7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
- Product Name
- 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
- CAS No.
- 357263-41-3
- Chemical Name
- 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
- Synonyms
- CAS:357263-41-3;7-Chloro-6-azaindole;chloropyrrolocpyridin;7-Chloro-6-azaindole, 97%;7-Chloro-1H-pyrrolo[2,3-c...;7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE;1H-Pyrrolo[2,3-c]pyridine, 7-chloro-;7-Chloro-1h-pyrrolo[2,3-c]pyridine 98%;7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE, 95+%;7-Chloro-1H-pyrrolo[2,3-c]pyridine/7-Chloro-6-azaindole
- CBNumber
- CB4231749
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 357263-41-3.mol
7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE Property
- Melting point:
- 123-124 °C
- Boiling point:
- 335.8±22.0 °C(Predicted)
- Density
- 1.425±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 13.08±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41
- Safety Statements
- 26-36/37/39-39
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE001012
- Product name
- 7-Chloro-1H-pyrrolo[2,3-c]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $761
- Updated
- 2023/06/20
- Product number
- C422193
- Product name
- 7-Chloro-1H-pyrrolo[2,3-c]pyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C422193
- Product name
- 7-Chloro-1H-pyrrolo[2,3-c]pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C422193
- Product name
- 7-Chloro-1H-pyrrolo[2,3-c]pyridine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3H32-5-2T
- Product name
- 7-Chloro-6-azaindole
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE Chemical Properties,Usage,Production
Uses
7-Chloro-6-azaindole is a laboratory chemicals, used in food, drug, pesticide or biocidal product.
Synthesis
5470-18-8
1826-67-1
357263-41-3
The general procedure for the synthesis of 7-chloro-1H-pyrrolo[2,3-c]pyridine from 2-chloro-3-nitropyridine and vinylmagnesium bromide was as follows: 2-chloro-3-nitropyridine (10.0 g, 63.07 mmol) was dissolved in 500 mL of anhydrous tetrahydrofuran (THF) and magnetically stirred at -78 °C. An excess of vinylmagnesium bromide (1 M THF solution, 200 mL, 200.0 mmol) was added slowly dropwise, and after completion of the dropwise addition, the reaction mixture was slowly warmed to -20 °C and kept for 16 hours. Subsequently, saturated aqueous ammonium chloride solution (300 g/L, 150 mL, 841.25 mmol) was added dropwise under vigorous stirring to quench the reaction. The resulting suspension was filtered through Hyflo Super Cel filter aid (pre-calcined treatment) and extracted with ethyl acetate (EtOAc, 3×). The organic phases were combined and concentrated, and finally purified by automated fast column chromatography (eluent: dichloromethane/methanol, 97:3, followed by dichloromethane/methanol/ammonium hydroxide, 980:18.75:1.25) to afford the pure product, 7-chloro-1H-pyrrolo[2,3-c]pyridine (3.87 g, 38% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.73 (s, 1H), 8.04 (d, J = 5.5 Hz, 1H), 7.53-7.46 (m, 1H), 7.43 (dd, J = 6.2, 3.4 Hz, 1H), 6.64 (dd, J = 3.1, 2.1 Hz, 1H).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4009 - 4022
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 10, p. 5086 - 5098
[3] Patent: WO2010/51781, 2010, A1. Location in patent: Page/Page column 48
[4] Patent: US2011/263541, 2011, A1. Location in patent: Page/Page column 35
[5] Patent: WO2017/120429, 2017, A1. Location in patent: Page/Page column 258
7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE manufacturers
- Product
- 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE 357263-41-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-19
- Product
- 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE 357263-41-3
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04