5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Product Name: 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid
CAS No.: 800401-68-7
Chemical Name: 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid
Synonyms: 3-c]pyridine-2-carboxylic acid;5-Chloro-6-azaindole-2-carboxylic acid;5-Chloro-1H-pyrrolo[2,3-c]pyridin-2-carboxylic acid;5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid;1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-chloro-
CBNumber: CB41562358
Molecular Formula: C8H5ClN2O2
Formula Weight: 196.59
MOL File: 800401-68-7.mol

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5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid Property

Boiling point:: 500.9±45.0 °C(Predicted)
Density: 1.644
refractive index: 1.744
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.08±0.30(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C422188
Product name: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylicAcid
Packaging: 500mg
Price: $415
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148330
Product name: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylicacid
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148330
Product name: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylicacid
Packaging: 100mg
Price: $113
Updated: 2021/12/16

AK Scientific

Product number: W8526
Product name: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylicacid
Packaging: 100mg
Price: $131
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148330
Product name: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylicacid
Packaging: 250mg
Price: $225
Updated: 2021/12/16

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5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid Chemical Properties,Usage,Production

Uses

5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic Acid is a useful reactant for preparation of pyrrolopyridinecarboxylic acid amide as inhibitors of glycogen phosphorylase.

Synthesis

800401-67-6

800401-68-7

GENERAL METHOD: To a stirred solution of ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (1.3 mmol) in ethanol (12 mL) was added 2 M sodium hydroxide solution (1.7 mmol, 1.1 mL). The reaction mixture was heated to reflux for 1 h (for the synthesis of 5-chloro-6-azaindole-2-carboxylic acid) or 2 h (for the synthesis of other derivatives). After evaporation to remove the solvent, water (10 mL) was added and the pH was adjusted with acetic acid to 4.0. The precipitate was collected by filtration and the resulting solid was dried in a desiccator to give the target product 5-chloro-6-azaindole-2-carboxylic acid.

References

[1] Molecules, 2014, vol. 19, # 9, p. 13342 - 13357
[2] Patent: WO2006/59164, 2006, A2. Location in patent: Page/Page column 20-21
[3] Patent: WO2006/67532, 2006, A1. Location in patent: Page/Page column 19
[4] Patent: WO2005/85245, 2005, A1. Location in patent: Page/Page column 18
[5] Patent: WO2004/104001, 2004, A2. Location in patent: Page 35-36

5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid Suppliers

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View Lastest Price from 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 800401-68-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

800401-68-7, 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acidRelated Search:

5-Chloro-1H-pyrazolo[3,4-b]pyridine 5-Chloro-1H-pyrazolo[4,3-b]pyridine 1-(5-Bromo-7-azaindole)ethanone Ethanone, 1-(1H-pyrrolo[2,3-c]pyridin-3-yl)- (9CI) ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 4-BroMo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 5-AZAINDOLE-2-CARBOXYLIC ACID 3-Cyano-4-azaindole 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro- 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBALDEHYDE 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE

5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

3-c]pyridine-2-carboxylic acid

1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-chloro-

5-Chloro-6-azaindole-2-carboxylic acid

5-Chloro-1H-pyrrolo[2,3-c]pyridin-2-carboxylic acid

800401-68-7

CHIRAL CHEMICALS

Heterocycle-Pyridine series