless fuming liquid with a pungent odor. Density 14.0 lb / gal. Very toxic by inhalation and corrosive to metals and tissue. Used in gasoline additives and hydraulic fluids.

Reactivity Profile

Phosphorus oxychloride is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Combining the chloride with zinc dust caused immediate ignition, due to the formation of phosphine gas which ignites, [Mellor, 1940, Vol. 8, 1025]. An exotherm starting with the mixing of Phosphorus oxychloride with acetone (a ketone) lead to an explosion, may behave similarly with other ketones, [Organic Process Research and Development, Vol.4, No. 6,200, "Phosphorus oxychloride and Acetone: An Incompatibility Investigation Using ARC."]

Hazard

The compound is highly irritating to skin, eyes and mucous membranes. Inhaling its vapors can cause pulmonary edema.

Health Hazard

Inhalation of vapors of phosphorus oxychloride produced acute and chronic toxicity in test subjects. In humans, exposure to its vapors may cause headache, dizziness, weakness, nausea, vomiting, coughing, chest pain, bronchitis, and pulmonary edema. Most of these symptoms are manifested from chronic exposure to its vapors.
LC50 value, inhalation (rats): 48 ppm (301 mg/m3)/4 h
Vapors of this compound are an irritant to the eyes and mucous membranes. The liquidis corrosive and can cause skin burns. An oral LD50 value for rats is documented to be 380 mg/kg (NIOSH 1986)..

Fire Hazard

Poisonous, corrosive, and irritating gases are generated when Phosphorus oxychloride is heated or is in contact with water. Phosphorus oxychloride may ignite other combustible materials (wood, paper, oil, etc.). Phosphorus oxychloride reacts violently with water. When heated to decomposition, Phosphorus oxychloride emits toxic fumes of chlorides and oxides of phosphorus; Phosphorus oxychloride will react with water or steam to produce heat and toxic and corrosive fumes. Incompatible with carbon disulfide; N,N-dimethylformamide; 2,5-dimethylpyrrole; 2,6-dimethyl- pyridine N-oxide; dimethylsulfoxide; Ferrocene-1,1-dicarboxylic acid; water; and zinc. Do not store with combustible materials, particularly fibrous organic materials, or with electrical or other equipment that can be corroded. Reacts violently with moisture.

Safety Profile

Poison by inhalation and ingestion. A corrosive eye, skin, and mucous membrane irritant. Potentially explosive reaction with water evolves hydrogen chloride and phosphine, which then ignites. Explosive reaction with 2,6dimethylpyridine N-oxide, dimethyl sulfoxide, ferrocene1 ,l'-dicarboxylic acid, pyridne N-oxide (above bO'C), sodmm + heat. Violent reaction or ignition with BI3, carbon disulfide, 2,5-dimethyl pyrrole + dimethyl formamide, organic matter, zinc powder. Reacts with water or steam to produce heat and toxic and corrosive fumes. Incompatible with carbon disulfide, N,Ndimethyl-formamide, 2,5-dunethylpyrrole, 2,6-dimethylpyridine N-oxide, dimethylsulfoxide, ferrocene1 ,I-dicarboxylic acid, water, zinc. When heated to decomposition it emits highly toxic fumes of Cland POx

Potential Exposure

Phosphorus oxychloride is used in the manufacture of pesticides, pharmaceuticals, plasticizers, gasoline additives; and hydraulic fluids.

Shipping

UN1810 Phosphorus oxychloride, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material, Hazard Zone B.

Purification Methods

Distil the liquid under reduced pressure to separate it from the bulk of the HCl and the phosphoric acid (from hydrolysis); the middle fraction is re-distilled into ampoules containing a little purified mercury. These ampoules are sealed and stored in the dark for 4-6weeks with occasional shaking to facilitate reaction of any free chloride with the mercury. The POCl3 is then again fractionally distilled and stored in sealed ampoules in the dark until required [Herber J Am Chem Soc 82 792 1960]. Lewis and Sowerby [J Chem Soc 336 1957] refluxed their distilled POCl3 with Na wire for 4hours, then removed the Na and again distilled. Use Na only with almost pure POCl3 to avoid explosions. HARMFUL VAPOURS; work in an efficient fume cupboard.

Incompatibilities

A powerful oxidizer. Violently decomposes in water, forming heat and hydrochloric and phosphoric acids. Violent reaction with alcohols, phenols, amines, reducing agents; combustible materials; carbon disulfide; dimethylformamide, and many other many materials. Rapid corrosion of metals, except nickel and lead.

Waste Disposal

Pour onto sodium bicarbonate. Spray with aqueous ammonia and add crushed ice. Neutralize and pour into drain with running water. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Phosphorus oxychloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Phosphorus oxychloride Suppliers

Tongshan hongda fine chemical plant
Tel
0516-87161699-
Email
sales@xzhdchem.com
Country
China
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Nanjing Xiezun Chemical Co., Ltd.
Tel
025-85620080-
Fax
025-85620080
Email
1919348357@qq.com;
Country
China
ProdList
25
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60
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6561
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50
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546-
Fax
025-87193546
Email
chemweiao@163.com;
Country
China
ProdList
9076
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60
Chengdu HuaNa Chemicals Co., Ltd.
Tel
13699069380
Fax
-
Email
515238037@qq.com
Country
China
ProdList
898
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55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862- ;
Fax
021-50908862
Email
siyansales@126.com;442785678@qq.com
Country
China
ProdList
9628
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58
Jinan Renyuan Chemical Co., Ltd.
Email
1840274076@qq.com
Country
CHINA
ProdList
214
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58
Dalian Idery Biotechnology Co., Ltd.
Tel
0411-62696576- ;0411-66160116-
Fax
0411-66160116
Email
dlidery@yeah.net;2721310367@qq.com
Country
China
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Kunshan zhonglaite Trading Co., Ltd
Tel
0512-55170668- ;0512-50323806-
Email
26886897@qq.com;474293744@qq.com
Country
China
ProdList
1710
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Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
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View Lastest Price from Phosphorus oxychloride manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Phosphorus oxychloride 10025-87-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-11-19
Hebei Dongdu Import and Export Co. LTD
Product
phosphoryl trichloride 10025-87-3
Price
US $25.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-11-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
Phosphorus oxychloride 10025-87-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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