Chemical Properties Uses
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3-Chloroperoxybenzoic acid

Chemical Properties Uses
Product Name
3-Chloroperoxybenzoic acid
CAS No.
937-14-4
Chemical Name
3-Chloroperoxybenzoic acid
Synonyms
M-CPBA;M-CHLOROPERBENZOIC ACID;3-CHLOROPERBENZOIC ACID;M-CHLOROPEROXYBENZOIC ACID;3-chlorobenzoperoxoic acid;3-Chlorobenzenecarboperoxoic acid;3-Chloroperoxybenzoic Acid (MCPBA);3-ChL;M-Chloroperoxybenzoic;65.0%(T)
CBNumber
CB4259408
Molecular Formula
C7H5ClO3
Formula Weight
172.57
MOL File
937-14-4.mol
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3-Chloroperoxybenzoic acid Property

Melting point:
69-71 °C(lit.)
Boiling point:
244.67°C (rough estimate)
Density 
0.56
vapor pressure 
0.373Pa at 25℃
refractive index 
1.4580 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
7.57 (in water @ 25 °C)
form 
Moist Powder
color 
White
PH
4.5@25 °C (saturated aq. sol)
Odor
slight pungent odor
Water Solubility 
insoluble
Decomposition 
>88 °C
BRN 
608317
Stability:
Strong oxidizing agent - contact with combustible material may cause fire. May be shock or heat sensitive. Incompatible with organic materials, strong reducing agents.
InChIKey
NHQDETIJWKXCTC-UHFFFAOYSA-N
LogP
1.03 at 25℃
CAS DataBase Reference
937-14-4(CAS DataBase Reference)
NIST Chemistry Reference
3-Chloroperbenzoic acid(937-14-4)
EPA Substance Registry System
Benzenecarboperoxoic acid, 3-chloro- (937-14-4)
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Safety

Hazard Codes 
O,Xi,C
Risk Statements 
5-8-36/37/38-43-7-34-22
Safety Statements 
17-26-36/37-45-36/37/39-3/7-14-27-7/9
RIDADR 
UN 3106 5.2
WGK Germany 
3
RTECS 
SD9470000
4.4
TSCA 
Yes
HazardClass 
5.2
PackingGroup 
II
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H242Heating may cause a fire

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P370+P378In case of fire: Use … for extinction.

P410Protect from sunlight.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
273031
Product name
3-Chloroperbenzoic acid
Purity
≤77%
Packaging
1kg
Price
$642
Updated
2024/03/01
Sigma-Aldrich
Product number
273031
Product name
3-Chloroperbenzoic acid
Purity
≤77%
Packaging
10kg
Price
$2048
Updated
2024/03/01
Alfa Aesar
Product number
L00286
Product name
3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water
Packaging
25g
Price
$34.1
Updated
2021/12/16
Alfa Aesar
Product number
L00286
Product name
3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water
Packaging
100g
Price
$95.2
Updated
2021/12/16
Sigma-Aldrich
Product number
273031
Product name
3-Chloroperbenzoic acid
Purity
≤77%
Packaging
25g
Price
$48.5
Updated
2024/03/01
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3-Chloroperoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

3-chloroperoxybenzoic acid is white powdery crystals. Melting point is 92-94°C (decomposed). It is almost insoluble in water, but soluble in ethanol, ethers, chloroform, and dichloroethane. It is thermally stable and has an annual decomposition rate of less than 1% at room temperature. The decomposition rate is accelerated in the liquid state. 3-Chloroperbenzoic acid is sensitive to heat and shock, and pure solid. 3-Chloroperbenzoic acid is flammable and potentially explosive. It contains a weak –O–O– bond and a nucleophilic OH group, that makes it versatile oxidative and easily breakable.

Uses

3-Chloroperoxybenzoic acid is commonly used in double bond epoxidation, nitridation, cyclization, Baeyer-Villiger oxidation, and N-oxidation. It can also be used as an oxidant for fine chemicals such as synthetic medicine and pesticides. It is also sometimes used as a bleaching agent [1-6].
• Used in cyclization reaction, Baeyer-Villiger reaction, N-oxidation reaction and S-oxidation reaction.
• Used as an oxidant for fine chemical products such as synthetic medicine and pesticides.
• Used as oxidant and bleach.
• As a good electrophilic reagent, it can react with many functional groups and can oxidize olefins, enol silyl ethers, furans, sulfides, selenides and amino compounds.

