Identification Description Regulatory Status Usage Natural occurrence
ChemicalBook > CAS DataBase List > 4'-Methoxyacetophenone

4'-Methoxyacetophenone

Identification Description Regulatory Status Usage Natural occurrence
Product Name
4'-Methoxyacetophenone
CAS No.
100-06-1
Chemical Name
4'-Methoxyacetophenone
Synonyms
4-METHOXYACETOPHENONE;ACETANISOLE;1-(4-METHOXYPHENYL)ETHANONE;4-ACETYLANISOLE;P-ACETYLANISOLE;Acetanisol;P-METHOXYACETOPHENONE;Ethanone, 1-(4-methoxyphenyl)-;Vananote;p-Acetoanisole
CBNumber
CB1132155
Molecular Formula
C9H10O2
Formula Weight
150.17
MOL File
100-06-1.mol
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4'-Methoxyacetophenone Property

Melting point:
36-38 °C (lit.)
Boiling point:
152-154 °C/26 mmHg (lit.)
Density 
1.08
vapor pressure 
0.42Pa at 20℃
refractive index 
1.5470 (estimate)
FEMA 
2005 | ACETANISOLE
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: soluble2.474g/L at 20°C
form 
Crystals or Crystalline Powder
color 
White
Odor
at 100.00 %. sweet hawthorn anisic powdery balsamic acacia
Odor Type
anisic
Water Solubility 
insoluble
Sensitive 
Light Sensitive
JECFA Number
810
BRN 
742313
InChIKey
NTPLXRHDUXRPNE-UHFFFAOYSA-N
LogP
1.79 at 20℃
CAS DataBase Reference
100-06-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetophenone, 4'-methoxy-(100-06-1)
EPA Substance Registry System
4'-Methoxyacetophenone (100-06-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-38-36/38-20/21/22
Safety Statements 
37-37/39-26-36
WGK Germany 
2
RTECS 
AM9240000
TSCA 
Yes
HS Code 
29145000
Hazardous Substances Data
100-06-1(Hazardous Substances Data)
Toxicity
The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
1kg
Price
$141
Updated
2024/03/01
Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
5kg
Price
$461
Updated
2024/03/01
Sigma-Aldrich
Product number
117374
Product name
4′-Methoxyacetophenone
Purity
99%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
117374
Product name
4′-Methoxyacetophenone
Purity
99%
Packaging
1kg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
25kg
Price
$1650
Updated
2023/06/20
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4'-Methoxyacetophenone Chemical Properties,Usage,Production

Identification

CAS.No.: 
100-06-1 
FL.No.: 
7.038
FEMA.No.: 
2005
NAS.No.: 
2005
CoE.No.: 
570
EINECS.No.: 
202-815-9 
JECFA.No.: 
810
　
　

Description

Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.

Regulatory Status

CoE: Approved. Bev.: 10 ppm; Food: 20 ppm
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).

Usage

Reported uses (ppm): (FEMA, 1994)

Food Category 
Usual 
Max. 
Alcoholic.beverages 
0.0001
0.0001
Baked.goods 
1.5
2
Chewing.gum 
110
110
Frozen.dairy 
1
2
Gelatins,.puddings 
0.2
0.2
Hard.candy 
278.3
335
Meat.products 
100
100
Nonalcoholic.beverages 
7.8
150
Soft.candy 
2.1
31

Natural occurrence

Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Chemical Properties

4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel–Crafts acetylation of anisole. A modern process uses ??-zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumes

Chemical Properties

Colorless crystals or fused crystalline/Yellowish-white crystals mass. with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors. Heavier than water, practically insoluble in water. Miscible with oils, soluble in alcohol, Relatively stable in soap and under similar, mild-alkaline conditions.

Occurrence

Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).

Uses

4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4?-methoxyacetophenone with α,ω-dienes to yield copolymers.

Uses

4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.

Uses

Perfumery (for floral odors), flavoring.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.

Preparation

From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride.

Taste threshold values

Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036
Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617
Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1

General Description

4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system.

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]

4'-Methoxyacetophenone Preparation Products And Raw materials

Raw materials

Bentonite,calcium base Acetyl chloride Anisole Ferric chloride Aluminum chloride Aluminium chloride hexahydrate

Preparation Products

4-(1,2,3-THIADIAZOL-4-YL)PHENOL 3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxamide ,97% 5-AMINO-3-(4-METHOXYPHENYL)ISOXAZOLE 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOHYDRAZIDE 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOLE 2-Bromo-4'-methoxyacetophenone 5-(4-METHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 5-(4-METHOXY-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE 4-Methoxyphenylacetic acid ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID CHLOROTRIANISENE
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4'-Methoxyacetophenone Suppliers

Americas 1 Australia 1 Belgium 4 Canada 3 China 493 Europe 4 France 2 Germany 10 India 77 Italy 1 Japan 8 Poland 1 Singapore 1 Slovakia 1 South Korea 2 Spain 2 Switzerland 4 Ukraine 1 United Kingdom 14 United States 66 USA 1 Global 697
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View Lastest Price from 4'-Methoxyacetophenone manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4'-Methoxyacetophenone 100-06-1
Price
US $500.00-300.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-23
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4'-Methoxyacetophenone 100-06-1
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4'-Methoxyacetophenone 100-06-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-01-14

100-06-1, 4'-MethoxyacetophenoneRelated Search:

3,4-Dimethoxyacetophenone Chalcone Acetophenone 4'-Hydroxyacetophenone 4'-Bromoacetophenone 2-Bromoacetophenone 2-Fluoro-4-methoxyacetophenone 4-Methoxyphenethylamine 3-Nitroacetophenone 4-Methoxyphenylacetic acid 4'-Methylacetophenone 4-Nitroacetophenone 4-Methoxybenzyl cyanide 4-Methoxystyrene 4-Methylbenzyl cyanide 4'-Methylpropiophenone Methoxypropiophenone p-Anisaldehyde Para Methoxy Acetophenone

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