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Riboflavin 5'-Monophosphate Sodium Salt

Description References
Product Name
Riboflavin 5'-Monophosphate Sodium Salt
CAS No.
130-40-5
Chemical Name
Riboflavin 5'-Monophosphate Sodium Salt
Synonyms
Ribo;Hyryl;Cytoflav;93.0%(E);Flamotide;Sodium FMN;Coflavinase;Riboflavine-5';FMN SODIUM SALT;VITAMIN B2-PHOSPHATE
CBNumber
CB4472478
Molecular Formula
C17H20N4NaO9P
Formula Weight
478.33
MOL File
130-40-5.mol
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Riboflavin 5'-Monophosphate Sodium Salt Property

Melting point:
>300°C
alpha 
[α]D20 +38~+43° (c=1.5, dil. HCl) (Calculated on dehydrous basis)
FEMA 
2976 | QUININE HYDROCHLORIDE
refractive index 
41 ° (C=1.5, 5mol/L HCl)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL, clear, orange
form 
powder
optical activity
[α]20/D +37 to +42°, c = 1.5 in 5 M HCl(lit.)
Water Solubility 
almost transparency
Merck 
14,8201
BRN 
4106529
Stability:
Stable. Incompatible with strong oxidizing agents, reducing agents, bases, calcium, metallic salts. Protect from light, air and moisture.
CAS DataBase Reference
130-40-5(CAS DataBase Reference)
EPA Substance Registry System
Riboflavin 5'-(dihydrogen phosphate), monosodium salt (130-40-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
22-24/25-37/39-26
WGK Germany 
3
3-8-10
HS Code 
29362300
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F1392
Product name
Riboflavin 5′-monophosphate sodium salt hydrate
Purity
≥70%
Packaging
25mg
Price
$69
Updated
2021/12/16
Sigma-Aldrich
Product number
77623
Product name
Riboflavin 5′-monophosphate sodium salt
Purity
tested according to Ph.Eur.
Packaging
50g-f
Price
$221
Updated
2021/12/16
Sigma-Aldrich
Product number
77623
Product name
Riboflavin 5′-monophosphate sodium salt
Purity
tested according to Ph. Eur.
Packaging
50 g
Price
$229
Updated
2021/12/16
Sigma-Aldrich
Product number
F6750
Product name
Riboflavin 5′-monophosphate sodium salt hydrate
Purity
73-79% (fluorimetric)
Packaging
100g
Price
$257
Updated
2018/11/20
Sigma-Aldrich
Product number
F6750
Product name
Riboflavin 5′-monophosphate sodium salt hydrate
Purity
73-79% (fluorimetric)
Packaging
25g
Price
$101
Updated
2018/11/20
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Riboflavin 5'-Monophosphate Sodium Salt Chemical Properties,Usage,Production

Description

Riboflavin-5-phosphate sodium (sodium FMN) consist mainly monosodium salt of Riboflavin 5-phophate (FMN), the 5-monophosphate ester of riboflavin. Riboflavin-5-phosphate sodium is produced by direct reaction of riboflavin with a phosphorylating agent such as phosphorous oxychloride in an organic solvent.
Riboflavin 5-phophate (FMN) is essential as a coenzyme in various enzymic reactions in the body and is therefore used in the form of its salts, especially in the form of sodium FMN, as additive to drugs and human and animal food. Sodium FMN is also used as starting material for flavin adenine dinucleotide which is employed for treating vitamin B2 deficiency. It is used as a yellow food color additive (E106).  Riboflavin 5-phosphate sodium is fairly stable in air but is hygroscopic and sensitive to heat and light. The product may be stored for 33 months from the date of manufacture in the unopened original container and at a temperature below 15 °C.

References

[1] https://en.wikipedia.org/wiki/Flavin_mononucleotide
[2] Scientific Opinion on the re-evaluation of riboflavin (E101(i)) and riboflavin-5’-phosphate sodium (E 101(ii)) as food additives, EFSA Journal 2013
[3] Patent US 5095115A: Preparation of riboflavin 5'-phosphate (fmn) and its sodium salt in a lactone

Chemical Properties

Riboflavin 5'-Monophosphate Sodium Salt is a yellow toorange-yellow, crystalline hygroscopic powder. It is odorless, and has a slightly bitter taste.

It is soluble in water, and practically insoluble in ethanol(95), in chloroform and in diethyl ether.
It is decomposed on exposure to light.

Uses

One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).

Uses

antibacterial.
Riboflavin 5′-monophosphate sodium salt was used as water-soluble model drug in a combined conventional inkjet printing technology with flexographic printing for the fabrication of drug delivery systems.It may be employed as initiator for the photo-initiated polymerization of acrylamide.It may be employed in chronoamperometric assay for vanadium ions.
Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF).Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide.

Uses

Riboflavin 5′-monophosphate sodium salt hydrate has been used:
  • as a component of assay buffer to determine the luminescence of L. lactis cells
  • as a component of the reaction mixture in nitric oxide synthase (NOS) enzymatic activity assay
  • in the high performance liquid chromatography (HPLC) analysis of Flavin mononucleotide (FMN) cyclase products
  • in luciferase assay with firefly luciferase

Biological Functions

Riboflavin 5'-Phosphate Sodium is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes. Riboflavin phosphate sodium is converted to 2 coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are necessary for energy production by aiding in the metabolism of fats, carbohydrates and proteins and are required for red blood cell formation and respiration, antibody production and for regulating human growth and reproduction. Riboflavin phosphate sodium is essential for healthy skin, nails and hair growth.

General Description

Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF). Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide.

Biochem/physiol Actions

Riboflavin 5′-monophosphate or flavin mononucleotide (FMN) possesses fluorescence, photosensitivity and redox activities.

Purification Methods

Purify FMN by paper chromatography using tert-butanol/water, cutting out the main spot and eluting it with water. It can also be purified by adsorption onto an apo-flavodoxin column, followed by elution and freeze drying. It crystallises from aqueous acidic solution. [Mayhew & Strating Eur J Biochem 59 539 1976, Beilstein 26 III/IV 2555.]

Riboflavin 5'-Monophosphate Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Riboflavin 5'-Monophosphate Sodium Salt Suppliers

Hubei widely chemical technology Co., Ltd.
Tel
027-83778895-
Fax
027-51119224
Email
18602735115@163.com
Country
China
ProdList
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Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ:2779667926
Email
buy@fortunachem.com
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China
ProdList
1281
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
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China
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40264
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future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
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China
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
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Energy Chemical
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021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43431
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Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
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64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
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50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
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View Lastest Price from Riboflavin 5'-Monophosphate Sodium Salt manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Riboflavin 5'-Monophosphate Sodium Salt 130-40-5
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-03
Hebei Yime New Material Technology Co., Ltd.
Product
Vitamin B2 Riboflavin Sodium 130-40-5
Price
US $260.00/KG
Min. Order
1000KG
Purity
99
Supply Ability
1000
Release date
2021-11-23
Hebei Yirun Sega Biological Technology Co. Ltd
Product
Riboflavin sodium phosphate 130-40-5
Price
US $250.00/KG
Min. Order
100KG
Purity
99.9%
Supply Ability
100tons
Release date
2021-11-10

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