4'-Methylpropiophenone

Product Name: 4'-Methylpropiophenone
CAS No.: 5337-93-9
Chemical Name: 4'-Methylpropiophenone
Synonyms: 4-METHYLPROPIOPHENONE;1-(p-Tolyl)propan-1-one;ETHYL-P-TOLYLKETON;LABOTEST-BB LT00053050;4-Methylpropiophenon;P-METHYLPROPIOPHENONE;P-Methyl phenylethylketone;Ethyl 4-methylphenyl ketone;1-(4-methylphenyl)-propan-1-one;4-Methylpropiophenone wickr bettyml
CBNumber: CB8116040
Molecular Formula: C10H12O
Formula Weight: 148.2
MOL File: 5337-93-9.mol

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4'-Methylpropiophenone Property

Melting point:: 7.2 °C
Boiling point:: 238-239 °C(lit.)
Density: 0.993 g/mL at 25 °C(lit.)
refractive index: n20/D 1.528(lit.)
Flash point:: 229 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in chloroform and hexane.
form: Oil
color: Colourless
Specific Gravity: 0.99
BRN: 2042137
InChI: InChI=1S/C10H12O/c1-3-10(11)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3
InChIKey: PATYHUUYADUHQS-UHFFFAOYSA-N
SMILES: C(C1=CC=C(C)C=C1)(=O)CC
CAS DataBase Reference: 5337-93-9(CAS DataBase Reference)
NIST Chemistry Reference: 4'-Methylpropiophenone(5337-93-9)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29143990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 517925
Product name: 4′-Methylpropiophenone
Purity: 90%, technical grade
Packaging: 100ml
Price: $81.3
Updated: 2025/07/31

TCI Chemical

Product number: M0768
Product name: 4'-Methylpropiophenone
Purity: >95.0%(GC)
Packaging: 25mL
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: M0768
Product name: 4'-Methylpropiophenone
Purity: >95.0%(GC)
Packaging: 500mL
Price: $246
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK120280
Product name: 4'-Methylpropiophenone
Purity: 98%
Packaging: 500g
Price: $106
Updated: 2021/12/16

Oakwood

Product number: 216656
Product name: 1-(p-Tolyl)propan-1-one
Purity: 98%
Packaging: 25g
Price: $10
Updated: 2021/12/16

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4'-Methylpropiophenone Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid

Uses

4'-methylpropiophenone has been reported to be used in the synthesis of pharmaceutical compounds such as tolperisone and other muscle relaxants. The substance is also a starting material in the synthesis of 4-methylmethcathinone (mephedrone). Mephedrone has been encountered as a ‘legal high’ and on the illicit drug market masquerading as cocaine (in powder form), MDMA (in tablet form) and as an adulterant. According to the 2016 European Drugs Market Report produced by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), mephedrone has created a specific demand and carved its own distinct market share.

Uses

4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.

Application

4′-Methylpropiophenone can be used as a building block to synthesize:
N-(4-Chlorophenyl)-N′-[1-(4-methylphenyl)propyl]urea as a potential CRAC channel inhibitor.
Mono and trinuclear cobaloxime/organocobaloxime complexes, which are used as efficient catalysts for the synthesis of cyclic carbonates.
Tolperisone (TOL) via acid-catalyzed reaction with piperidine hydrochloride and 1,2-dioxolane.

Definition

ChEBI: 4-methylpropiophenone is an aromatic ketone that is propiophenone bearing a methyl group at C-4. It derives from a propiophenone.

Synthesis

4'-Methylpropiophenone can be synthesized through various methods. One common approach involves the reaction of propiophenone with methylmagnesium bromide or methyl lithium in the presence of a catalyst. Another method utilizes Friedel-Crafts acylation, where propiophenone is acylated with methyl chloride or methyl bromide using a Lewis acid catalyst. These methods allow for the controlled introduction of the methyl group onto the phenyl ring.

4'-Methylpropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

Tolperisone hydrochloride

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4'-Methylpropiophenone Suppliers

Americas 1 Australia 1 Belgium 2 Canada 1 China 443 Europe 3 Germany 3 India 44 Japan 6 Poland 1 Singapore 1 Slovakia 1 South Korea 2 Switzerland 2 Ukraine 2 United Kingdom 6 United States 30 Global 549

Shanghai Bojing Chemical Co., Ltd

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 4'-Methylpropiophenone manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 4'-Methylpropiophenone 5337-93-9
Price: US $1.00/box
Min. Order: 1box
Purity: 99.2
Supply Ability: 20tons
Release date: 2025-11-04

Hebei Dangtong Import and export Co LTD

Product: 4'-Methylpropiophenone 5337-93-9
Price: US $30.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 300tons
Release date: 2025-11-03

RongNa Biotechnology Co.,Ltd

Product: 1-(4-methylphenyl)-propan-1-one 5337-93-9
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 10 ton
Release date: 2025-05-16

5337-93-9, 4'-MethylpropiophenoneRelated Search:

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4'-Methylpropiophenone Basic information

4' -Methylpropiophenone C10H12O

4'-Methylpropiophenone CAS 5337 93 9

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