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1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

Product Name
1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS No.
942919-26-8
Chemical Name
1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Synonyms
EOS-61601;7-Azaindole-4-boronic aci...;2-dioxaborolan-2-yl)-1H-pyrrolo[2;7-Azaindole-4-boronic acid pinacol ester;1H-Pyrrolo[2,3-B]pyridine-4-boronic acid pinacol ester;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2...;4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-;4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine;4-(4,4,5,5-Tetramethyl-[1,3]dioxolan-2-yl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-
CBNumber
CB21871791
Molecular Formula
C13H17BN2O2
Formula Weight
244.1
MOL File
942919-26-8.mol
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1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Property

Density 
1.15
Flash point:
199℃
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
solid
pka
13.71±0.40(Predicted)
Appearance
Off-white to gray Solid
InChI
InChI=1S/C13H17BN2O2/c1-12(2)13(3,4)18-14(17-12)10-6-8-16-11-9(10)5-7-15-11/h5-8H,1-4H3,(H,15,16)
InChIKey
OYFHAWAVFVJOBN-UHFFFAOYSA-N
SMILES
C12NC=CC1=C(B1OC(C)(C)C(C)(C)O1)C=CN=2
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
UN2811
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
T302745
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
Packaging
1g
Price
$275
Updated
2021/12/16
AK Scientific
Product number
Y4781
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
Packaging
10g
Price
$571
Updated
2021/12/16
Matrix Scientific
Product number
068956
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
Purity
>95%
Packaging
5g
Price
$398
Updated
2021/12/16
ChemScene
Product number
CS-B0489
Product name
1H-Pyrrolo[2,3-b]pyridine,4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Purity
>98.0%
Packaging
10g
Price
$437
Updated
2021/12/16
SynQuest Laboratories
Product number
8H60-1-BH
Product name
4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
Purity
97.0%
Packaging
1g
Price
$490
Updated
2021/12/16
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1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is used in organic synthesis, in particular, that of novel potent and selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR inhibitors.

Synthesis

73183-34-3

55052-28-3

942919-26-8

The general procedure for the synthesis of 7-azaindole-4-boronic acid pinacol ester from pinacol ester of bis-boronic acid and 4-chloro-7-azaindole was as follows: 4-chloro-1H-pyrrolo[2,3-b]pyridine (457 mg, 3 mmol), palladium acetate (13.2 mg, 2 mol%), 2-(dicyclohexylphosphino)biphenyl (42 mg, 4 mol%), bis(pinacol co ) ethylborane (1.5 g, 6 mmol) and potassium acetate (590 mg, 6 mmol) were dissolved in degassed dioxane (10 mL) under nitrogen atmosphere. The reaction mixture was stirred at 100 °C for 5 h, subsequently cooled to room temperature and filtered through a thin diatomaceous earth pad (eluting with ethyl acetate). The filtrate was washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography to afford the target product 7-azaindole-4-boronic acid pinacol ester (690 mg, 94% yield).

References

[1] Patent: WO2009/93981, 2009, A1. Location in patent: Page/Page column 106
[2] Patent: WO2010/101302, 2010, A1. Location in patent: Page/Page column 186
[3] Patent: WO2008/139161, 2008, A1. Location in patent: Page/Page column 137

1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Suppliers

China 128 India 3 United States 9 Global 140
Zhengzhou HQ Material Co., Ltd.
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J & K SCIENTIFIC LTD.
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ITIC MEDCHEM(SUZHOU) CO.,LTD.
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0512-68323967 18015559028
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+86-512-69200360
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Energy Chemical
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 942919-26-8
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Career Henan Chemical Co
Product
1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 942919-26-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-100%
Supply Ability
1
Release date
2018-08-12

942919-26-8, 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-Related Search:

1-(5-Bromo-7-azaindole)ethanone Ethanone, 1-(1H-pyrrolo[2,3-c]pyridin-3-yl)- (9CI) ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 4-BroMo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 5-AZAINDOLE-2-CARBOXYLIC ACID 3-Cyano-4-azaindole 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro- 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID Indole-4-boronic acid 7-Azaindole

  • 1H-Pyrrolo[2,3-B]pyridine-4-boronic acid pinacol ester
  • 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 7-Azaindole-4-boronic acid pinacol ester
  • 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-
  • 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
  • 2-dioxaborolan-2-yl)-1H-pyrrolo[2
  • 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
  • 7-Azaindole-4-boronic aci...
  • EOS-61601
  • 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2...
  • 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-
  • 4-(4,4,5,5-Tetramethyl-[1,3]dioxolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine - [T0771]
  • 942919-26-8