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Calcium phosphate

Product Name
Calcium phosphate
CAS No.
7758-87-4
Chemical Name
Calcium phosphate
Synonyms
calcium phosphate,tertiary;calciumphosphate(ca3(po4)2);C08136;bonarka;synthos;KH2PO14;tricalcium;β-phase basis;cium phosphate;Calciumphosphat
CBNumber
CB3125692
Molecular Formula
Ca3O8P2
Formula Weight
310.18
MOL File
7758-87-4.mol
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Calcium phosphate Property

Melting point:
1670°C
Density 
3.14
refractive index 
1.63
FEMA 
3081 | TRICALCIUM PHOSPHATE
storage temp. 
room temp
solubility 
Practically insoluble in water. It dissolves in dilute hydrochloric acid and in dilute nitric acid.
form 
aqueous suspension
color 
White
PH
6-8 (50g/l, H2O, 20°C) suspension
Odor
Odorless
Water Solubility 
0.1 g/L (25 ºC)
Merck 
13,1699
Solubility Product Constant (Ksp)
pKsp: 28.68
Cosmetics Ingredients Functions
ORAL CARE
ABRASIVE
ANTICAKING
FRAGRANCE
OPACIFYING
Cosmetic Ingredient Review (CIR)
Calcium phosphate (7758-87-4)
InChI
1S/3Ca.2H3O4P/c;;;2*1-5(2,3)4/h;;;2*(H3,1,2,3,4)/q3*+2;;/p-6
InChIKey
QORWJWZARLRLPR-UHFFFAOYSA-H
SMILES
[Ca+2].[Ca+2].[Ca+2].[P](=O)([O-])([O-])[O-].[P](=O)([O-])([O-])[O-]
LogP
-2.15
CAS DataBase Reference
7758-87-4(CAS DataBase Reference)
EPA Substance Registry System
Tricalcium phosphate (7758-87-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
WGK Germany 
3
TSCA 
TSCA listed
HS Code 
2835 26 00
Storage Class
11 - Combustible Solids
Hazardous Substances Data
7758-87-4(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
50553
Product name
α-Tri-Calcium phosphate
Purity
Reagentfortransient&stableDNAtransfections
Packaging
1g
Price
$174
Updated
2025/07/31
Sigma-Aldrich
Product number
50553
Product name
α-Tri-Calcium phosphate
Purity
Reagentfortransient&stableDNAtransfections
Packaging
10g
Price
$822
Updated
2025/07/31
Sigma-Aldrich
Product number
13204
Product name
β-tri-Calcium phosphate
Purity
puriss. p.a., ≥98% β-phase basis (unsintered powder)
Packaging
10g
Price
$266
Updated
2025/07/31
Sigma-Aldrich
Product number
1.02143
Product name
Calcium phosphate
Purity
dried EMPROVE? ESSENTIAL Ph Eur,BP,E 341 (iii)
Packaging
1kg
Price
$365
Updated
2025/07/31
Sigma-Aldrich
Product number
1.02143
Product name
Calcium phosphate
Purity
dried EMPROVE? ESSENTIAL Ph Eur,BP,E 341 (iii)
Packaging
25kg
Price
$1067
Updated
2025/07/31
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Calcium phosphate Chemical Properties,Usage,Production

Description

Calcium Phosphate is the calcium salt of phosphoric acid with widely used applications. It occur abundantly in nature in several forms and are the principal minerals for the production of phosphate fertilizers and for a range of phosphorus compounds. For example, the tribasic variety (precipitated calcium phosphate), Ca3(PO4)2, is the principal inorganic constituent of bone ash. The acid salt Ca(H2PO4)2, produced by treating mineral phosphates with sulfuric acid, is employed as a plant food and stabilizer for plastics. It is a natural constituent of mammals, and it is a component of bone replacement transplants in much higher amounts with no toxicological problems.

Calcium phosphates are the largest group of artificial bone graft substitutes. This is mainly due to their close resemblance to the mineral components of bone. This Product can be used as a countermeasure for exposure to strontium and radium radionuclides. Upon oral uptake, calcium phosphate competes for and blocks the absorption of radium (Ra-226) and strontium (Sr-90) in the gastrointestinal (GI) tract.

Chemical Properties

Calcium phosphate, also known as tricalcium phosphate, is a white or almost white powder that is insoluble in water. It reacts with silicon oxide and carbon at electric furnace temperatures to yield phosphorus vapor. When reacted with sulfuric acid (H₂SO₄), it forms different products depending on the proportions used: phosphoric acid, dicalcium hydrogen phosphate (CaHPO₄, a white insoluble solid), or calcium dihydrogen phosphate (Ca(H₂PO₄)₂·H₂O, a white soluble solid). Its solubility product constant (Ksp) is 28.70.

