Description
ChemicalBook > CAS DataBase List > Folic acid

Folic acid

Description
Product Name
Folic acid
CAS No.
59-30-3
Chemical Name
Folic acid
Synonyms
PGA;Folan;folic;Aspol;PTEGLU;FOLSAN;Folate;Folbal;Folsav;VM/PGA
CBNumber
CB5100903
Molecular Formula
C19H19N7O6
Formula Weight
441.4
MOL File
59-30-3.mol
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Folic acid Property

Melting point:
250 °C
alpha 
20 º (c=1, 0.1N NaOH)
Boiling point:
552.35°C (rough estimate)
Density 
1.4704 (rough estimate)
refractive index 
1.6800 (estimate)
storage temp. 
2-8°C
solubility 
boiling water: soluble1%
pka
pKa 2.5 (Uncertain)
form 
Crystalline Powder
color 
Yellow to orange
Odor
Odorless
PH Range
4
Water Solubility 
1.6 mg/L (25 ºC)
Merck 
14,4221
BRN 
100781
Stability:
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
InChIKey
OVBPIULPVIDEAO-LBPRGKRZSA-N
CAS DataBase Reference
59-30-3(CAS DataBase Reference)
NIST Chemistry Reference
Folic acid(59-30-3)
EPA Substance Registry System
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)
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Safety

Risk Statements 
33-62-68
Safety Statements 
24/25
WGK Germany 
1
RTECS 
LP5425000
8
TSCA 
Yes
HS Code 
29362900
Hazardous Substances Data
59-30-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F7876
Product name
Folic acid
Purity
≥97%
Packaging
1g
Price
$18.4
Updated
2021/03/22
Sigma-Aldrich
Product number
47866
Product name
Folic acid
Purity
analytical standard
Packaging
500 mg
Price
$27.8
Updated
2021/03/22
Sigma-Aldrich
Product number
1286005
Product name
Folic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$371
Updated
2021/03/22
TCI Chemical
Product number
F0043
Product name
Folic Acid Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$55
Updated
2021/03/22
Alfa Aesar
Product number
J60833
Product name
Folic acid, crystalline
Packaging
25g
Price
$66.3
Updated
2021/03/22
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Folic acid Chemical Properties,Usage,Production

Description

Folic acid (folate) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red blood cell generation. In women pregnancy, folate can effectively prevent neural tube defects in the baby. It plays important role in fertility through contributing to spermatogenesis. It can also reduce the incidence of heart disease, stroke and cancer. 
Folate deficiency may lead to various kinds of diseases including glossitis, diarrhea, depression, confusion, anemia, and fetal neural tube defectsand brain defects (during pregnancy). Other symptoms may include fatigue, gray hair, mouth sores, poor growth, and swollen tongue.

Description

In the 1930s, brewer’s yeast was found to prevent anemia. Folic acid was later discovered to be the nutrient responsible for this effect and was purified in 1941 by Mitchell and coworkers (Mitchell et al., 1941). Folate is needed for biosynthesis of purines and thymidine for DNA and RNA synthesis in all cells. It is also involved in metabolism of some of the amino acids needed for protein synthesis, especially the conversions of serine to glycine and homocysteine to methionine. This makes the nutrient especially important during periods of rapid cell division, such as in pregnancy. Folate is also involved in transfer of one-carbon groups for methylation reactions. The role of folate in cell division was capitalized upon in the synthesis of aminopterin, a folate antagonist, which was one of the first anticancer drugs produced.

Chemical Properties

orange to yellow crystalline powder

Physical properties

The folates include a large number of chemically related species, each differing with respect to the various substituents possible at three sites on the pteroylglutamic acid basic structure. More than 170 different folates are theoretically possible. Not all of these occur in nature; but it has been estimated that as many as 100 different forms are found in animals. The folates from most natural sources usually have a single carbon unit at N-5 and/or N-10; these forms participate in the metabolism of the single-carbon pool.
Folic acid (pteroylmonoglutamic acid) is an orange-yellow crystalline substance that is soluble in water but insoluble in ethanol or less polar organic solvents. It is unstable to light, to acidic or alkaline conditions, to reducing agents, and, except in dry form, to heat. It is reduced in vivo enzymatically (or in vitro with a reductant such as dithionite) first to 7,8-dihydrofolic acid (FH2) and then to FH4; both of these compounds are unstable in aerobic environments and must be protected by the pres ence of an antioxidant (e.g., ascorbic acid, 2-mer
Two derivatives of folic acid, each having an amino group in the place of the hydroxyl at C-4, are folate antagonists of biomedical use: aminopterin (4-aminofolic acid) and methotrexate (4-amino-N10-methylfolic acid). Aminopterin is used as a rodenticide; methotrexate is an antineoplastic agent.

