1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
- CAS No.
- 1000340-39-5
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
- Synonyms
- 4-Chloro-3-bromo-7-azaindole;3-BROMO-4-CHLORO-7-AZAINDOLE;3-Bromo-4-chloro-7-azadindole;3-BROMO-4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-;3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine;3-Bromo-4-chloro-7-azaindole/3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine
- CBNumber
- CB71871781
- Molecular Formula
- C7H4BrClN2
- Formula Weight
- 231.48
- MOL File
- 1000340-39-5.mol
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- Property
- Melting point:
- 214-215°
- Density
- 1.878
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.31±0.40(Predicted)
- form
- solid
- color
- Brown to reddish brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00215
- Product name
- 3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $550
- Updated
- 2025/07/31
- Product number
- B690838
- Product name
- 3-Bromo-4-chloro-1h-pyrrolo[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H32-D-82
- Product name
- 3-Bromo-4-chloro-7-azaindole
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 3H32-D-82
- Product name
- 3-Bromo-4-chloro-7-azaindole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- X8457
- Product name
- 3-Bromo-4-chloro-7-azaindole
- Packaging
- 5g
- Price
- $157
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- Chemical Properties,Usage,Production
Synthesis
55052-28-3
1000340-39-5
General procedure for the synthesis of 3-bromo-4-chloro-7-azaindole from 4-chloro-7-azaindole: 1H-4-chloro-pyrrolo[2,3-b]pyridine (0.763 g, 5.0 mmol, 1.0 eq.) was dissolved in N,N-dimethylformamide (DMF, 7.5 mL, 1.5 mL/mmol of substrate), followed by addition of N-bromosuccinimide (NBS, 0.701 g, 5.25 mmol, 1.05 equiv). The reaction mixture was stirred overnight at room temperature protected from light. Upon completion of the reaction, ice water (25 mL, 5 mL/mmol substrate) was added to the mixture to quench the reaction and the precipitate precipitated was collected by filtration. The solid was washed four times with ice water (4 × 10 mL, 2 mL/mmol substrate) to remove residual DMF and by-products. The resulting solid was dried under high vacuum to afford 3-bromo-4-chloro-7-azaindole (0.861 g, 4.6 mmol) as an off-white solid in 92% yield. The melting point of the product was 236 °C (decomposition).1H NMR (300 MHz, DMSO-d6) δ: 7.21 (d, J = 4.2 Hz, 1H, H-5), 7.77 (s, 1H, H-2), 8.20 (d, J = 4.2 Hz, 1H, H-6), 12.35 (br.s, 1H, NH).13C NMR (75 MHz. DMSO-d6) δ: 101.1 (C-3), 113.7 (C-3a), 117.1 (C-5), 125.1 (C-2), 133.8 (C-4), 144.4 (C-6), 147.6 (C-7a). High-resolution mass spectrometry (HRMS, ESI): calculated value C7H5BrClN2 ([M + H]+) is 230.9319, measured value is 230.9319.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 248 - 267
[2] Patent: WO2008/5457, 2008, A2. Location in patent: Page/Page column 180
[3] Patent: WO2008/12635, 2008, A2. Location in patent: Page/Page column 90
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- manufacturers
- Product
- 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- 1000340-39-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22