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D-α-Tocopherol succinate

Product Name
D-α-Tocopherol succinate
CAS No.
4345-03-3
Chemical Name
D-α-Tocopherol succinate
Synonyms
VE;VITAMIN E SUCCINATE;VES;TOCOPHEROL SUCCINATE;α-Tocopheryl Succinate;D-A-TOCOPHEROL SUCCINATE;ALPHA-TOCOPHERYL SUCCINATE;D-alpha-Tocopheryl;D-ALPHA-TOCOPHERYL SUCCINATE;D-ALPHA-TOCOPHEROL SUCCINATE
CBNumber
CB8483476
Molecular Formula
C33H54O5
Formula Weight
530.78
MOL File
4345-03-3.mol
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D-α-Tocopherol succinate Property

Melting point:
~76 °C(lit.)
Boiling point:
625.8±55.0 °C(Predicted)
Density 
1.002±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 20℃
storage temp. 
-20°C
solubility 
Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.
form 
Solid
pka
4.35±0.17(Predicted)
color 
White or off-white
Odor
Little or no odor
λmax
286nm(EtOH)(lit.)
Merck 
14,9495
BRN 
4038233
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP
12 at 25℃
CAS DataBase Reference
4345-03-3(CAS DataBase Reference)
EPA Substance Registry System
D-.alpha.-Tocopheryl acid succinate (4345-03-3)
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Safety

WGK Germany 
1
RTECS 
EJ9984000
8-10-23
HS Code 
2936280000
Toxicity
LD50 oral in rat: > 7gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3126
Product name
D-α-Tocopherol succinate
Purity
semisynthetic, 1210?IU/g
Packaging
5G
Price
$34.32
Updated
2024/03/01
Sigma-Aldrich
Product number
T3126
Product name
D-α-Tocopherol succinate
Purity
semisynthetic, 1210?IU/g
Packaging
25G
Price
$58.4
Updated
2024/03/01
Sigma-Aldrich
Product number
T3126
Product name
D-α-Tocopherol succinate
Purity
semisynthetic, 1210?IU/g
Packaging
100G
Price
$265.2
Updated
2024/03/01
Sigma-Aldrich
Product number
95255
Product name
D-α-Tocopherol succinate
Purity
BioXtra, ≥98.0% (HPLC)
Packaging
100MG
Price
$313
Updated
2024/03/01
Sigma-Aldrich
Product number
47782
Product name
D-α-Tocopherol succinate
Purity
analytical standard
Packaging
100MG
Price
$36
Updated
2024/03/01
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D-α-Tocopherol succinate Chemical Properties,Usage,Production

Description

Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2?Tocopherol succinate induces apoptosis in human gastric cancer cells3?and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

Chemical Properties

Off-White to Pale Yellow Solid

Uses

A potent antioxidant tocopherol

Uses

A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

Definition

ChEBI: Tocopherol succinate is a tocol and a hemisuccinate.

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Tocopherol exhibits antioxidant property by protecting the cells and membranes from oxidative stress. In plants, high levels of α-tocopherol leads to plant stress tolerance whereas low levels is associated with oxidative stress. In humans, tocopherol prevents cancer, premature aging, atherosclerosis, arthritis caused due to free radicals. Vitamin E succinate (VES) is an anti-tumor analog of vitamin E.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

References

1) Singh?et al. (2010),?Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor; Int. J. Radiation Biol.,?86?12 2) Singh?et al. (2009),?Tocopherol succinate: a promising radiation countermeasure; Immunopharmacol.,?9?1423 3) Wu?et al. (2004),?c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells; J. Gastroenterol.,?10?1110 4) Stapelberg?et al. (2004),?alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors; Biochem. Biophys. Res. Commun.,?318?636 5) Swettenham?et al. (2005),?Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system; J. Neurochem.,?94?1448

D-α-Tocopherol succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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D-α-Tocopherol succinate Suppliers

-Jiangsu XiXin Vitamin Co., Ltd.
Tel
0527-83969698 15051038808
Fax
0527-83636888
Email
sales@xixingroup.com
Country
China
ProdList
1
Advantage
58
Hebei Zhentian Food Additives Co., Ltd.
Tel
0319-5925599 13373390591
Fax
0319 5925599
Email
13933732699@163.com
Country
China
ProdList
12185
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
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View Lastest Price from D-α-Tocopherol succinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-α-Tocopherol succinate 4345-03-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-04-07
Hebei Kingfiner Technology Development Co.Ltd
Product
D-α-Tocopherol succinate 4345-03-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2024-05-24
Hebei Weibang Biotechnology Co., Ltd
Product
Vitamin E succinate 4345-03-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-09

4345-03-3, D-α-Tocopherol succinateRelated Search:


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