Originator

Folvite, Lederle, US ,1946

Occurrence

Synthetic

Uses

folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.

Uses

Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.

Uses

Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.

Uses

A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Uses

hematopoietic vitamin

Definition

ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

Manufacturing Process

The following description is taken from US Patent 2,956,057.
100 grams of 1,3,3-trichloroacetone are heated on a boiling water bath and 95 grams of bromine are added thereto in drops while being stirred and the stirring is continued for about 1 hour. The resulting reaction solution is distilled under reduced pressure. 115 grams of 1-bromo-1,3,3- trichloroacetone are obtained having a boiling point of 85° to 95°C/17 mm (Hg).
For the preparation of the hydrate, 100 grams of water are added to 100 grams of 1bromo-1,3,3-trichloroacetone, which is agitated and cooled. A white scaly crystal of hydrate of 1-bromo-1,3,3-trichloroacetone is obtained (100 grams), having a melting point of 52° to 53°C.
8.9 grams of 2,4,5-triamino-6-hydroxypyrimidine hydrochloride and 8 grams of p-aminobenzoylglutamic acid are dissolved in 400 cc warm water, which is cooled at 35° to 27°C and adjusted to pH 4 by using 20% caustic soda solution. To this solution was simultaneously added dropwise a solution obtained by dissolving 13.4 grams of 1-bromo-1,3,3-trichloroacetone hydrate in 90 cc of 50% methanol and 24 grams of 35% aqueous sodium bisulfite solution over a period of approximately 2 hours. During this period, in order to maintain the pH value of the reaction solution at 4 to 5, 20% caustic soda solution is added from time to time. The precipitate, formed by stirring for 5 hours after dropping was finished, is filtered, and the filtrated precipitate is refined; 5.6 grams of pure pteroylglutamic acid is obtained.

Therapeutic Function

Treatment of B vitamin (folacin) deficiency

General Description

Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

Air & Water Reactions

Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

Reactivity Profile

Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.

Fire Hazard

Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Folic acid is used to treat folic acid deficiency in dogs, cats, and horses (theoretically in other animal species as well) often due to small intestinal disease. Cats with exocrine pancreatic insufficiency appear to be most at risk for folate and cobalamin deficiencies secondary to malabsorption of folic acid in the diet. Dogs with exocrine pancreatic insufficiency often are noted to have increased folate levels secondary to overgrowths of folate-synthesizing bacteria in the proximal small intestine. Chronic administration of dihydrofolate reductase inhibiting drugs such as pyrimethamine, ormetoprim or trimethoprim can potentially lead to reduced activated folic acid (tetrahydrofolic acid); folic acid supplementation is sometimes prescribed in an attempt to alleviate this situation.

Purification Methods

If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

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Folic acid Suppliers

HENGSHUI HAOYE CHEMICAL CO.,LTD.
Tel
0318-2102300-
Fax
0318-2103390
Email
hy@chemcoms.com
Country
China
ProdList
215
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Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel
;
Fax
025-84209270
Email
wgp@nanjing-pharmaceutical.com;wgp@nanjing-pharmaceutical.com
Country
China
ProdList
106
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Jinan Rouse Industry Co., Ltd.
Tel
0531-82929600-
Fax
053182921652
Email
sale@rousechem.com
Country
China
ProdList
165
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58
Syntechem Co.,Ltd.
Tel
519-88298820-
Fax
86-519-83850735
Email
info@syntechem.com
Country
China
ProdList
255
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Anhui Dali Biotechnology Co. , Ltd.
Tel
130-13138463- ;
Fax
0563-6601666
Email
3383822427@qq.com;443108339@qq.com
Country
China
ProdList
364
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ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
26597
Advantage
56
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586-
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
145
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58
Changzhou Qiyu Biotechnology Co., Ltd.
Email
zzyqqq@163.com
Country
China
ProdList
52
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58
Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
350
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69
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
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View Lastest Price from Folic acid manufacturers

Wuhan Aoliqisi New Material Technology Co., Ltd.
Product
folic acid 59-30-3
Price
US $1.00/g
Min. Order
1000g
Purity
99%
Supply Ability
20ton/month
Release date
2021-07-13
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Folic acid 59-30-3
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-17
Wuhan wingroup Pharmaceutical Co., Ltd
Product
Folic acid 59-30-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-07-12

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