Physical properties

White amorphous powder; refractive index 1.63; density 3.14 g/cm3; melts at 1,670°C; insoluble in water; KSP 1.0x10-25; soluble in acids.

Occurrence

Tribasic calcium phosphate occurs in nature as minerals, such as oxyapatite, whitlockite, voelicherite, apatite, and phosphorite. It has many industrial applications, some of which are similar to those of the monobasic and dibasic salts. It is used in fertilizers, dental products, ceramics, and polishing powder. 

Other important applications include its use: As a stabilizer in plastics; As an anticaking agent; As a nutrient supplement in cattle feed; For clarifying sugar syrup; As a mordant in dyeing textiles; And as a buffer to control pH.

Uses

Calcium Phosphate is an anticaking agent and calcium source that is a white powder that is almost insoluble in water. It is used as an anticaking agent in table salt and dry vinegar. It is used as a source of calcium and phosphorus in cereals and desserts. It functions as a bleaching agent in flour and in lard, and prevents undesirable coloring and improves stability for frying. It is also termed tribasic calcium phosphate, tricalcium orthophosphate, calcium phosphate tribasic, and precipitated calcium phosphate.

Preparation

Tribasic calcium phosphate is obtained from naturally occurring minerals for fertilizer applications. The compound may be prepared in the laboratory by the reaction of sodium phosphate with calcium chloride with excess of ammonia. Also, it can be prepared by treatment of calcium hydroxide with phosphoric acid:
2H3PO4 + 3Ca(OH)2 → Ca3(PO4)2 + 6H2O

Definition

ChEBI: Tricalcium bis(phosphate) is a calcium phosphate.

Application

Calcium Phosphate (Ca3(PO4)2) is an ionic compound that exists in several forms, including monobasic, dibasic, and tribasic calcium phosphate.
Monobasic calcium phosphate, also termed monocalcium phosphate, calcium biphosphate, or acid calcium phosphate, is used as a leavening agent and acidulant.
Dibasic calcium phosphate, also termed dicalcium phosphate dihydrate, is used as a dough conditioner and mineral supplement.
Tribasic calcium phosphate, also termed tricalcium phosphate or precipitated calcium phosphate, is used as an anticaking agent, mineral supplement, and conditioning agent.
Calcium phosphate is used in the manufacture of fertilizers, H₃PO₄ (phosphoric acid), and other phosphorus compounds. It is also used in the production of milk-glass, polishing powders, dental powders, porcelains, and pottery; in enameling; for clarifying sugar syrups; in animal feeds as a mineral supplement; as an anticaking agent; and in the textile industry.[2]

General Description

β-tri-Calcium phosphate belongs to the category of calcium-phosphate based ceramics, which has been involved in the preparation of a new biosynthetic material possessing morphogenetic activity that is used as a bone implant.

Flammability and Explosibility

Non flammable

Industrial uses

Calcium phosphate [Ca3(PO4)2] finds applications as a supplement for animal feed, as a fertiliser, in the manufacture of glass and in dental products.

References

[1] SHALINI THOMAS   Balakumar S  Ajay Rakkesh Rajendran. Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro-angiogenic properties[J]. Journal of biomedical materials research. Part B, Applied biomaterials, 2022, 111 4: 858-871. DOI:10.1002/jbm.b.35196.
[2] F. Z. ALIYAT. Phosphate-Solubilizing Bacteria Isolated from Phosphate Solid Sludge and Their Ability to Solubilize Three Inorganic Phosphate Forms: Calcium, Iron, and Aluminum Phosphates[J]. Microorganisms, 2022. DOI:10.3390/microorganisms10050980.

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Calcium phosphate Suppliers

Lingshin (Lianyungang) Technology Co., Ltd.
Tel
518-8515-7007 15305138251
Email
jax@lingshin.com
Country
China
ProdList
21
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58
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Shandong Changsheng Environmental Protection Technology Development Co., Ltd
Tel
18806405108
Email
1051319044@qq.com
Country
China
ProdList
99
Advantage
58
hengzhou Ruipu Biological Engineering Co.,Ltd
Tel
0371-67896358 18939518519
Email
1792162307@qq.com
Country
China
ProdList
49
Advantage
58
Jinan Rongxin Chemical Technology Co., Ltd
Tel
13365316808 15215418789
Email
1726419589@qq.con
Country
China
ProdList
59
Advantage
58
Tianjin Jinhui Taiya Chemical Reagent Co., Ltd
Tel
022-59582624 18622766592
Email
2163746375@qq.com
Country
China
ProdList
270
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9411
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
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View Lastest Price from Calcium phosphate manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
Tricalcium Phosphate 7758-87-4
Price
US $1200.00-1100.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000T/M
Release date
2025-09-18
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Calcium phosphate 7758-87-4
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-31
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Calcium phosphate 7758-87-4
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-18

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