Indole-3-carboxylic acid
- Product Name
- Indole-3-carboxylic acid
- CAS No.
- 771-50-6
- Chemical Name
- Indole-3-carboxylic acid
- Synonyms
- 1H-INDOLE-3-CARBOXYLIC ACID;ICO;3-Indoleformic acid;e-3-carboxyL;3-Indoleformic;3-CARBOXYINDOLE;3-indoleic acid;3-Indolecarboxylic;Indol-3-carbonsure;Indole-3-carboxylic
- CBNumber
- CB4416867
- Molecular Formula
- C9H7NO2
- Formula Weight
- 161.16
- MOL File
- 771-50-6.mol
Indole-3-carboxylic acid Property
- Melting point:
- 232-234 °C (dec.)(lit.)
- Boiling point:
- 287.44°C (rough estimate)
- Density
- 1.2480 (rough estimate)
- refractive index
- 1.5050 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in 95% Ethanol: 50 mg/ml, also soluble in methanol.
- pka
- 3.90±0.10(Predicted)
- form
- Powder
- color
- Light beige
- BRN
- 129435
- InChI
- InChI=1S/C9H7NO2/c11-9(12)7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,(H,11,12)
- InChIKey
- KMAKOBLIOCQGJP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(C(O)=O)=C1
- CAS DataBase Reference
- 771-50-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-21/22
- Safety Statements
- 22-24/25-36/37/39-26
- WGK Germany
- 3
- RTECS
- NK7882892
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- Y0000618
- Product name
- Tropisetron impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10 mg
- Price
- $228
- Updated
- 2025/07/31
- Product number
- 284734
- Product name
- Indole-3-carboxylic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 5g
- Price
- $57.5
- Updated
- 2025/07/31
- Product number
- 284734
- Product name
- Indole-3-carboxylic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 1g
- Price
- $35
- Updated
- 2023/06/20
- Product number
- I0028
- Product name
- Indole-3-carboxylic Acid
- Purity
- >98.0%(T)(HPLC)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- I0028
- Product name
- Indole-3-carboxylic Acid
- Purity
- >98.0%(T)(HPLC)
- Packaging
- 25g
- Price
- $156
- Updated
- 2025/07/31
Indole-3-carboxylic acid Chemical Properties,Usage,Production
Description
Indole-3-carboxylic acid is a plant metabolite derived from tryptophan that has been found in Arabidopsis and has diverse biological activities.1,2,3,4 It induces resistance in Arabidopsis against the plant necrotrophic fungus P. cucumerina when applied as a soil-drenching solution at a concentration of 150 µM prior to infection.2 Indole-3-carboxylic acid is cytotoxic to A549 human lung and MCF-7 human breast cancer cells (EC50s = 4.6 and 12.9 µg/ml, respectively) and inhibits HIV replication in infected H9 lymphocytes (IC50 = 16.4 µg/ml).3 Indole-3-carboxylic acid has also been used as a precursor in the synthesis of substituted thiadiazoles with anticancer activity.4WARNING This product is not for human or veterinary use.
Chemical Properties
light beige crystalline powder (recrystallized from acetate-petroleum ether). Soluble in ethanol, ether, acetate, insoluble in boiling water, benzene, insoluble in petroleum ether.
Application
Indole-3-carboxylic Acid is a specific and competitive inhibitor of the potentiation of glycine of NMDA-gated current. Chemical reagent in the synthesis of thiadiazole derivatives used for anticancer activity.
Preparation
indole-3-carboxylic acid can be synthesized by the hydrolysis reaction of 3-trichloroacetyl indole: add 235g 3-trichloroacetyl indole into 1000ml methanol, slowly drop an appropriate amount of 50% KOH solution, heat up and reflux for 18 hours, cool to room temperature, The methanol was recovered by concentration, and the residual liquid was left; 1500 ml of water was added to the residual liquid, hydrochloric acid was added dropwise to adjust pH=3～4, and then filtered, and the solid obtained by filtration was dried to obtain 144g of indole-3-carboxylic acid crude product; The crude product was slurried with 100g of ethyl acetate for 25 minutes,filtered and dried to obtain indole-3-carboxylic acid (137g, yield 91.8%).
Definition
ChEBI: Indole-3-carboxylic acid is an indole-3-carboxylic acid carrying a carboxy group at position 3. It has a role as a human metabolite and a bacterial metabolite. It is a conjugate acid of an indole-3-carboxylate.
General Description
The structures of the derivatives of indole-3-carboxylic acid were studied using gas chromatography with high resolution mass spectrometry (GC-HRMS), ultra-high performance liquid chromatography in combination with high resolution tandem mass spectrometry (UHPLC-HRMS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FT-IR).
target
5-HT Receptor
Indole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Indole-3-carboxylic acid manufacturers
- Product
- Indole-3-carboxylic acid 771-50-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2022-09-29
- Product
- 3-Indoleformic acid 771-50-6
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-13
- Product
- 3-Indoleformic acid 771-50-6
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-18