4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Product Name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
- CAS No.
- 920965-87-3
- Chemical Name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Synonyms
- 4-Chloro-3-cyano-7-azaindole;4-Chloro-3-cyano-7-azaind...;4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 4-chloro-
- CBNumber
- CB12471243
- Molecular Formula
- C8H4ClN3
- Formula Weight
- 177.59
- MOL File
- 920965-87-3.mol
4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Property
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.58±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
- CAS DataBase Reference
- 920965-87-3
Safety
- RIDADR
- UN3439
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C380843
- Product name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC154467
- Product name
- 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC154467
- Product name
- 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR928099
- Product name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- Z5347
- Product name
- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Chemical Properties,Usage,Production
Synthesis
1004991-98-3
920965-87-3
Step 4: Compound C40 (3.2 g, 16.4 mmol) was suspended in dichloromethane (50 mL) at 25 °C, sulfoxide chloride (1.95 g, 16.4 mmol) was added, heated to reflux and stirred for 4 hours. Upon completion of the reaction, the mixture was cooled to 25 °C and filtered. The resulting solid was suspended in saturated sodium bicarbonate solution (10 mL) and stirred for 15 minutes. The solid was collected by filtration, washed with deionized water (50 mL) and subsequently dried under vacuum for 2 hours. The dried residue was suspended in acetonitrile (20 mL), refluxed for 1 h. The product was cooled to 25 °C, filtered and dried under reduced pressure to afford 4-chloro-3-cyano-1H-pyrrolo[2,3-b]pyridine (C41) as a light brown solid in 70% yield (2 g). The product was confirmed by infrared spectroscopy (KBr press) with major absorption peaks located at 3136, 2857, 2228, 1609, 1573, 1511, 1455, 1398, 1336, and 1312 cm^-1. NMR hydrogen spectra (CDCl3) showed δ: 13.1-13.3 (broad peaks, 1H), 8.6 (single peak, 1H), 8.3- 8.4 (double peak, 1H), 7.4-7.5 (double peak, 1H). Mass spectrometry analysis showed a molecular ion peak (M+H) of 178.2, which is consistent with the theoretically calculated value of C8H4ClN3.
References
[1] Patent: WO2008/12635, 2008, A2. Location in patent: Page/Page column 91
4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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