1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-
- CAS No.
- 918515-16-9
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-
- Synonyms
- 4-Chloro-3-formyl-7-azaindole;4-Chloro-7-azaindole-3-carbaldehyde;4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde;4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde;1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-;4-Chloro-3-formyl-7-azaindole/4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
- CBNumber
- CB41872055
- Molecular Formula
- C8H5ClN2O
- Formula Weight
- 180.59
- MOL File
- 918515-16-9.mol
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- Property
- Density
- 1.521±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 11.48±0.40(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C422195
- Product name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC16335
- Product name
- 4-Chloro-3-formyl-7-azaindole
- Packaging
- 500g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- OR927654
- Product name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H56-5-D8
- Product name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FC16335
- Product name
- 4-Chloro-3-formyl-7-azaindole
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- Chemical Properties,Usage,Production
Synthesis
1000340-39-5
68-12-2
918515-16-9
Step 2: 3-bromo-4-chloro-7-azaindole (8 g, 34.632 mmol) was dissolved in THF (160 mL) and cooled to -78 °C. Under nitrogen protection, n-butyllithium (1.6 M in hexane, 50 mL, 79.63 mmol) was slowly added and stirred for 30 min keeping the temperature at -78 °C. Subsequently, N,N-dimethylformamide (5.056 g, 69.264 mmol) was slowly added and stirring was continued at -78 °C. The reaction mixture was gradually warmed to 25 °C and stirred at this temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (2 mL). The reaction mixture was concentrated under reduced pressure, treated with saturated aqueous ammonium chloride solution (28 mL), the precipitated solid was collected and dried under reduced pressure. Purification by silica gel column chromatography afforded 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (3.5 g, 52% yield) as a light yellow solid. The product was confirmed by 1H NMR (CDCl3): δ 12.6-12.8 (br s, 1H), 10.4-10.6 (s, 1H), 8.26-8.3 (d, 1H), 8.12-8.18 (s, 1H), 7.26-7.3 (d, 1H). The mass spectrum (ESI) showed a molecular ion peak (M+1) of 181, which is consistent with the calculated value of the molecular formula C8H5ClN2O.
References
[1] Patent: WO2008/12635, 2008, A2. Location in patent: Page/Page column 90
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- manufacturers
- Product
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- 918515-16-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22