ChemicalBook > CAS DataBase List > Vitamin E

Vitamin E

Product Name
Vitamin E
CAS No.
59-02-9
Chemical Name
Vitamin E
Synonyms
α-Tocopherol;VITAMIN E OIL;D-ALPHA-TOCOPHEROL;tocopheryl;VITAMINE E;D-α-Tocopherol;D-A-TOCOPHEROL;All-rac-alpha-tocopherol for peak identification CRS;verrol;covi-ox
CBNumber
CB7132531
Molecular Formula
C29H50O2
Formula Weight
430.71
MOL File
59-02-9.mol
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Vitamin E Property

Melting point:
2.5-3.5 °C
alpha 
24 º (c=2, in isooctane 25 ºC)
Boiling point:
200-220 °C0.1 mm Hg(lit.)
Density 
0.95 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.505(lit.)
Flash point:
253 °C
storage temp. 
-20°C
solubility 
Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol, in methylene chloride and in fatty oils.
pka
11.40±0.40(Predicted)
form 
oil
color 
clear yellow
Odor
lt. yel. to red visc. oil, nearly odorless
Water Solubility 
INSOLUBLE
Merck 
14,9495
BRN 
4712525
Stability:
Stable. Combustible. May be sensitive to light and air. Incompatible with strong oxidizing agents.
LogP
10.962 (est)
CAS DataBase Reference
59-02-9(CAS DataBase Reference)
NIST Chemistry Reference
Vitamin e(59-02-9)
EPA Substance Registry System
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)- (59-02-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-37/39-26
WGK Germany 
1
RTECS 
DJ2900000
8-10-23
HS Code 
29362800
Hazardous Substances Data
59-02-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3634
Product name
(+)-α-Tocopherol
Purity
from vegetable oil, Type V, ~1000?IU/g
Packaging
10G
Price
$25.2
Updated
2023/06/20
Sigma-Aldrich
Product number
T3634
Product name
(+)-α-Tocopherol
Purity
from vegetable oil, Type V, ~1000?IU/g
Packaging
100G
Price
$133
Updated
2023/06/20
Sigma-Aldrich
Product number
T1539
Product name
(+)-α-Tocopherol
Purity
Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000?IU/g
Packaging
25G
Price
$54.9
Updated
2023/06/20
Sigma-Aldrich
Product number
T1539
Product name
(+)-α-Tocopherol
Purity
Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000?IU/g
Packaging
100G
Price
$169
Updated
2023/06/20
TCI Chemical
Product number
T2309
Product name
D-α-Tocopherol
Purity
>97.0%(GC)
Packaging
25g
Price
$92
Updated
2024/03/01
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Vitamin E Chemical Properties,Usage,Production

Chemical Properties

light yellow liquid

Chemical Properties

VITAMIN E is sometimes referred to as the antisterility vitamin, factor X (an earlier designation), chemically vitamin E is alphatocopherol. Active analogues and related compounds include: dl-α-Tocopherol; 1-α-tocopherol; esters (succinate, acetate, phosphate), and β, ζ 1, ζ 2- tocopherols. The principal physiological forms are D-a-tocopherol, tocopheronolactone, and their phosphate esters.

Originator

Doppelherz,Queisser Pharma,Germany

Uses

vitamin E, antioxidant

Uses

α-Tocopherol is the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.

Uses

Use in insect cell culture applications as an antioxidant.

Definition

ChEBI: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.

Manufacturing Process

Manufacturing process for Vitamin E, that is, α-tocopherol (5,7,8-trimethyltocol) in the past has been accomplished primarily by reacting trimethylhydroquinone (TMHQ) with isophytol (3,7,11,15-tetramethylhexadec-1-en-3-ol) or phytol (3,7,11,15-tetramethylhexadec-2-en-1-ol) in a condensation reaction. The reaction is well known and has been practiced for many years (StallaBourdillon, Ind. Chim. Belg., 35, 13 (1970); "The Vitamins" Vol. 5, pages 168- 223, Academic Press, New York, 1967). The Synthesis of Vitamin E includes these steps as follows: Rearrangement to C15 Acetylene; Saponification of the C20 Dienol Acetate to Dehydrophytol;Condensation of Dehydrophytol with TMHQ to yield Dehydro-Vitamin E.

Therapeutic Function

Antioxidant

General Description

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

Health Hazard

The physiological functions of vitamin E substances include: (1) bio logical antioxidant; (2) normal growth maintenance; (3) protects unsaturated fatty acids and membrane structures; (4) aids intestinal absorption of unsaturated fatty acids; (5) maintains normal muscle metabolism; (6) maintains integrity of vascular system and central nervous system; (7) detoxifying agent; and (8) maintains kidney tubules, lungs, genital structures, liver, and red blood cell membranes.
In livestock and laboratory animals, a deficiency of vitamin E substances may cause degeneration of reproductive tissues, muscular dystrophy, encephalomalacia, and liver necrosis. Considerable research is required to fully determine supplementation of livestock diets unless typical symptoms of a deficiency appear. Symptoms have appeared where there are selenium deficiencies in the soil and where there are excessive levels of nitrates in the soil. “White muscle” is the term used to describe a condition of muscular dystrophy in cattle.

Biochem/physiol Actions

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Vitamin E is a viscous yellow oil which is distilled at high vacuum. It has max at 294nm (E1cm 1% 71). It is oxygen and light sensitive and is best stored as its stable D--acetate [58-95-7] which is purified by evaporative distillation at b 180-200o(bath temperature)/0.7mm, and has [] D 25 +3.3o (c 5.1, EtOH). It forms needles at -30o and has m 26.5-27.5o, [] D 25 +0.25o (c 10, CHCl3). [NMR: Cohen et al. Helv Chim Acta 6 4 1158 1981, Burton & Ingold Acc Chem Res 1 9 194 1986, Karrer et al. Helv Chim Acta 2 1 520 1938, Robeson J Am Chem Soc, 64 1487 1942, 65 1660 1943.] Of the eight isomers the D--isomer is the most active. [See W. Friedrich “Vitamins” Walter de Guyter Publ, Berlin 1988.] [Beilstein 17/4 V 168.]

Vitamin E Preparation Products And Raw materials

Raw materials

Preparation Products

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Vitamin E Suppliers

Zhejiang kangpuda biotechnology co. LTD
Tel
573-88718797 18105830567
Fax
86-573-88718796
Email
1069963279@qq.com
Country
CHINA
ProdList
1
Advantage
58
Hebei Zhentian Food Additives Co., Ltd.
Tel
0319-5925599 13373390591
Fax
0319 5925599
Email
13933732699@163.com
Country
China
ProdList
12185
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
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View Lastest Price from Vitamin E manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Vitamin E 59-02-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-04-23
Hebei Saisier Technology Co., LTD
Product
Vitamin E 59-02-9
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
500KG/Month
Release date
2024-09-18
Hebei Chuanghai Biotechnology Co,.LTD
Product
Vitamin E 59-02-9
Price
US $5.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2024-08-21

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