3-Bromo-7-azaindole
- Product Name
- 3-Bromo-7-azaindole
- CAS No.
- 74420-15-8
- Chemical Name
- 3-Bromo-7-azaindole
- Synonyms
- 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;3-BROMO-7-AZAINDOLE;3-Bromo-7-azaindole 97%;3-BroMo-pyrrolo[2,3-b]pyridine;1H-PYRROLO[2,3-B]PYRIDINE, 3-BROMO-;3-Bromo-7-azaindole (3-bromo-1H-pyrrolo[2,3-b]pyridine）;3-broMo-1H-pyrrolo[2,3-b]pyridine 5-(trifluoroMethyl)-1H-iMidazole;1,2,3,4,5-Cyclopentanepentayl,1-[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(R)-(dimethylamino)phenylmethyl]-,ironsalt(2:5)
- CBNumber
- CB3295298
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 74420-15-8.mol
3-Bromo-7-azaindole Property
- Melting point:
- 185-189 °C
- Boiling point:
- 345.4±42.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Dichloromethane, Ethyl Acetate
- pka
- 5.89±0.20(Predicted)
- form
- Powder
- color
- White to brown
- CAS DataBase Reference
- 74420-15-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 694711
- Product name
- 3-Bromo-7-azaindole
- Purity
- 97%
- Packaging
- 1g
- Price
- $93.8
- Updated
- 2023/06/20
- Product number
- B3675
- Product name
- 3-Bromo-1H-pyrrolo[2,3-b]pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $74
- Updated
- 2024/03/01
- Product number
- B3675
- Product name
- 3-Bromo-1H-pyrrolo[2,3-b]pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $225
- Updated
- 2024/03/01
- Product number
- B680155
- Product name
- 3-Bromo-7-azaindole
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB19172
- Product name
- 3-Bromo-7-azaindole
- Packaging
- 2g
- Price
- $54
- Updated
- 2021/12/16
3-Bromo-7-azaindole Chemical Properties,Usage,Production
Chemical Properties
3-Bromo-7-azaindole is Yellow solid
Uses
3-Bromo-7-azaindole is a reagent used in the preparation of biologically active Azaindoles.
Uses
Useful starter in 7-azaindole chemistry
Synthesis
271-63-6
74420-15-8
General procedure for the synthesis of 3-bromo-1H-pyrrolo[2,3-b]pyridine from 7-azaindole: 100 mmol of 7-azaindole was dissolved in an appropriate amount of organic solvent and transferred to the reactor. Subsequently, 40 mmol of catalyst consisting of nickel(II) acetate mixed with triethanolamine borosilicate in a 3:1 ratio was added. The temperature of the reaction system was adjusted to 100 °C and the stirring speed was maintained at 90 rpm. The reaction was carried out by slowly passing 300 mmol of bromine gas and refluxed for 3 hours. After completion of the reaction, the target product 3-bromo-7-azaindole was obtained in 99.0% yield after purification.
References
[1] Patent: CN106349242, 2017, A. Location in patent: Paragraph 0033; 0034; 0035; 0036; 0037; 0038
[2] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 701 - 719
[3] Patent: WO2013/6634, 2013, A2. Location in patent: Paragraph 0379-0382
[4] Patent: WO2013/70606, 2013, A1. Location in patent: Paragraph 00383-00385
[5] Patent: WO2014/74471, 2014, A1. Location in patent: Paragraph 0268-0270
3-Bromo-7-azaindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-7-azaindole manufacturers
- Product
- 3-Bromo-7-azaindole 74420-15-8
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 90%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-22
- Product
- 3-Bromo-7-azaindole 74420-15-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11