Indole-3-carboxylic acid
- Product Name
- Indole-3-carboxylic acid
- CAS No.
- 771-50-6
- Chemical Name
- Indole-3-carboxylic acid
- Synonyms
- 1H-INDOLE-3-CARBOXYLIC ACID;ICO;3-Indoleformic acid;e-3-carboxyL;3-Indoleformic;3-CARBOXYINDOLE;3-indoleic acid;3-Indolecarboxylic;Indol-3-carbonsure;Indole-3-carboxylic
- CBNumber
- CB4416867
- Molecular Formula
- C9H7NO2
- Formula Weight
- 161.16
- MOL File
- 771-50-6.mol
Indole-3-carboxylic acid Property
- Melting point:
- 232-234 °C (dec.)(lit.)
- Boiling point:
- 287.44°C (rough estimate)
- Density
- 1.2480 (rough estimate)
- refractive index
- 1.5050 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in 95% Ethanol: 50 mg/ml, also soluble in methanol.
- pka
- 3.90±0.10(Predicted)
- form
- Powder
- color
- Light beige
- BRN
- 129435
- InChI
- InChI=1S/C9H7NO2/c11-9(12)7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,(H,11,12)
- InChIKey
- KMAKOBLIOCQGJP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(C(O)=O)=C1
- CAS DataBase Reference
- 771-50-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-21/22
- Safety Statements
- 22-24/25-36/37/39-26
- WGK Germany
- 3
- RTECS
- NK7882892
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 284734
- Product name
- Indole-3-carboxylic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 5g
- Price
- $55.8
- Updated
- 2024/03/01
- Product number
- 284734
- Product name
- Indole-3-carboxylic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 1g
- Price
- $35
- Updated
- 2023/06/20
- Product number
- I0028
- Product name
- Indole-3-carboxylic Acid
- Purity
- >98.0%(T)(HPLC)
- Packaging
- 5g
- Price
- $54
- Updated
- 2024/03/01
- Product number
- I0028
- Product name
- Indole-3-carboxylic Acid
- Purity
- >98.0%(T)(HPLC)
- Packaging
- 25g
- Price
- $156
- Updated
- 2024/03/01
- Product number
- A12634
- Product name
- Indole-3-carboxylic acid, 98%
- Packaging
- 1g
- Price
- $23.65
- Updated
- 2024/03/01
Indole-3-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
light beige crystalline powder (recrystallized from acetate-petroleum ether). Soluble in ethanol, ether, acetate, insoluble in boiling water, benzene, insoluble in petroleum ether.
Application
Indole-3-carboxylic Acid is a specific and competitive inhibitor of the potentiation of glycine of NMDA-gated current. Chemical reagent in the synthesis of thiadiazole derivatives used for anticancer activity.
Preparation
indole-3-carboxylic acid can be synthesized by the hydrolysis reaction of 3-trichloroacetyl indole: add 235g 3-trichloroacetyl indole into 1000ml methanol, slowly drop an appropriate amount of 50% KOH solution, heat up and reflux for 18 hours, cool to room temperature, The methanol was recovered by concentration, and the residual liquid was left; 1500 ml of water was added to the residual liquid, hydrochloric acid was added dropwise to adjust pH=3～4, and then filtered, and the solid obtained by filtration was dried to obtain 144g of indole-3-carboxylic acid crude product; The crude product was slurried with 100g of ethyl acetate for 25 minutes,filtered and dried to obtain indole-3-carboxylic acid (137g, yield 91.8%).
Definition
ChEBI: Indole-3-carboxylic acid is an indole-3-carboxylic acid carrying a carboxy group at position 3. It has a role as a human metabolite and a bacterial metabolite. It is a conjugate acid of an indole-3-carboxylate.
General Description
The structures of the derivatives of indole-3-carboxylic acid were studied using gas chromatography with high resolution mass spectrometry (GC-HRMS), ultra-high performance liquid chromatography in combination with high resolution tandem mass spectrometry (UHPLC-HRMS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FT-IR).
target
5-HT Receptor
Indole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Indole-3-carboxylic acid manufacturers
- Product
- Indole-3-carboxylic acid 771-50-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 1000
- Release date
- 2024-12-19
- Product
- Indole-3-carboxylic acid 771-50-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2022-09-29
- Product
- 3-Indoleformic acid 771-50-6
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-18