4'-Methoxyacetophenone
Identification Description Regulatory Status Usage Natural occurrence- Product Name
- 4'-Methoxyacetophenone
- CAS No.
- 100-06-1
- Chemical Name
- 4'-Methoxyacetophenone
- Synonyms
- 4-METHOXYACETOPHENONE;ACETANISOLE;1-(4-METHOXYPHENYL)ETHANONE;4-ACETYLANISOLE;P-ACETYLANISOLE;Acetanisol;P-METHOXYACETOPHENONE;Ethanone, 1-(4-methoxyphenyl)-;Vananote;p-Acetoanisole
- CBNumber
- CB1132155
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 100-06-1.mol
4'-Methoxyacetophenone Property
- Melting point:
- 36-38 °C (lit.)
- Boiling point:
- 152-154 °C/26 mmHg (lit.)
- Density
- 1.08
- vapor pressure
- 0.42Pa at 20℃
- refractive index
- 1.5470 (estimate)
- FEMA
- 2005 | ACETANISOLE
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- H2O: soluble2.474g/L at 20°C
- form
- Crystals or Crystalline Powder
- color
- White
- Odor
- at 100.00 %. sweet hawthorn anisic powdery balsamic acacia
- Odor Type
- anisic
- Water Solubility
- insoluble
- Sensitive
- Light Sensitive
- JECFA Number
- 810
- BRN
- 742313
- InChIKey
- NTPLXRHDUXRPNE-UHFFFAOYSA-N
- LogP
- 1.79 at 20℃
- CAS DataBase Reference
- 100-06-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetophenone, 4'-methoxy-(100-06-1)
- EPA Substance Registry System
- 4'-Methoxyacetophenone (100-06-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-38-36/38-20/21/22
- Safety Statements
- 37-37/39-26-36
- WGK Germany
- 2
- RTECS
- AM9240000
- TSCA
- Yes
- HS Code
- 29145000
- Hazardous Substances Data
- 100-06-1(Hazardous Substances Data)
- Toxicity
- The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973).
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- W200506
- Product name
- Acetanisole
- Purity
- ≥98%, FCC, FG
- Packaging
- 1kg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- W200506
- Product name
- Acetanisole
- Purity
- ≥98%, FCC, FG
- Packaging
- 5kg
- Price
- $461
- Updated
- 2024/03/01
- Product number
- 117374
- Product name
- 4′-Methoxyacetophenone
- Purity
- 99%
- Packaging
- 5g
- Price
- $36.4
- Updated
- 2024/03/01
- Product number
- 117374
- Product name
- 4′-Methoxyacetophenone
- Purity
- 99%
- Packaging
- 1kg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- W200506
- Product name
- Acetanisole
- Purity
- ≥98%, FCC, FG
- Packaging
- 25kg
- Price
- $1650
- Updated
- 2023/06/20
4'-Methoxyacetophenone Chemical Properties,Usage,Production
Identification
Description
Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.
Regulatory Status
CoE: Approved. Bev.: 10 ppm; Food: 20 ppm
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).
Usage
Reported uses (ppm): (FEMA, 1994)
Natural occurrence
Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).
Chemical Properties
WHITE CRYSTALS OR CRYSTALLINE POWDER
Chemical Properties
4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel–Crafts acetylation of anisole. A modern process uses ??-zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumes
Chemical Properties
Colorless crystals or fused crystalline/Yellowish-white crystals mass. with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors. Heavier than water, practically insoluble in water. Miscible with oils, soluble in alcohol, Relatively stable in soap and under similar, mild-alkaline conditions.
Occurrence
Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).
Uses
4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4?-methoxyacetophenone with α,ω-dienes to yield copolymers.
Uses
4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.
Uses
Perfumery (for floral odors), flavoring.
Definition
ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.
Preparation
From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride.
Taste threshold values
Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036
Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617
Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1
General Description
4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system.
Flammability and Explosibility
Not classified
Safety Profile
Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Purification Methods
Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]
4'-Methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-Methoxyacetophenone manufacturers
- Product
- 4'-Methoxyacetophenone 100-06-1
- Price
- US $500.00-300.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-23
- Product
- 4'-Methoxyacetophenone 100-06-1
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-14
- Product
- 4'-Methoxyacetophenone 100-06-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-01-14