4-Bromo-7-azaindole

Uses

Product Name: 4-Bromo-7-azaindole
CAS No.: 348640-06-2
Chemical Name: 4-Bromo-7-azaindole
Synonyms: 4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;SW-65;SWF-65;CAS:348640-06-2;4-BroMo-7-Azaindol;4-Bromo-8-azaindole;4-BROMO-7-AZAINDOLE;4-broMo-1H-pyrrolo[2;4-Bromo-1H-pyrrolo-[2,3]pyridine;1H-PYRROLO[2,3-B]PYRIDINE, 4-BROMO-
CBNumber: CB4741075
Molecular Formula: C7H5BrN2
Formula Weight: 197.03
MOL File: 348640-06-2.mol

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4-Bromo-7-azaindole Property

Melting point:: 178-183 °C
Density: 1.770±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 12.95±0.40(Predicted)
form: Solid
color: Yellow to orange
InChI: InChI=1S/C7H5BrN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)
InChIKey: LEZHTYOQWQEBLH-UHFFFAOYSA-N
SMILES: C12NC=CC1=C(Br)C=CN=2

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 703451
Product name: 4-Bromo-7-azaindole
Purity: 96%
Packaging: 1g
Price: $62.7
Updated: 2025/07/31

TCI Chemical

Product number: B6078
Product name: 4-Bromo-1H-pyrrolo[2,3-b]pyridine
Packaging: 1G
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B6078
Product name: 4-Bromo-1H-pyrrolo[2,3-b]pyridine
Packaging: 5G
Price: $188
Updated: 2025/07/31

TRC

Product number: B679970
Product name: 4-Bromo-7-azaindole
Packaging: 2.5g
Price: $165
Updated: 2021/12/16

TRC

Product number: B679970
Product name: 4-Bromo-7-azaindole
Packaging: 25g
Price: $1020
Updated: 2021/12/16

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4-Bromo-7-azaindole Chemical Properties,Usage,Production

Uses

4-Bromo-7-azaindole is an important organic intermediate (building block) to synthetize substituted azaindole products.

Description

4-Bromo-7-azaindole is a small molecule pyridine compound containing a bromine functional group. This substance can be used as a basic structure for the synthesis of other complex organisms. It is also a good reagent and can react with amides, amines, amino acid esters and phenolic compounds through the formation of C-N and C-O bonds.

Chemical Properties

Pale yellow powder

Uses

4-Bromo-7-azaindole is chemical reagent used in the synthesis of tyrosine kinase inhibitors.

Synthesis

55052-24-9

348640-06-2

1H-pyrrolo[2,3-b]pyridine-7-oxide (3.0 g, 22.4 mmol) was used as starting material, which was co-dissolved with tetramethyl ammonium (4.13 g, 1.2 eq.) in N,N-dimethylformamide (DMF, 30 ml). Dimethyl sulfoxide (Ms2O, 7.8 g, 2.0 eq.) was added in batches at 0 °C. The reaction mixture was stirred at 0 °C for 1 h, then brought to room temperature and continued stirring for 4 h. The reaction was carried out at 0 °C. Upon completion of the reaction, the reaction solution was diluted with water (60 ml) and the pH was adjusted with solid sodium hydroxide (NaOH) to 7. Subsequently, more than 130 ml of water was added and the resultant suspension was kept at 5 °C for 1 h. The reaction was carried out by filtration. The precipitate was collected by filtration, washed with ice water (2 x 20 ml) and dried in a vacuum oven using phosphorus pentoxide (P2O5) as a desiccant to give finally 4-bromo-1H-pyrrolo[2,3-b]pyridine (2.47 g, 56% yield). Mass spectrum (ESI) m/z 196.9 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 10.77 (br s, 1H), 8.14 (d, J = 5.2 Hz, 1H), 7.42 (s, 1H), 7.31 (d, J = 5.1 Hz, 1H), 6.57 (s, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1208 - 1212
[2] Patent: CN101921268, 2016, B. Location in patent: Paragraph 0257; 0265-0268
[3] Patent: WO2010/30727, 2010, A1. Location in patent: Page/Page column 120
[4] Organic Letters, 2003, vol. 5, # 26, p. 5023 - 5025
[5] Patent: WO2009/140320, 2009, A1. Location in patent: Page/Page column 86

4-Bromo-7-azaindole Preparation Products And Raw materials

Raw materials

Methanesulfonic anhydride 7-Azaindole Tetrabutylammonium bromide 3-Chloroperoxybenzoic acid Trifluoromethanesulfonic acid

Preparation Products

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4-Bromo-7-azaindole Suppliers

Americas 1 Canada 1 China 335 Europe 1 Germany 1 India 15 Japan 1 Ukraine 1 United Kingdom 4 United States 24 Global 384

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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View Lastest Price from 4-Bromo-7-azaindole manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Bromo-7-azaindole 348640-06-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

R&D Scientific Inc.

Product: 4-Bromo-7-azaindole 348640-06-2
Price: US $1750.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-03-19

Career Henan Chemical Co

Product: 4-Bromo-7-azaindole 348640-06-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

348640-06-2, 4-Bromo-7-azaindoleRelated Search:

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4-Bromo-1H-pyrrolo-[2,3]pyridine

4-broMo-1H-pyrrolo[2

4-BroMo-7-Azaindol

4-BROMO-7-AZAINDOLE

4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE

1H-PYRROLO[2,3-B]PYRIDINE, 4-BROMO-

SWF-65

SW-65

4-Bromo-8-azaindole

CAS:348640-06-2

348640-06-2

34864-06-2

Azaindoles

6

CHIRAL CHEMICALS