Chemical Properties

White moist powder

Uses

3-Chloroperoxybenzoic acid is a strong oxidizing agent used in the oxidation reactions such as aldehydes and ketones to esters (Bayer-Villiger-Oxidation), olefines to epoxides, sulfides to sulfoxides and sulfones, and amines to nitroalkanes, N-oxides.

Uses

Effective oxidant for epoxidizing di-, tri-, and tetra-substituted olefins.

Definition

ChEBI: 3-chloroperbenzoic acid is a peroxy acid and a member of monochlorobenzenes.

Reactions

3-Chloroperoxybenzoic acid (MCPBA) is one of the most popular oxidation reagent in organic synthesis, because of its outstanding performance in terms of:
reactivity, combined with reducing the number of reaction steps in classical synthetic routes,
regio- and stereoselectivity,
protection of functional groups mostly not required,
high purity and yields.
Its literature covers a huge area of different syntheses and below reaction equations just can be a brief overview of its interesting applications:

Synthesis Reference(s)

Synthetic Communications, 19, p. 1271, 1989 DOI: 10.1080/00397918908054534

General Description

3-Chloroperoxybenzoic acid is sensitive to heat. Storage of 3-Chloroperoxybenzoic acid must be done so with stringent temperature control measures. It's explosion hazard is also mitigated by mixing the peroxide in a solvent slurry.

Reactivity Profile

May explode from heat, shock, friction or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames.

Purification Methods

Recrystallise MCPBA from CH2Cl2 [Traylor & Mikztal J Am Chem Soc 109 2770 1987]. Peracid of 99+% purity can be obtained by washing commercial 85% material with phosphate buffer pH 7.5 and drying the residue under reduced pressure. Alternatively the peracid can be freed from m-chlorobenzoic acid by dissolving 50g/L of *benzene and washing with an aqueous solution buffered at pH 7.4 (NaH2PO4/NaOH) (5 x 100mL). The organic layer is dried over MgSO4 and carefully evaporated under vacuum. Necessary care should be taken in case of EXPLOSION. The solid is recrystallised twice from CH2Cl2/Et2O and stored at 0o in a plastic container as glass catalyses the decomposition of the peracid. The acid is assayed iodometrically. [Schwartz & Blumbrgs J Org Chem 29 1976 1964, Bortolini et al. J Org Chem 52 5093 1987, McDonald et al. Org Synth Coll Vol VI 276 1988, Beilstein 9 IV 972.]

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3-Chloroperoxybenzoic acid Suppliers

Jiangxi Boye Medical Technology Co., Ltd
Tel
18971341812/18971341812 18971341812
Fax
027-81625225
Email
anikay@boyechemicals.com
Country
China
ProdList
641
Advantage
58
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862,442785678,326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
JOYCHINE BIO-TECH
Tel
18680818008
Email
18680818008@163.com
Country
China
ProdList
35
Advantage
58
Xi'an Synthetize Industrial Co., Ltd.
Tel
15934815775
Email
lintengfei@xa-sks.com
Country
China
ProdList
34
Advantage
58
Huaian Jiamu Biotechnology Co., Ltd.
Tel
0517-83187139 18205232085
Email
cai@jiamu-bio.com
Country
China
ProdList
983
Advantage
58
Yangzhou juhechang Technology Co., Ltd
Tel
0514-0514-83662002 13073488988
Fax
0514-83662002
Email
13073488988@163.com
Country
China
ProdList
37
Advantage
58
Tianjinshi Haydn Science &Technology Development Co.,Ltd
Tel
022-88294560 13642153692
Email
313878807@qq.com
Country
China
ProdList
21
Advantage
58
Shenyang Kelaishen Chemical Products Co., Ltd.
Tel
15840211838; 15840211838
Fax
18640376777
Email
15840211838@163.com
Country
China
ProdList
19
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
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View Lastest Price from 3-Chloroperoxybenzoic acid manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
3-Chloroperoxybenzoic acid 937-14-4
Price
US $60.00-600.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-06
Changzhou waston chemical technology Co.,Ltd
Product
3-Chloroperoxybenzoic acid 937-14-4
Price
US $0.00/kg
Min. Order
1kg
Purity
89%
Supply Ability
According to customer's requirements
Release date
2023-11-20
Hebei Mojin Biotechnology Co., Ltd
Product
3-Chloroperoxybenzoic acid 937-14-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-28

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