2,4-Dichlorothieno[3,2-d]pyrimidine
- Product Name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- CAS No.
- 16234-14-3
- Chemical Name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- Synonyms
- DCTPY;EOS-60343;2,4-dichlorothieno;4-dichlorothieno[3;JAK1/2/3 Inhibitor 1;2,4-dichlorothieno[3,2-d]...;orothiopheno[3,2-d]pyrimidine;2,4-dichlorothieno[3,2-d]pgriMidine;2,4-Dichlorothieno[3,2-d]pyrimidine>2,4-Dichlorothiopheno[3,2-d]pyrimidine
- CBNumber
- CB41094220
- Molecular Formula
- C6H2Cl2N2S
- Formula Weight
- 205.06
- MOL File
- 16234-14-3.mol
2,4-Dichlorothieno[3,2-d]pyrimidine Property
- Melting point:
- 136.0 to 140.0 °C
- Boiling point:
- 274.8±22.0 °C(Predicted)
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- -0.72±0.40(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H2Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H
- InChIKey
- AQECFYPZMBRCIA-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2SC=CC2=N1
Safety
- Safety Statements
- 24/25
- RIDADR
- UN2811
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4864
- Product name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- D436150
- Product name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- D436150
- Product name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- Packaging
- 10g
- Price
- $1055
- Updated
- 2021/12/16
- Product number
- D14603
- Product name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- Packaging
- 25g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- FD149575
- Product name
- 2,4-Dichlorothieno[3,2-d]pyrimidine
- Packaging
- 2g
- Price
- $270
- Updated
- 2021/12/16
2,4-Dichlorothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production
Chemical Properties
2,4-Dichlorothieno[3,2-d]pyrimidine is White solid
Uses
2,4-Dichlorothieno[3,2-d]pyrimidine is used in the synthesis of PI3K inhibitor under noncryogenic conditions.
Synthesis
16233-51-5
16234-14-3
General procedure for the synthesis of 2,4-dichlorothieno[3,2-d]pyrimidine from thieno[3,2-d]pyrimidine-2,4-dione: To a suspension of thieno[3,2-d]pyrimidine-2,4-dione (5 g, 29 mmol) in POCl3 (40 mL) was added diisopropylethylamine (13 mL, 74 mmol), and the reaction mixture was heated refluxed for 2 hours. Upon completion of the reaction, the excess POCl3 and diisopropylethylamine were removed by distillation under reduced pressure. The resulting brown solid was dissolved in chloroform followed by aqueous phase partitioning. The aqueous phase was adjusted to alkaline by adding 5 M NaOH solution and extracted twice with chloroform. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous Na2SO4 and filtered, and concentrated to afford the target product 2,4-dichlorothieno[3,2-d]pyrimidine as a light brown solid (6.05 g, quantitative yield).1H NMR (CDCl3, 300 MHz): δ 8.16 (d, J = 5.4 Hz, 1H), 7.56 (d, J = 5.7 Hz, 1H); LRMS (ESI): m/z calculated values [M + H]+ 204.94, 206.94, measured values 205.1, 207.0.
References
[1] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 91
[2] Patent: WO2005/49033, 2005, A1. Location in patent: Page/Page column 108
[3] Organic Process Research and Development, 2013, vol. 17, # 1, p. 97 - 107
[4] Patent: WO2011/79231, 2011, A1. Location in patent: Page/Page column 82
[5] Patent: JP6120311, 2017, B2. Location in patent: Paragraph 0130-0131
2,4-Dichlorothieno[3,2-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichlorothieno[3,2-d]pyrimidine manufacturers
- Product
- 2,4-Dichlorothieno[3,2-d]pyrimidine 16234-14-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- DCTPY 16234-14-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- DCTPY 16234-14-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09