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Thiamine chloride

Product Name
Thiamine chloride
CAS No.
59-43-8
Chemical Name
Thiamine chloride
Synonyms
b-amin;beivon;Betamin;Biamine;weissb1;thiamin;Beta-Sol;Metatone;Thiacoat;aneurine
CBNumber
CB0154385
Molecular Formula
C12H17ClN4OS
Formula Weight
300.81
MOL File
59-43-8.mol
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Thiamine chloride Property

Melting point:
248 °C (decomp)
Density 
1.3175 (rough estimate)
refractive index 
1.5630 (estimate)
CAS DataBase Reference
59-43-8(CAS DataBase Reference)
EPA Substance Registry System
Thiamine (59-43-8)
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Safety

Hazardous Substances Data
59-43-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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Thiamine chloride Chemical Properties,Usage,Production

Originator

Thiamine chloride,Sopharma

Manufacturing Process

2 Methods of preparation of thiamine:
1. 3-Ethoxypropionitrile reacted with diethoxymethoxy-ethane and 3-ethoxy- 2-methoxymethylenpropionitrile was obtained.
Then to the 3-ethoxy-2-methoxymethylenpropionitrile acetamidine was added and reaction mixture was stirred to give 4-amino-5-ethoxy-methyl-2- methylpyrimidine.
The 4-amino-5-ethoxy-methyl-2-methylpyrimidine was treated by hydrobromic acid to afford 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide.
The 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide reacted with 5-(2-hydroxyethyl)-4-methylthiazole in the presence of hydrobromic acid and as the result thiaminbromide was produced. For changing of the thiaminbromide to the thiamincloride the thiaminbromide was treated by AgCl.
2. To diethoxymethoxy-ethane malononitrile was added and ethoxymethylenmalononitrile was obtained. The ethoxymethylen-malononitrile reacted with acetamidine as a result 4-amino-5-cyano-2-methylpyrimidine was produced, which was reduced by H2/Raney-Ni to 4-amino-5-aminomethyl-2- methylpyrimidine.
To the 4-amino-5-aminomethyl-2-methylpyrimidine 1-acetoxy-3-chloropentan- 4-one was added in the presence CS2 and NH3, and reaction mixture was stirred, then to this mixture hydrochloric acid was added and thiamin (base) was obtained.
To thiamin (base) H2O2 and hydrocloricum acid are added, in the result reaction the thiamine chloride was obtained.

Therapeutic Function

Enzyme cofactor vitamin, Antineuritic

General Description

Thiamine, the preferred name for vitamin B1, holds a prominent place in the history of vitamin discovery because beriberi, the disease resulting from insufficient thiamine intake, was one of the earliest recognized deficiency diseases.

Biological Activity

Some earlier designations for this substance included aneurin, antineuritic factor, antiberiberi factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP).
TPP functions as a coenzyme which participates in decarboxylation of α-keto acids. Dehydrogenation and decarboxylation must precede the formation of “active acetate” in the initial reaction of the TCA cycle (citric acid cycle):图
This reaction is a good example of the interrelationship of vitamin B coenzymes. Four vitamin coenzymes are necessary for this one reaction: (1) thiamine (in TPP) for decarboxylation; (2) nicotinic acid in nicotinamide adenine dinucleotide (NAD); (3) riboflavin in flavin adenine dinucleotide (FAD); and (4) pantothenic acid in coenzyme A (CoA) for activation of the acetate fragment.

Clinical Use

Thiamine chloride, as the base or as the hydrochloride salt, is indicatedin the treatment or prophylaxis of known or suspected thiaminedeficiencies. Severe thiamine deficiency is calledberiberi, which is very rare in developed countries. The mostlikely cause of thiamine deficiency in the United States is theresult of chronic alcoholism, which leads to multiple vitamindeficiencies as a result of poor dietary intake. The major organsaffected are the nervous system (dry beriberi), whichmanifests as neurological damage, the cardiovascular system(wet beriberi), which manifests as heart failure and edema, andthe gastrointestinal tract. Thiamine administration reverses thegastrointestinal, cardiovascular, and neurological symptoms;however, if the deficiency has been severe or of prolonged duration, the neurological damage may be permanent.

Safety Profile

Poison by subcutaneous and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Cl-.

Thiamine chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Thiamine chloride Suppliers

Hebei chuangzhiyuan biotechnology co., LTD
Tel
13012111162
Email
2792365312@qq.com
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CHINA
ProdList
748
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58
Nanjing songguan Biotechnology Co., Ltd.
Tel
025-52168336
Fax
025-52168336
Email
2714748392@qq.com
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China
ProdList
675
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58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
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China
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2214
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Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
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China
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3393
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BeiJing Hwrk Chemicals Limted
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010-57411839-
Fax
021-55236763
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bjsales@hwrkchemical.com
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China
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18708
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Beijing Ouhe Technology Co., Ltd
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010-82967028-
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+86-10-82967029
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2355560935@qq.com
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China
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12365
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Adamas Reagent, Ltd.
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400-600-9262
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bxy@titansci.com
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China
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13918
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
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info@chemlin.com.cn
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China
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19993
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XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Fax
QQ: 1791901229
Email
1791901229@qq.com;1791901229@qq.com;
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China
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Chengdu XiYa Chemical Technology Co., Ltd.
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;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10576
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View Lastest Price from Thiamine chloride manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Thiamine chloride 59-43-8
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-26
career henan chemical co
Product
Thiamine chloride 59-43-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 657
Release date
2019-09-01

59-43-8, Thiamine chlorideRelated Search:


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