2-Acetylbutyrolactone
Description Reference- Product Name
- 2-Acetylbutyrolactone
- CAS No.
- 517-23-7
- Chemical Name
- 2-Acetylbutyrolactone
- Synonyms
- ABL;3-acetyldihydrofuran-2(3H)-one;ABL1;ACETYLBUTYROLACTONE;2-Acetylbutyrolacton;-Acetyl-hydroxybutyricacid;2-Oxo-3-acetyltetrahydrofuran;JTK7;p190;bcr/abl
- CBNumber
- CB8101532
- Molecular Formula
- C6H8O3
- Formula Weight
- 128.13
- MOL File
- 517-23-7.mol
2-Acetylbutyrolactone Property
- Melting point:
- <25 °C
- Boiling point:
- 107-108 °C5 mm Hg(lit.)
- Density
- 1.19 g/mL at 25 °C(lit.)
- vapor pressure
- 0.131Pa at 20℃
- refractive index
- n20/D 1.459(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 200g/l
- pka
- 12.00±0.20(Predicted)
- form
- Liquid
- color
- Clear
- biological source
- human
- Water Solubility
- 310 g/L (20 ºC)
- Merck
- 14,83
- Specific Activity
- 717-971nmol/min·mg
- BRN
- 112676
- Stability:
- Stable. Incompatible with strong oxidizing agents, strong bases.
- LogP
- -0.43 at 22℃
- CAS DataBase Reference
- 517-23-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 2(3H)-Furanone, 3-acetyldihydro-(517-23-7)
- EPA Substance Registry System
- 2(3H)-Furanone, 3-acetyldihydro- (517-23-7)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-61
- Safety Statements
- 26-36-37/39-45-53
- WGK Germany
- 1
- RTECS
- LU3456000
- TSCA
- Yes
- HS Code
- 29322980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A13409
- Product name
- α-Acetylbutyrolactone
- Purity
- ≥99%
- Packaging
- 100g
- Price
- $41.1
- Updated
- 2024/03/01
- Product number
- A13409
- Product name
- α-Acetylbutyrolactone
- Purity
- ≥99%
- Packaging
- 500g
- Price
- $45.4
- Updated
- 2024/03/01
- Product number
- A0608
- Product name
- ABL1 (27-end), active, His-tagged from mouse
- Purity
- PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 10μG
- Price
- $522
- Updated
- 2024/03/01
- Product number
- SRP5279
- Product name
- ABL1, active, His tagged human
- Purity
- PRECISIO?, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 10μG
- Price
- $498
- Updated
- 2023/06/20
- Product number
- A0681
- Product name
- alpha-Acetyl-gamma-butyrolactone
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $23
- Updated
- 2024/03/01
2-Acetylbutyrolactone Chemical Properties,Usage,Production
Description
It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4
Reference
- Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
- Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
- Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
- Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.
Chemical Properties
Colorless to light yellow liqui
Uses
An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.
Uses
In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.
Definition
ChEBI: 3-Acetyldihydro-2(3H)-furanone is a gamma-lactone.
Flammability and Explosibility
Not classified
2-Acetylbutyrolactone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Acetylbutyrolactone manufacturers
- Product
- 2-Acetylbutyrolactone 517-23-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000mt
- Release date
- 2022-02-17
- Product
- 2-Acetylbutyrolactone 517-23-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1500 TONS
- Release date
- 2024-03-29
- Product
- 2-Acetylbutyrolactone 517-23-7
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 500KG/Month
- Release date
- 2024-09-18