Indole-4-boronic acid
- Product Name
- Indole-4-boronic acid
- CAS No.
- 220465-43-0
- Chemical Name
- Indole-4-boronic acid
- Synonyms
- 4-BORONOINDOLE;1H-INDOL-4-YLBORONIC ACID;AKOS BRN-0119;Indole-4-Boronic;4-Borono-1H-indole;4-INDOLEBORONIC ACID;ndole-4-boronic acid;INDOLE-4-BORONIC ACID;4-INDOLYLBORONIC ACID;1H-indol-4-ylboronicaci
- CBNumber
- CB5704374
- Molecular Formula
- C8H8BNO2
- Formula Weight
- 160.97
- MOL File
- 220465-43-0.mol
Indole-4-boronic acid Property
- Boiling point:
- 433.2±37.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 9.00±0.30(Predicted)
- form
- solid
- color
- Grey
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 220465-43-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-41-36/37/38
- Safety Statements
- 26-39-36/37/39
- Hazard Note
- Irritant/Keep Cold
- TSCA
- N
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 280425
- Product name
- Indole-4-boronic acid
- Packaging
- 100mg
- Price
- $406
- Updated
- 2021/12/16
- Product number
- I577750
- Product name
- Indole-4-boronicAcid
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- I577750
- Product name
- Indole-4-boronicAcid
- Packaging
- 2.5g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- BOR0001696
- Product name
- INDOLE-4-BORONIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1305.15
- Updated
- 2021/12/16
- Product number
- Q994
- Product name
- Indole-4-boronicacid
- Packaging
- 5g
- Price
- $380
- Updated
- 2021/12/16
Indole-4-boronic acid Chemical Properties,Usage,Production
Chemical Properties
Light yellow to grey powder
Uses
An arylboronic acid-based fluorescent biosensor.
Synthesis
52488-36-5
220465-43-0
The general procedure for the synthesis of 4-indoleboronic acid from 4-bromoindole was as follows: a mixture of potassium hydride (35% w/w, dispersed in mineral oil, 4.5 g, 39.3 mmol) and ether (105 mL) was added to a round-bottomed flask at 0 °C, followed by the slow addition of a solution of 4-bromo-1H-indole (7.0 g, 35.7 mmol) in ether (35 mL). The reaction mixture was transferred to a cold bath at -78 °C with continuous stirring for 45 min. A solution of tert-butyllithium (1.7 M in pentane, 46.2 mL, 78.5 mmol) pre-cooled to -78 °C was added to the reaction system via cannula. At -78 °C, tributyl borate (29 mL, 107.1 mmol) was added to the reaction slurry. The reaction system was gradually warmed to room temperature for 21 hours. Subsequently, the reaction mixture was placed in a 0 °C bath and phosphoric acid solution (350 mL, 1 M) was added. The mixture was stirred for 30 min and then extracted with ether, the organic phase was dried with anhydrous sodium sulfate and concentrated in vacuum to afford the target product 4-indoleboronic acid (4.01 g, 70% yield) as a beige solid. The product was characterized by 1H NMR ((CD3)2CO/15% D2O, 400 MHz) and mass spectrometry (MS).
References
[1] Journal of Organic Chemistry, 1999, vol. 64, # 4, p. 1372 - 1374
[2] Organic Letters, 2004, vol. 6, # 1, p. 3 - 5
[3] Patent: WO2009/73777, 2009, A1. Location in patent: Page/Page column 195-196
Indole-4-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Indole-4-boronic acid manufacturers
- Product
- Indole-4-boronic acid 220465-43-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- Indole-4-boronic acid 220465-43-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20
- Product
- Indole-4-boronic acid 220465-43-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20