ChemicalBook > CAS DataBase List > Indole-3-carboxylic acid

Indole-3-carboxylic acid

Product Name
Indole-3-carboxylic acid
CAS No.
771-50-6
Chemical Name
Indole-3-carboxylic acid
Synonyms
1H-INDOLE-3-CARBOXYLIC ACID;ICO;3-Indoleformic acid;e-3-carboxyL;3-Indoleformic;3-CARBOXYINDOLE;3-indoleic acid;3-Indolecarboxylic;Indol-3-carbonsure;Indole-3-carboxylic
CBNumber
CB4416867
Molecular Formula
C9H7NO2
Formula Weight
161.16
MOL File
771-50-6.mol
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Indole-3-carboxylic acid Property

Melting point:
232-234 °C (dec.)(lit.)
Boiling point:
287.44°C (rough estimate)
Density 
1.2480 (rough estimate)
refractive index 
1.5050 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in 95% Ethanol: 50 mg/ml, also soluble in methanol.
form 
Powder
pka
3.90±0.10(Predicted)
color 
Light beige
BRN 
129435
InChIKey
KMAKOBLIOCQGJP-UHFFFAOYSA-N
CAS DataBase Reference
771-50-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-21/22
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
RTECS 
NK7882892
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
284734
Product name
Indole-3-carboxylic acid
Purity
ReagentPlus , 99%
Packaging
5g
Price
$55.8
Updated
2024/03/01
Sigma-Aldrich
Product number
284734
Product name
Indole-3-carboxylic acid
Purity
ReagentPlus , 99%
Packaging
1g
Price
$35
Updated
2023/06/20
TCI Chemical
Product number
I0028
Product name
Indole-3-carboxylic Acid
Purity
>98.0%(T)(HPLC)
Packaging
5g
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
I0028
Product name
Indole-3-carboxylic Acid
Purity
>98.0%(T)(HPLC)
Packaging
25g
Price
$156
Updated
2024/03/01
Alfa Aesar
Product number
A12634
Product name
Indole-3-carboxylic acid, 98%
Packaging
1g
Price
$23.65
Updated
2024/03/01
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Indole-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

light beige crystalline powder (recrystallized from acetate-petroleum ether). Soluble in ethanol, ether, acetate, insoluble in boiling water, benzene, insoluble in petroleum ether.

Application

Indole-3-carboxylic Acid is a specific and competitive inhibitor of the potentiation of glycine of NMDA-gated current. Chemical reagent in the synthesis of thiadiazole derivatives used for anticancer activity.

Preparation

indole-3-carboxylic acid can be synthesized by the hydrolysis reaction of 3-trichloroacetyl indole: add 235g 3-trichloroacetyl indole into 1000ml methanol, slowly drop an appropriate amount of 50% KOH solution, heat up and reflux for 18 hours, cool to room temperature, The methanol was recovered by concentration, and the residual liquid was left; 1500 ml of water was added to the residual liquid, hydrochloric acid was added dropwise to adjust pH=3～4, and then filtered, and the solid obtained by filtration was dried to obtain 144g of indole-3-carboxylic acid crude product; The crude product was slurried with 100g of ethyl acetate for 25 minutes,filtered and dried to obtain indole-3-carboxylic acid (137g, yield 91.8%).

Definition

ChEBI: Indole-3-carboxylic acid is an indole-3-carboxylic acid carrying a carboxy group at position 3. It has a role as a human metabolite and a bacterial metabolite. It is a conjugate acid of an indole-3-carboxylate.

General Description

The structures of the derivatives of indole-3-carboxylic acid were studied using gas chromatography with high resolution mass spectrometry (GC-HRMS), ultra-high performance liquid chromatography in combination with high resolution tandem mass spectrometry (UHPLC-HRMS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FT-IR).

target

5-HT Receptor

Indole-3-carboxylic acid Preparation Products And Raw materials

Raw materials

4-(Benzyloxy)pyridine N-oxide

Preparation Products

1-Methyl-1H-indole-3-carboxylic acid Indole-2-carboxylic acid
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View Lastest Price from Indole-3-carboxylic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Indole-3-carboxylic acid 771-50-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1000kg
Release date
2022-09-29
Hebei Weibang Biotechnology Co., Ltd
Product
3-Indoleformic acid 771-50-6
Price
US $25.00/ASSAYS
Min. Order
100ASSAYS
Purity
99.5%
Supply Ability
100 mt
Release date
2024-11-18
Hebei Chuanghai Biotechnology Co,.LTD
Product
Indole-3-carboxylic acid 771-50-6
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-13

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