4-Bromo-7-azaindole
Uses- Product Name
- 4-Bromo-7-azaindole
- CAS No.
- 348640-06-2
- Chemical Name
- 4-Bromo-7-azaindole
- Synonyms
- 4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;SW-65;SWF-65;CAS:348640-06-2;4-BroMo-7-Azaindol;4-Bromo-8-azaindole;4-BROMO-7-AZAINDOLE;4-broMo-1H-pyrrolo[2;4-Bromo-1H-pyrrolo-[2,3]pyridine;1H-PYRROLO[2,3-B]PYRIDINE, 4-BROMO-
- CBNumber
- CB4741075
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 348640-06-2.mol
4-Bromo-7-azaindole Property
- Melting point:
- 178-183 °C
- Density
- 1.770±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 12.95±0.40(Predicted)
- form
- Solid
- color
- Yellow to orange
- InChI
- InChI=1S/C7H5BrN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)
- InChIKey
- LEZHTYOQWQEBLH-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=C(Br)C=CN=2
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 703451
- Product name
- 4-Bromo-7-azaindole
- Purity
- 96%
- Packaging
- 1g
- Price
- $62.7
- Updated
- 2025/07/31
- Product number
- B6078
- Product name
- 4-Bromo-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 1G
- Price
- $47
- Updated
- 2025/07/31
- Product number
- B6078
- Product name
- 4-Bromo-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 5G
- Price
- $188
- Updated
- 2025/07/31
- Product number
- B679970
- Product name
- 4-Bromo-7-azaindole
- Packaging
- 2.5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- B679970
- Product name
- 4-Bromo-7-azaindole
- Packaging
- 25g
- Price
- $1020
- Updated
- 2021/12/16
4-Bromo-7-azaindole Chemical Properties,Usage,Production
Uses
4-Bromo-7-azaindole is an important organic intermediate (building block) to synthetize substituted azaindole products.
Description
4-Bromo-7-azaindole is a small molecule pyridine compound containing a bromine functional group. This substance can be used as a basic structure for the synthesis of other complex organisms. It is also a good reagent and can react with amides, amines, amino acid esters and phenolic compounds through the formation of C-N and C-O bonds.
Chemical Properties
Pale yellow powder
Uses
4-Bromo-7-azaindole is chemical reagent used in the synthesis of tyrosine kinase inhibitors.
Synthesis
55052-24-9
348640-06-2
1H-pyrrolo[2,3-b]pyridine-7-oxide (3.0 g, 22.4 mmol) was used as starting material, which was co-dissolved with tetramethyl ammonium (4.13 g, 1.2 eq.) in N,N-dimethylformamide (DMF, 30 ml). Dimethyl sulfoxide (Ms2O, 7.8 g, 2.0 eq.) was added in batches at 0 °C. The reaction mixture was stirred at 0 °C for 1 h, then brought to room temperature and continued stirring for 4 h. The reaction was carried out at 0 °C. Upon completion of the reaction, the reaction solution was diluted with water (60 ml) and the pH was adjusted with solid sodium hydroxide (NaOH) to 7. Subsequently, more than 130 ml of water was added and the resultant suspension was kept at 5 °C for 1 h. The reaction was carried out by filtration. The precipitate was collected by filtration, washed with ice water (2 x 20 ml) and dried in a vacuum oven using phosphorus pentoxide (P2O5) as a desiccant to give finally 4-bromo-1H-pyrrolo[2,3-b]pyridine (2.47 g, 56% yield). Mass spectrum (ESI) m/z 196.9 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 10.77 (br s, 1H), 8.14 (d, J = 5.2 Hz, 1H), 7.42 (s, 1H), 7.31 (d, J = 5.1 Hz, 1H), 6.57 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1208 - 1212
[2] Patent: CN101921268, 2016, B. Location in patent: Paragraph 0257; 0265-0268
[3] Patent: WO2010/30727, 2010, A1. Location in patent: Page/Page column 120
[4] Organic Letters, 2003, vol. 5, # 26, p. 5023 - 5025
[5] Patent: WO2009/140320, 2009, A1. Location in patent: Page/Page column 86
4-Bromo-7-azaindole Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-7-azaindole Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Bromo-7-azaindole manufacturers
- Product
- 4-Bromo-7-azaindole 348640-06-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- 4-Bromo-7-azaindole 348640-06-2
- Price
- US $1750.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-03-19
- Product
- 4-Bromo-7-azaindole 348640-06-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09