Uses
ChemicalBook > CAS DataBase List > p-Toluic acid

p-Toluic acid

Uses
Product Name
p-Toluic acid
CAS No.
99-94-5
Chemical Name
p-Toluic acid
Synonyms
PTLA;p-toluic;p-Toluylsure;P-TOLUIC ACID;4-TOLUIC ACID;P-TOLUYLIC ACID;Crithminic acid;p-carboxytoluene;para-Toluic acid;P-ToluicAcid>98%
CBNumber
CB7854776
Molecular Formula
C8H8O2
Formula Weight
136.15
MOL File
99-94-5.mol
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p-Toluic acid Property

Melting point:
177-180 °C (lit.)
Boiling point:
274-275 °C (lit.)
Density 
1,06 g/cm3
vapor pressure 
0.02 hPa (70 °C)
refractive index 
1.5120 (estimate)
Flash point:
181°C
storage temp. 
Store below +30°C.
solubility 
0.3g/l
pka
4.36(at 25℃)
form 
Powder
color 
White to slightly yellow-cream
Water Solubility 
<0.1 g/100 mL at 19 ºC
Merck 
14,9535
BRN 
507600
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
LPNBBFKOUUSUDB-UHFFFAOYSA-N
CAS DataBase Reference
99-94-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-methyl-(99-94-5)
EPA Substance Registry System
Benzoic acid, 4-methyl- (99-94-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
WGK Germany 
1
RTECS 
XU1575000
Autoignition Temperature
570 °C
TSCA 
Yes
HS Code 
29163900
Toxicity
LD50 orally in Rabbit: 400 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T36803
Product name
p-Toluic acid
Purity
98%
Packaging
5g
Price
$15.7
Updated
2021/12/16
Sigma-Aldrich
Product number
41768
Product name
p-Toluic acid
Purity
analytical standard
Packaging
100mg
Price
$84.3
Updated
2021/12/16
Sigma-Aldrich
Product number
T36803
Product name
p-Toluic acid
Purity
98%
Packaging
100g
Price
$23.3
Updated
2021/03/22
Sigma-Aldrich
Product number
T36803
Product name
p-Toluic acid
Purity
98%
Packaging
500g
Price
$59.9
Updated
2021/03/22
Sigma-Aldrich
Product number
8.21903
Product name
4-Methylbenzoic acid for synthesis. CAS 99-94-5, chemical formula 4-(CH )C H COOH., for synthesis
Packaging
8219030250
Price
$33
Updated
2020/08/18
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p-Toluic acid Chemical Properties,Usage,Production

Uses

p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.

Chemical Properties

colourless crystals or white crystalline powder. Slightly soluble in water; soluble in alcohol and ether. Combustible.

Uses

Intermediates of Liquid Crystals

Uses

p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.

Definition

ChEBI: A methylbenzoic acid in which the methyl substituent is located at position 4.

Synthesis Reference(s)

Journal of the American Chemical Society, 94, p. 4024, 1972 DOI: 10.1021/ja00766a069
The Journal of Organic Chemistry, 37, p. 2564, 1972 DOI: 10.1021/jo00981a010

Air & Water Reactions

Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.

Reactivity Profile

p-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in p-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. p-Toluic acid is incompatible with strong oxidizers. p-Toluic acid is also incompatible with strong bases. .

Fire Hazard

Flash point data for p-Toluic acid are not available; however, p-Toluic acid is probably combustible.

Purification Methods

Crystallise the acid from water, water/EtOH (1:1), MeOH/water or *benzene. [Beilstein 9 IV 1724.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008]. The S-benzylisothiuronium salt has m 164o (from aqueous EtOH).

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p-Toluic acid Suppliers

Taizhou Chemedir Biopharm-tech. Co., Ltd
Tel
0523-86200218
Fax
+86 523-86200613
Email
sale1_cmd@chemedir.com
Country
China
ProdList
110
Advantage
64
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453- ;
Fax
0536-2101172
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
801
Advantage
58
Shanghai XiZhi Chemical Co., Ltd.
Tel
021-69005855
Fax
021-69005955
Email
xizhichem@163.com
Country
China
ProdList
3344
Advantage
55
Chongqing Yuanyuanxiang Technology Development Co. LTD
Tel
023-55703781
Fax
023-55703781
Email
2022434087@qq.com
Country
China
ProdList
4280
Advantage
58
Hubei yongkuo Technology Co., Ltd
Tel
027-59223108- ;027-59223108
Fax
027-59223108
Email
1248580099@qq.com;1248580055@qq.com
Country
China
ProdList
9060
Advantage
58
Weifang Siyuan Chemical Co., Ltd.
Tel
0536-8888106
Fax
0536-8888106
Email
2354379876@qq.com
Country
China
ProdList
233
Advantage
58
Hebei mo Jin biotechnology co., ltd
Tel
Email
angelia@hbmojin.com
Country
China
ProdList
1644
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
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View Lastest Price from p-Toluic acid manufacturers

Asia Chem I and E (Jiangsu) Co Ltd
Product
4-Methylbenzoic acid 99-94-5
Price
US $4.24/Kg/Drum
Min. Order
5Kg/Drum
Purity
99.0%min
Supply Ability
60tons/month
Release date
2021-12-21
Wuhan Dujiang Industrial Co., Ltd.
Product
p-Toluic acid 99-94-5
Price
US $68.00/KG
Min. Order
1KG
Purity
Above97%
Supply Ability
Weekly supply of 1000KG
Release date
2021-11-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
p-Toluic acid 99-94-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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