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2-Acetylbutyrolactone

Description Reference
Product Name
2-Acetylbutyrolactone
CAS No.
517-23-7
Chemical Name
2-Acetylbutyrolactone
Synonyms
ABL;3-acetyldihydrofuran-2(3H)-one;ABL1;ACETYLBUTYROLACTONE;2-Acetylbutyrolacton;-Acetyl-hydroxybutyricacid;2-Oxo-3-acetyltetrahydrofuran;JTK7;p190;bcr/abl
CBNumber
CB8101532
Molecular Formula
C6H8O3
Formula Weight
128.13
MOL File
517-23-7.mol
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2-Acetylbutyrolactone Property

Melting point:
<25 °C
Boiling point:
107-108 °C5 mm Hg(lit.)
Density 
1.19 g/mL at 25 °C(lit.)
vapor pressure 
0.131Pa at 20℃
refractive index 
n20/D 1.459(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
200g/l
form 
Liquid
pka
12.00±0.20(Predicted)
color 
Clear
Water Solubility 
310 g/L (20 ºC)
Merck 
14,83
BRN 
112676
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
LogP
-0.43 at 22℃
CAS DataBase Reference
517-23-7(CAS DataBase Reference)
NIST Chemistry Reference
2(3H)-Furanone, 3-acetyldihydro-(517-23-7)
EPA Substance Registry System
2(3H)-Furanone, 3-acetyldihydro- (517-23-7)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-61
Safety Statements 
26-36-37/39-45-53
WGK Germany 
1
RTECS 
LU3456000
TSCA 
Yes
HS Code 
29322980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A13409
Product name
α-Acetylbutyrolactone
Purity
≥99%
Packaging
100g
Price
$41.1
Updated
2024/03/01
Sigma-Aldrich
Product number
A13409
Product name
α-Acetylbutyrolactone
Purity
≥99%
Packaging
500g
Price
$45.4
Updated
2024/03/01
Sigma-Aldrich
Product number
A0608
Product name
ABL1 (27-end), active, His-tagged from mouse
Purity
PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging
10μG
Price
$522
Updated
2024/03/01
Sigma-Aldrich
Product number
SRP5279
Product name
ABL1, active, His tagged human
Purity
PRECISIO?, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging
10μG
Price
$498
Updated
2023/06/20
TCI Chemical
Product number
A0681
Product name
alpha-Acetyl-gamma-butyrolactone
Purity
>99.0%(GC)
Packaging
25g
Price
$23
Updated
2024/03/01
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2-Acetylbutyrolactone Chemical Properties,Usage,Production

Description

It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4

Reference

  1. Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
  2. Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
  3. Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
  4. Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.

Chemical Properties

Colorless to light yellow liqui

Uses

An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.

Uses

In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.

Definition

ChEBI: 3-Acetyldihydro-2(3H)-furanone is a gamma-lactone.

Flammability and Explosibility

Not classified

2-Acetylbutyrolactone Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Acetyl ketene ETHYLENE OXIDE Methyl acetoacetate Vinyl acetate Sodium hydroxide METHANE Gamma Butyrolactone

Preparation Products

Thiamine chloride 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Fursultiamine
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View Lastest Price from 2-Acetylbutyrolactone manufacturers

Jinan Finer Chemical Co., Ltd
Product
2-Acetylbutyrolactone 517-23-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000mt
Release date
2022-02-17
BLiT (Hefei)Chemical Co.,Ltd
Product
2-Acetylbutyrolactone 517-23-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1500 TONS
Release date
2024-03-29
Henan Fengda Chemical Co., Ltd
Product
2-Acetylbutyrolactone 517-23-7
Price
US $6.00-0.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-18

517-23-7, 2-AcetylbutyrolactoneRelated Search:

N-ACETYL-L-TYROSINE ETHYL ESTER Acetyl coenzyme A sodium salt Dihydromyrcenol Acetylacetone Acetyl chloride tributyl acetocitrate Gamma Butyrolactone ALPHA-ACETYL-ALPHA-METHYL-GAMMA-BUTYROLACTONE Iragon Blue ABL9 ABL PROTEIN TYROSINE KINASE,ABL PROTEIN TYROSINE KINASE, RECOMBINANT, E COLI ABL-21 butalactin OXO-(2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID ETHYL ESTER Dihydro-3-(3-pyridoyl)-2-(3H)-furanone okilactomycin SETOSUSIN 2-CHLOROACETYL BUTYROLACTONE RK-682

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  • NSC 2019
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  • Anti-Abl-interactor protein 1
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  • Anti-interactor protein AblBP4
  • Anti-Nap1 binding protein NAP1BP
  • Anti-spectrin SH3 domain binding protein 1 SSH3BP1
  • ABL1, active, His tagged human
  • bcr/abl
  • ABL1 (27-end), active, His-tagged from mouse
  • ANTI-C ABL (ABL1)(C-TERMINAL) antibody produced in rabbit
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  • Abelson murine leukemia viral oncogene homolog 1
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