7-Azaindole
- Product Name
- 7-Azaindole
- CAS No.
- 271-63-6
- Chemical Name
- 7-Azaindole
- Synonyms
- 1H-PYRROLO[2,3-B]PYRIDINE;NSC 67063;NSC 77951;7-azindole;7-AZAINDOLE;7-Azaindole99%;7-Dideazapurine;7-Aza-7H-indole;7-AZAINDOLE 98%;7-Azaindole,98%
- CBNumber
- CB1664663
- Molecular Formula
- C7H6N2
- Formula Weight
- 118.14
- MOL File
- 271-63-6.mol
7-Azaindole Property
- Melting point:
- 105-107 °C (lit.)
- Boiling point:
- 270 °C (753.1004 mmHg)
- Density
- 1.1151 (rough estimate)
- refractive index
- 1.5500 (estimate)
- Flash point:
- 270°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- pka
- 7.69±0.20(Predicted)
- form
- Powder
- color
- White to off-white
- BRN
- 109667
- InChIKey
- MVXVYAKCVDQRLW-UHFFFAOYSA-N
- CAS DataBase Reference
- 271-63-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-Pyrrolo[2,3-b]pyridine(271-63-6)
- EPA Substance Registry System
- 1H-Pyrrolo[2,3-b]pyridine (271-63-6)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36-41-37/38-22
- Safety Statements
- 39-26-36/37/39
- WGK Germany
- 3
- RTECS
- UY8710000
- HazardClass
- IRRITANT
- HS Code
- 29339990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A95502
- Product name
- 7-Azaindole
- Purity
- 98%
- Packaging
- 1g
- Price
- $47.8
- Updated
- 2024/03/01
- Product number
- P1117
- Product name
- 1H-Pyrrolo[2,3-b]pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $27
- Updated
- 2024/03/01
- Product number
- P1117
- Product name
- 1H-Pyrrolo[2,3-b]pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $126
- Updated
- 2024/03/01
- Product number
- L07983
- Product name
- 7-Azaindole, 98%
- Packaging
- 1g
- Price
- $25.65
- Updated
- 2024/03/01
- Product number
- L07983
- Product name
- 7-Azaindole, 98%
- Packaging
- 5g
- Price
- $66.65
- Updated
- 2024/03/01
7-Azaindole Chemical Properties,Usage,Production
Chemical Properties
Brown-Cyrstalline Solid
Uses
7-Azaindole is imidazolinone derivatives as CGRP receptor antagonists used in the treatment.
A heterocyclic molecule that can be utilized as a pharmaceutical building block.
Starting material in a recent synthesis of azaserotonin.
Application
7-Azaindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate. It is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, p38 kinase inhibitors, thrombin inhibitors, etc.
Preparation
Synthesis of 7-azaindole: in a single-necked flask, add 2.0 g of 2-amino-3-methylpyridine and 2.5 g of N-Methylformanilide into 40 mL of dichloromethane, and add 3.15 g of PCl with stirring under an ice-water bath. After 4 hours of reaction, the reaction system was slowly poured into 40 mL of ammonia water, and the insoluble matter was removed by suction filtration. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, and evaporated to dryness to obtain 2.91 g of 7-azaindole as a pale yellow solid, with a yield of 70%.
Definition
ChEBI: 1H-pyrrolo[2,3-b]pyridine is a pyrrolopyridine.
Purification Methods
Recrystallise it repeatedly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the picrate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]
7-Azaindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Azaindole manufacturers
- Product
- 7-Azaindole 271-63-6
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 3000kg
- Release date
- 2024-05-14
- Product
- 7-Azaindole 271-63-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-12-25
- Product
- 7-Azaindole 271-63-6
- Price
- US $100.00-20700.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 2000tons
- Release date
- 2019-12-31