2-Chloro-3',4'-dihydroxyacetophenone

Product Name: 2-Chloro-3',4'-dihydroxyacetophenone
CAS No.: 99-40-1
Chemical Name: 2-Chloro-3',4'-dihydroxyacetophenone
Synonyms: 2-Chloro-3'Chloracetylcatechol;Chloroaceto catechol;Chloroacetylcatechol;2-Chloro-3',4'-dihyd;Chloraoetyl Catechol;P-CHLOROACETYLCATECHOL;4-(CHLORACETAL)CATECHOL;4-(CHLOROACETO)CATECHOL;CHLOROACETOPYROCATECHOL
CBNumber: CB7415326
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 99-40-1.mol

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2-Chloro-3',4'-dihydroxyacetophenone Property

Melting point:: 174-176 °C(lit.)
Boiling point:: 418.7±35.0 °C(Predicted)
Density: 1.444±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO, methanol.
pka: 7.59±0.20(Predicted)
form: powder
color: White to Pale Beige
BRN: 2092660
InChI: InChI=1S/C8H7ClO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,10-11H,4H2
InChIKey: LWTJEJCZJFZKEL-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(O)C(O)=C1)CCl
CAS DataBase Reference: 99-40-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HS Code: 29252900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000682
Product name: Noradrenaline impurity E
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: C34405
Product name: 2-Chloro-3′,4′-dihydroxyacetophenone
Purity: 97%
Packaging: 25g
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000682
Product name: Noradrenaline impurity E
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000682
Price: $220
Updated: 2024/03/01

TCI Chemical

Product number: C0156
Product name: 4-(Chloroacetyl)catechol
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $65
Updated: 2025/07/31

TRC

Product number: C365325
Product name: 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone
Packaging: 100g
Price: $200
Updated: 2021/12/16

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2-Chloro-3',4'-dihydroxyacetophenone Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

2-Chloro-3',4'-dihydroxyacetophenone is used as a styptic adrenobazone, quasi adrenaline drug gasp spirit of intermediates.

Definition

ChEBI: 2-chloro-3',4'-dihydroxyacetophenone is an alpha-chloroketone, a member of acetophenones and an aromatic ketone.

Synthesis

120-80-9

79-04-9

99-40-1

Anhydrous aluminum trichloride (6.0 g, 45 mmol) was slowly added to the cooled 1,2-dichloroethane (20 mL) solution at 5-10 °C and stirred for 30 min keeping the temperature at 5-10 °C. Subsequently, catechol (1) (2.0 g, 18.1 mmol) was added to the reaction mixture in batches over a period of 10 minutes and stirring was continued for 20 minutes. Chloroacetyl chloride (2.2 g, 19.3 mmol) was added dropwise to the reaction system at the same temperature. The reaction system was then warmed up to room temperature with continuous stirring for 20 hours. Upon completion of the reaction, the reaction was carefully quenched with dilute hydrochloric acid solution (40 mL) at 5-10 °C and stirred at room temperature for 2-3 hours. The solid product was collected by filtration and washed with water. The wet solid was suspended in dilute acetic acid and heated until completely dissolved. Activated charcoal (0.1 g) was added to the clarified solution to decolorize it, stirred for 30 minutes and then hot filtered. The filtrate was cooled to precipitate a solid, filtered, washed with water and dried to give the target product 2-chloro-1-(3,4-dihydroxyphenyl)ethanone (2). Yield: 2.5 g, 74% yield; melting point 175-177 °C.

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 82, p. 293 - 307
[2] Patent: WO2008/107109, 2008, A1. Location in patent: Page/Page column 4-5
[3] Patent: WO2018/127806, 2018, A1. Location in patent: Page/Page column 8
[4] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 858
[5] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1893, vol. 25, p. 154

2-Chloro-3',4'-dihydroxyacetophenone Preparation Products And Raw materials

Raw materials

Chloroacetic acid Phosphorus oxitrichloride Catechol

Preparation Products

Adrenalone

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2-Chloro-3',4'-dihydroxyacetophenone Suppliers

Americas 1 Canada 2 China 368 Europe 3 France 1 Germany 7 India 29 Italy 3 Japan 2 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 42 Global 478

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View Lastest Price from 2-Chloro-3',4'-dihydroxyacetophenone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Chloro-3',4'-dihydroxyacetophenone 99-40-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 2-Chloro-3',4'-dihydroxyacetophenone 99-40-1
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-3',4'-dihydroxyacetophenone 99-40-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-29

99-40-1, 2-Chloro-3',4'-dihydroxyacetophenoneRelated Search:

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2-Chloro-1-(3,4-dihydroxyphenyl)ethan-1-one, 4-(Chloroacetyl)catechol, 2-Chloro-3',4'-dihydroxyacetophenone

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2-Chloro-3',4'-dihydroxyacetophenone 99-40-1

Chloraoetyl Catechol

2-Chloro-3&#39

2-Chloro-3',4'-dihydroxyacetop(99-40-1)

Noradrenaline Tartrate Impurity E

Noradrenaline Tartrate EP Impurity E

2-Chloro-3',4'-dihydroxyacetophenone

2-Chloro-3′,4′-dihydroxyacetophenone, CAS 99-40-1

2-chloro-1-(3,4-dihydroxyphenyl)-ethanone (Chlorketone)

2-Chloro-3',4'-dihydroxyacetophenone

99-40-1

HO2C6H3COCH2Cl

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Organic Building Blocks