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Thiamine chloride

Product Name
Thiamine chloride
CAS No.
59-43-8
Chemical Name
Thiamine chloride
Synonyms
Vitamin B1;thiamin;VITAMIN B1(THIAMINE)(BASF)(SH);aneurine;ViatmineB1;THIAMIMEMONOCHLORIDE;VITAMIN B1(THIAMINE)(SH);Thiamine chloride vitamin B1;Vitamin B1 Mononitrate (Mono);b-amin
CBNumber
CB0154385
Molecular Formula
C12H17ClN4OS
Formula Weight
300.81
MOL File
59-43-8.mol
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Thiamine chloride Property

Melting point:
248 °C (decomp)
Density 
1.3175 (rough estimate)
refractive index 
1.5630 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO : 6 mg/mL (19.95 mM)
InChI
InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1
InChIKey
MYVIATVLJGTBFV-UHFFFAOYSA-M
SMILES
O([H])CCC1=C(C)[N+](=CS1)CC1C=NC(=NC=1N)C.[Cl-]
LogP
-3.930 (est)
CAS DataBase Reference
59-43-8(CAS DataBase Reference)
EPA Substance Registry System
Thiamine (59-43-8)
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Safety

Hazardous Substances Data
59-43-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
097639
Product name
3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride
Purity
95+%
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
R436
Product name
VitaminB1
Packaging
1g
Price
$98
Updated
2021/12/16
Matrix Scientific
Product number
097639
Product name
3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride
Purity
95+%
Packaging
5g
Price
$180
Updated
2021/12/16
Matrix Scientific
Product number
097639
Product name
3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride
Purity
95+%
Packaging
10g
Price
$300
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
VIT0000771
Product name
VITAMIN B1
Purity
95.00%
Packaging
5MG
Price
$450.78
Updated
2021/12/16
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Thiamine chloride Chemical Properties,Usage,Production

Originator

Thiamine chloride,Sopharma

Uses

Vitamin B1 is used in method for cultivating tremella strain. Also, it is protein compound liquid comprising collagen and Rhodiola rosea extract or preparing injection to remove skin wrinkle.

Definition

ChEBI: Thiamine(1+) chloride is a vitamin B1 and an organic chloride salt. It contains a thiamine(1+).

Manufacturing Process

2 Methods of preparation of thiamine:
1. 3-Ethoxypropionitrile reacted with diethoxymethoxy-ethane and 3-ethoxy- 2-methoxymethylenpropionitrile was obtained.
Then to the 3-ethoxy-2-methoxymethylenpropionitrile acetamidine was added and reaction mixture was stirred to give 4-amino-5-ethoxy-methyl-2- methylpyrimidine.
The 4-amino-5-ethoxy-methyl-2-methylpyrimidine was treated by hydrobromic acid to afford 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide.
The 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide reacted with 5-(2-hydroxyethyl)-4-methylthiazole in the presence of hydrobromic acid and as the result thiaminbromide was produced. For changing of the thiaminbromide to the thiamincloride the thiaminbromide was treated by AgCl.
2. To diethoxymethoxy-ethane malononitrile was added and ethoxymethylenmalononitrile was obtained. The ethoxymethylen-malononitrile reacted with acetamidine as a result 4-amino-5-cyano-2-methylpyrimidine was produced, which was reduced by H2/Raney-Ni to 4-amino-5-aminomethyl-2- methylpyrimidine.
To the 4-amino-5-aminomethyl-2-methylpyrimidine 1-acetoxy-3-chloropentan- 4-one was added in the presence CS2 and NH3, and reaction mixture was stirred, then to this mixture hydrochloric acid was added and thiamin (base) was obtained.
To thiamin (base) H2O2 and hydrocloricum acid are added, in the result reaction the thiamine chloride was obtained.

Therapeutic Function

Enzyme cofactor vitamin, Antineuritic

General Description

Thiamine, the preferred name for vitamin B1, holds a prominent place in the history of vitamin discovery because beriberi, the disease resulting from insufficient thiamine intake, was one of the earliest recognized deficiency diseases.

Biological Activity

Some earlier designations for this substance included aneurin, antineuritic factor, antiberiberi factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP).
TPP functions as a coenzyme which participates in decarboxylation of α-keto acids. Dehydrogenation and decarboxylation must precede the formation of “active acetate” in the initial reaction of the TCA cycle (citric acid cycle):

This reaction is a good example of the interrelationship of vitamin B coenzymes. Four vitamin coenzymes are necessary for this one reaction: (1) thiamine (in TPP) for decarboxylation; (2) nicotinic acid in nicotinamide adenine dinucleotide (NAD); (3) riboflavin in flavin adenine dinucleotide (FAD); and (4) pantothenic acid in coenzyme A (CoA) for activation of the acetate fragment.

Clinical Use

Thiamine chloride, as the base or as the hydrochloride salt, is indicatedin the treatment or prophylaxis of known or suspected thiaminedeficiencies. Severe thiamine deficiency is calledberiberi, which is very rare in developed countries. The mostlikely cause of thiamine deficiency in the United States is theresult of chronic alcoholism, which leads to multiple vitamindeficiencies as a result of poor dietary intake. The major organsaffected are the nervous system (dry beriberi), whichmanifests as neurological damage, the cardiovascular system(wet beriberi), which manifests as heart failure and edema, andthe gastrointestinal tract. Thiamine administration reverses thegastrointestinal, cardiovascular, and neurological symptoms;however, if the deficiency has been severe or of prolonged duration, the neurological damage may be permanent.

Safety Profile

Poison by subcutaneous and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Cl-.

Thiamine chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Thiamine chloride Suppliers

Hebei chuangzhiyuan biotechnology co., LTD
Tel
13012111162
Email
2792365312@qq.com
Country
China
ProdList
746
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58
Shandong Yatu Biotechnology Co. LTD
Tel
0531-55555418 15301096991
Email
811301959@qq.com
Country
China
ProdList
565
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58
Fujian Shengshi Jiatai Pharmaceutical Co., Ltd
Tel
15396663730
Email
2377044029@qq.com
Country
China
ProdList
1657
Advantage
58
Hubei Hongjing Chemical Co., Ltd.
Tel
027-82333386 13669024603
Fax
86-027-82333386
Email
617019505@qq.com
Country
China
ProdList
276
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58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
6471
Advantage
55
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
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60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
400-9903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18737
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
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View Lastest Price from Thiamine chloride manufacturers

Nantong Guangyuan Chemicl Co,Ltd
Product
Vitamin B1 59-43-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-12-08
Nantong Guangyuan Chemicl Co,Ltd
Product
Vitamin B1 59-43-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-12-04
shandong perfect biotechnology co.ltd
Product
Vitamin B1 59-43-8
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1000kg
Release date
2023-08-04

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