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DL-α-Tocopherol

Product Name
DL-α-Tocopherol
CAS No.
10191-41-0
Chemical Name
DL-α-Tocopherol
Synonyms
3,;8-(4;ecyl)-;ephanyl;TGF-β-3;hTGF-β3;A-TOCOPHEROL;DL-VITAMIN E;4-BroMo-2-(5;FIIN-​
CBNumber
CB5275357
Molecular Formula
C29H50O2
Formula Weight
430.71
MOL File
10191-41-0.mol
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DL-α-Tocopherol Property

Melting point:
2-4°C
alpha 
[α]D20 - 0.02 - +0.02゜ (neat)
Boiling point:
200-220°C 0,1mm
Density 
0.950 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.506
Flash point:
240°C
storage temp. 
2-8°C
solubility 
H2O: insoluble
form 
Pale yellow oil
pka
11.40±0.40(Predicted)
Water Solubility 
Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive 
Light Sensitive
Merck 
14,9495
BRN 
94012
InChIKey
GVJHHUAWPYXKBD-IEOSBIPESA-N
CAS DataBase Reference
10191-41-0(CAS DataBase Reference)
EPA Substance Registry System
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- (10191-41-0)
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Safety

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-37/39-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
RTECS 
GA8746000
8-10-23
TSCA 
Yes
HS Code 
29362800
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
258024
Product name
α-Tocopherol
Purity
≥95.5%
Packaging
5g
Price
$13
Updated
2020/08/18
Sigma-Aldrich
Product number
V-020
Product name
(±)−α−Tocopherol (Vitamin E) solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1 mL
Price
$58.5
Updated
2021/03/22
Sigma-Aldrich
Product number
1667600
Product name
Alpha Tocopherol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$371
Updated
2020/08/18
Sigma-Aldrich
Product number
5.00949
Product name
all-rac-α-Tocopherol
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,USP,E 307
Packaging
5 kg
Price
$1260
Updated
2021/03/22
Sigma-Aldrich
Product number
5.00949
Product name
all-rac-α-Tocopherol
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,USP,E 307
Packaging
20 kg
Price
$4370
Updated
2021/03/22
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DL-α-Tocopherol Chemical Properties,Usage,Production

Chemical Properties

1mg = 1.1 IU

Chemical Properties

Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.

Uses

dl-α-Tocopherol is the racemic analog of α-Tocopherol (T526125), the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils. dl-α-Tocopherol is an antioxidant that protects cell membrane lipids from oxidative damage.

Production Methods

Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.

Pharmaceutical Applications

Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants.
Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate.
Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations.
d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.

Safety

Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used.
Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis.
The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet.
The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.

storage

Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants.
Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.

Purification Methods

Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]

Incompatibilities

Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

DL-α-Tocopherol Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-α-Tocopherol Suppliers

Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3582
Advantage
66
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40265
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
2000
Advantage
65
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30160
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
kennyrong@hwrkchemical.com
Country
China
ProdList
17296
Advantage
55
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44043
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12282
Advantage
60
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View Lastest Price from DL-α-Tocopherol manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
DL-α-Tocopherol 10191-41-0
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-03-11
hdzhl biotechnology co., ltd
Product
Dl-Alpha Tocopherol (Vitamin E) 10191-41-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200 tons
Release date
2019-05-29
career henan chemical co
Product
DL-α-Tocopherol 10191-41-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-03

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