4-(Chloromethyl)benzoic acid
- Product Name
- 4-(Chloromethyl)benzoic acid
- CAS No.
- 1642-81-5
- Chemical Name
- 4-(Chloromethyl)benzoic acid
- Synonyms
- P-(CHLOROMETHYL)BENZOIC ACID;AKOS BBS-00004025;RARECHEM AL BO 0358;-Chloro-p-toluicacid;à-chloro-p-toluic acid;4-Chloro-p-toluic acid;Tranexamic Impurity 16;P-(Chloromethyl)benzoic;p-Carboxbenzyl chloride;α-Chloro-p-toluylic acid
- CBNumber
- CB5739282
- Molecular Formula
- C8H7ClO2
- Formula Weight
- 170.59
- MOL File
- 1642-81-5.mol
4-(Chloromethyl)benzoic acid Property
- Melting point:
- 201-202 °C(lit.)
- Boiling point:
- 201-203 °C
- Density
- 1.315±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.11±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to slightly yellow
- Sensitive
- Moisture Sensitive
- BRN
- 1907970
- InChI
- InChI=1S/C8H7ClO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H,10,11)
- InChIKey
- OITNBJHJJGMFBN-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(CCl)C=C1
- CAS DataBase Reference
- 1642-81-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-(Chloromethyl)benzoic acid(1642-81-5)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-42/43-36
- Safety Statements
- 26-36/37/39-45-22-27-37/37/39
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 19
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29163990
- Storage Class
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Eye Dam. 1
Resp. Sens. 1
Skin Corr. 1B
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 270792
- Product name
- 4-(Chloromethyl)benzoic acid
- Purity
- 95%
- Packaging
- 10g
- Price
- $64.9
- Updated
- 2025/07/31
- Product number
- 270792
- Product name
- 4-(Chloromethyl)benzoic acid
- Purity
- 95%
- Packaging
- 50g
- Price
- $295
- Updated
- 2025/07/31
- Product number
- C1212
- Product name
- 4-(Chloromethyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $60
- Updated
- 2025/07/31
- Product number
- C369103
- Product name
- 4-(Chloromethyl)benzoic acid
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J91645
- Product name
- 4-(Chloromethyl)benzoic acid
- Packaging
- 4x25g
- Price
- $49
- Updated
- 2021/12/16
4-(Chloromethyl)benzoic acid Chemical Properties,Usage,Production
Chemical Properties
White to slightly yellow crystalline powder
Uses
4-(Chloromethyl)benzoic acid was used for the synthesis of dihydroxy stilbene derivatives.
Uses
4-(Chloromethyl)benzoic acid was used in the synthesis of dihydroxy stilbene derivatives.
Synthesis
258278-55-6
1642-81-5
Example 1: Synthesis of 4-nitro-oxo-methyl-benzoic acid (I) a) Nitration of 4-chloromethyl-benzoic acid (III) 49.29 kg of 4-chloromethyl-benzoic acid (III) was dissolved in 92.9 L of acetonitrile and stirred for 20 minutes while a slow stream of nitrogen was passed. Subsequently, 93 mL of sulfuric acid was added and stirring was continued for 15 minutes. Under the same operating conditions, 13.65 kg of silver nitrate was slowly added. The reactor was protected from light and the reaction mixture was stirred for 15 minutes. After that, the mixture was heated to reflux for 7 hours and 15 minutes. After completion of the reaction, it was cooled to 20°C-25°C. b) Post-treatment 37.2 L of dimethylformamide (DMF) was added and stirred for 30 min, maintaining the temperature between 20°C-25°C. The silver salt was separated by filtration under nitrogen pressure through a filter pre-washed with 11 L of water and containing 9 kg of filter media. The filter cake was washed with 28 L DMF in three passes. The solid waste was washed twice with 9.3 L DMF. The cellulose in the filter was removed and washed with DMF until clarified, then rinsed with water. c) Precipitation and purification The liquid phase was combined and stabilized at a temperature between 20°C and 25°C. Slowly add 1486 L of water over a period of 1 hour, maintaining the temperature between 20°C-25°C. Continue stirring for 1 hour, maintaining the same temperature range. The precipitate was separated by filtration and the filter cake was washed with water until the pH of the eluate was similar to that of water. Finally, the filter cake was washed with 18.6 L of ethanol. The wet solid was dried under vacuum at not more than 40 °C until the moisture content (KF method) was ≤ 0.2%. 9.68 kg of 4-nitro-oxo-methyl-benzoic acid (I) was obtained in 90.2% yield, 99.35% HPLC purity, and 0.23% (IV).
References
[1] Patent: WO2011/58162, 2011, A1. Location in patent: Page/Page column 7-8
4-(Chloromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Chloromethyl)benzoic acid manufacturers
- Product
- 4-(Chloromethyl)benzoic acid 1642-81-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
- Product
- 4- (Chloromethyl) Benzoic Acid 1642-81-5
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-27
- Product
- 4-(Chloromethyl)benzoic acid 1642-81-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10