ChemicalBook > CAS DataBase List > 2,4-Dichlorothieno[3,2-d]pyrimidine

2,4-Dichlorothieno[3,2-d]pyrimidine

Product Name: 2,4-Dichlorothieno[3,2-d]pyrimidine
CAS No.: 16234-14-3
Chemical Name: 2,4-Dichlorothieno[3,2-d]pyrimidine
Synonyms: DCTPY;EOS-60343;2,4-dichlorothieno;4-dichlorothieno[3;JAK1/2/3 Inhibitor 1;2,4-dichlorothieno[3,2-d]...;orothiopheno[3,2-d]pyrimidine;2,4-dichlorothieno[3,2-d]pgriMidine;2,4-Dichlorothieno[3,2-d]pyrimidine>2,4-Dichlorothiopheno[3,2-d]pyrimidine
CBNumber: CB41094220
Molecular Formula: C6H2Cl2N2S
Formula Weight: 205.06
MOL File: 16234-14-3.mol

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2,4-Dichlorothieno[3,2-d]pyrimidine Property

Melting point:: 136.0 to 140.0 °C
Boiling point:: 274.8±22.0 °C(Predicted)
Density: 1.662±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -0.72±0.40(Predicted)
color: White to Almost white
InChI: InChI=1S/C6H2Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H
InChIKey: AQECFYPZMBRCIA-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C2SC=CC2=N1

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Safety

Safety Statements: 24/25
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4864
Product name: 2,4-Dichlorothieno[3,2-d]pyrimidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $49
Updated: 2025/07/31

TRC

Product number: D436150
Product name: 2,4-Dichlorothieno[3,2-d]pyrimidine
Packaging: 1g
Price: $130
Updated: 2021/12/16

TRC

Product number: D436150
Product name: 2,4-Dichlorothieno[3,2-d]pyrimidine
Packaging: 10g
Price: $1055
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: D14603
Product name: 2,4-Dichlorothieno[3,2-d]pyrimidine
Packaging: 1g
Price: $3
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: D14603
Product name: 2,4-Dichlorothieno[3,2-d]pyrimidine
Packaging: 5g
Price: $9
Updated: 2021/12/16

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2,4-Dichlorothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

2,4-Dichlorothieno[3,2-d]pyrimidine is White solid

Uses

2,4-Dichlorothieno[3,2-d]pyrimidine is used in the synthesis of PI3K inhibitor under noncryogenic conditions.

Synthesis

16233-51-5

16234-14-3

General procedure for the synthesis of 2,4-dichlorothieno[3,2-d]pyrimidine from thieno[3,2-d]pyrimidine-2,4-dione: To a suspension of thieno[3,2-d]pyrimidine-2,4-dione (5 g, 29 mmol) in POCl3 (40 mL) was added diisopropylethylamine (13 mL, 74 mmol), and the reaction mixture was heated refluxed for 2 hours. Upon completion of the reaction, the excess POCl3 and diisopropylethylamine were removed by distillation under reduced pressure. The resulting brown solid was dissolved in chloroform followed by aqueous phase partitioning. The aqueous phase was adjusted to alkaline by adding 5 M NaOH solution and extracted twice with chloroform. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous Na2SO4 and filtered, and concentrated to afford the target product 2,4-dichlorothieno[3,2-d]pyrimidine as a light brown solid (6.05 g, quantitative yield).1H NMR (CDCl3, 300 MHz): δ 8.16 (d, J = 5.4 Hz, 1H), 7.56 (d, J = 5.7 Hz, 1H); LRMS (ESI): m/z calculated values [M + H]+ 204.94, 206.94, measured values 205.1, 207.0.

References

[1] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 91
[2] Patent: WO2005/49033, 2005, A1. Location in patent: Page/Page column 108
[3] Organic Process Research and Development, 2013, vol. 17, # 1, p. 97 - 107
[4] Patent: WO2011/79231, 2011, A1. Location in patent: Page/Page column 82
[5] Patent: JP6120311, 2017, B2. Location in patent: Paragraph 0130-0131

2,4-Dichlorothieno[3,2-d]pyrimidine Preparation Products And Raw materials

Raw materials

Methyl 3-amino-2-thiophenecarboxylate Phosphorus oxitrichloride Urea

Preparation Products

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View Lastest Price from 2,4-Dichlorothieno[3,2-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-Dichlorothieno[3,2-d]pyrimidine 16234-14-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: DCTPY 16234-14-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: DCTPY 16234-14-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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2,4-Dichlorothieno[3,2-d]pyrimidine≥ 98%(GC)

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2,4-Dichlorothieno[3,2-d]pyrimidine&gt

orothiopheno[3,2-d]pyrimidine

2,4-Dichlorothieno[3,2-d]pyrimidine ISO 9001：2015 REACH

DCTPY

JAK1/2/3 Inhibitor 1

2, 4-dichlorothienol [3, 2-d] pyrimidine

16234-14-3

Heterocycle-Pyrimidine series

API intermediates

CHIRAL CHEMICALS

Heterocycles