Identification Description Regulatory Status Usage Natural occurrence
ChemicalBook > CAS DataBase List > 4'-Methoxyacetophenone

4'-Methoxyacetophenone

Identification Description Regulatory Status Usage Natural occurrence
Product Name
4'-Methoxyacetophenone
CAS No.
100-06-1
Chemical Name
4'-Methoxyacetophenone
Synonyms
Epenone;Novatone;Vananote;VANATONE;NSC 5601;FEMA 2005;Linarodin;AKOS 90580;Acetanisol;NSC 209523
CBNumber
CB1132155
Molecular Formula
C9H10O2
Formula Weight
150.17
MOL File
100-06-1.mol
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4'-Methoxyacetophenone Property

Melting point:
36-38 °C (lit.)
Boiling point:
152-154 °C/26 mmHg (lit.)
Density 
1.08
FEMA 
2005 | ACETANISOLE
refractive index 
1.5470 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: soluble2.474g/L at 20°C
form 
Crystals or Crystalline Powder
color 
White
Water Solubility 
insoluble
Sensitive 
Light Sensitive
JECFA Number
810
BRN 
742313
InChIKey
NTPLXRHDUXRPNE-UHFFFAOYSA-N
CAS DataBase Reference
100-06-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetophenone, 4'-methoxy-(100-06-1)
EPA Substance Registry System
4'-Methoxyacetophenone (100-06-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-38-36/38-20/21/22
Safety Statements 
37-37/39-26-36
WGK Germany 
2
RTECS 
AM9240000
TSCA 
Yes
HS Code 
29145000
Hazardous Substances Data
100-06-1(Hazardous Substances Data)
Toxicity
The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%,FCC,FG
Packaging
1 SAMPLE-K
Price
$50
Updated
2021/12/16
Sigma-Aldrich
Product number
117374
Product name
4′-Methoxyacetophenone
Purity
99%
Packaging
5g
Price
$27.6
Updated
2021/12/16
Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
1 kg
Price
$120
Updated
2021/12/16
Sigma-Aldrich
Product number
117374
Product name
4′-Methoxyacetophenone
Purity
99%
Packaging
1kg
Price
$125
Updated
2021/12/16
Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
5 kg
Price
$390
Updated
2021/12/16
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4'-Methoxyacetophenone Chemical Properties,Usage,Production

Identification

CAS.No.: 
100-06-1 
FL.No.: 
7.038
FEMA.No.: 
2005
NAS.No.: 
2005
CoE.No.: 
570
EINECS.No.: 
202-815-9 
JECFA.No.: 
810
 
 

Description

Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.

Regulatory Status

CoE: Approved. Bev.: 10 ppm; Food: 20 ppm
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).

Usage

Reported uses (ppm): (FEMA, 1994)

Food Category 
Usual 
Max. 
Alcoholic.beverages 
0.0001
0.0001
Baked.goods 
1.5
2
Chewing.gum 
110
110
Frozen.dairy 
1
2
Gelatins,.puddings 
0.2
0.2
Hard.candy 
278.3
335
Meat.products 
100
100
Nonalcoholic.beverages 
7.8
150
Soft.candy 
2.1
31

Natural occurrence

Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Chemical Properties

4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel–Crafts acetylation of anisole. A modern process uses ??-zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumes

Chemical Properties

Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors

Occurrence

Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).

Uses

4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4?-methoxyacetophenone with α,ω-dienes to yield copolymers.

Uses

4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.

Uses

Perfumery (for floral odors), flavoring.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.

Preparation

From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride.

Taste threshold values

Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036
Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617
Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1

General Description

4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system.

Safety Profile

Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]

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4'-Methoxyacetophenone Suppliers

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453- ;
Fax
0536-2101172
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
801
Advantage
58
Shanghai Jiuqu Biotechnology Co., Ltd.
Tel
17821436236
Email
3203543846@qq.com
Country
CHINA
ProdList
141
Advantage
58
Nanjing Jingwei Chemical Co., Ltd.
Tel
;
Email
tulie6416@126.com;tulie6416@126.com
Country
China
ProdList
55
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
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View Lastest Price from 4'-Methoxyacetophenone manufacturers

Wuhan Mulei New Material Technology Co. Ltd
Product
4'-Methoxyacetophenone 100-06-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99.9%
Supply Ability
100000kg per month
Release date
2021-04-02
Hebei Crovell Biotech Co Ltd
Product
4'-Methoxyacetophenone 100-06-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
10000kg
Release date
2021-06-08
Hebei Yirun Sega Biological Technology Co. Ltd
Product
4'-Methoxyacetophenone 100-06-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500ton/Month
Release date
2021-03-17

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