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Sodium Phosphate Monobasic Monohydrate

Product Name
Sodium Phosphate Monobasic Monohydrate
CAS No.
10049-21-5
Chemical Name
Sodium Phosphate Monobasic Monohydrate
Synonyms
PHOSPHATE BUFFER;Sodium dihydrogen phosphate monohydrate;POTASSIUM PHOSPHATE BUFFER;Phosphate buffered;RIA BUFFER;PH 7 BUFFER;BUFFER FOR BOD;BUFFER MDB 9.50;Dilution bottle;diltuion bottles
CBNumber
CB5158267
Molecular Formula
H4NaO5P
Formula Weight
137.992291
MOL File
10049-21-5.mol
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Sodium Phosphate Monobasic Monohydrate Property

Melting point:
100°C -H₂O
Boiling point:
399 °C
Density 
2,04 g/cm3
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 1 M, clear, colorless
form 
Solid
color 
White semi-transparentor
PH
4.1-4.5 (25℃, 50mg/mL in H2O)
Odor
Odorless
PH Range
4.1 - 4.5 at 50 g/l at 25 °C
Water Solubility 
Soluble in water; insoluble in ethanol, ether and chloroform.
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Merck 
14,8660
InChIKey
BBMHARZCALWXSL-UHFFFAOYSA-M
LogP
-2.148 (est)
CAS DataBase Reference
10049-21-5(CAS DataBase Reference)
EPA Substance Registry System
Monosodium phosphate monohydrate (10049-21-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36/37/39-36-39-24/25
WGK Germany 
1
RTECS 
WA1900000
3
TSCA 
Yes
HS Code 
2835 22 00
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 7940 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Z699470
Product name
Dilution bottle
Purity
Butterfield′s Buffer, volume 90?mL
Packaging
72ea
Price
$151
Updated
2024/03/01
Sigma-Aldrich
Product number
8290-OP
Product name
OmniPur Sodium Phosphate, Monobasic, Monohydrate - CAS 10049-21-5 - Calbiochem
Packaging
500g
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
567549
Product name
Sodium Phosphate, Monobasic, Monohydrate, Molecular Biology Grade - CAS 10049-21-5 - Calbiochem
Purity
Useful in conjunction with Sodium Phosphate, Dibasic in the preparation of biological buffers.
Packaging
250g
Price
$79.8
Updated
2024/03/01
Sigma-Aldrich
Product number
567545
Product name
Sodium Phosphate, Monobasic - CAS 10049-21-5 - Calbiochem
Purity
ACS Reagent Grade. Useful in conjunction with Sodium Phosphate, Dibasic in the preparation of biological buffers.
Packaging
500g
Price
$97
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37093
Product name
Sodium dihydrogen phosphate monohydrate
Purity
EMPROVE? EXPERT BP,USP
Packaging
1kg
Price
$102
Updated
2024/03/01
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Sodium Phosphate Monobasic Monohydrate Chemical Properties,Usage,Production

Description

Sodium Phosphate Monobasic Monohydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures. Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. It is used as sequestrant, emulsifier, mordant in dyeing, reagent and buffer in foods and analytical chemistry. It is applied as a fireproofing agent and for weighting silk in tanning. It is employed in manufacturing of enamels, ceramics, detergents, boiler compounds, in soldering and brazing instead of borax.
Monobasic sodium phosphate is used in baking powders, acid cleansers, electroplating, as a dry acidulant, and in treating boiler water.

Chemical Properties

Anhydrous salt: white crystalline powder; slightly hygroscopic; forms sodium acid pyrophosphate, Na2H2P2O7 on heating above 225°C and sodium metaphosphate (NaPO3)n at about 350 to 400°C; very soluble in water, aqueous solution acidic.
Monohydrate: white orthorhombic crystals or granules; density 2.04 g/cm3 ; loses its water of crystallization at 100°C; very soluble in water, pH of 1% solution 4.5; insoluble in alcohol.
Dihydrate: large transparent crystals; orthorhombic bisphenoidal structure; density 1.915 g/cm 3 ; decomposes at 60°C; very soluble in water; insoluble in alcohol.

Chemical Properties

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Uses

Excipient.

Uses

Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures.

Uses

Sodium phosphate monobasic monohydrate has been used for the preparation of cardioplegia solution. It has also been used as a component in McIlvaine′s buffer and MgCl2 buffer.

Definition

ChEBI: Sodium dihydrogenphosphate monohydrate is a hydrate that is the monohydrate form of sodium dihydrogenphosphate. It contains a sodium dihydrogenphosphate.

Preparation

Monobasic sodium phosphate can be prepared by partial neutralization of phosphoric acid with sodium hydroxide in equimolar amounts:
H3PO4+ NaOH →NaH2PO4+ H2O
It also can be made by treating disodium hydrogen phosphate with phosphoric acid in proper stoichiometric amount:
Na2HPO4+ H3PO4→2NaH2PO4

Production Methods

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

General Description

Useful in conjuction with sodium phosphate, dibasic (Cat. No. 567550) in the preparation of biological buffers(absorbance: ≤0.01 at 260 nm and 280 nm).

Pharmaceutical Applications

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

Safety

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

storage

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

Incompatibilities

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium Phosphate Monobasic Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium Phosphate Monobasic Monohydrate Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
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86-21-61259102
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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Energy Chemical
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Adamas Reagent, Ltd.
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Shandong Xiya Chemical Co., Ltd
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Syntechem Co.,Ltd
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Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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86-21-63290778 86-21-63218885
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sj_scrc@sinopharm.com
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Maya High Purity Chemicals
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+86 (573) 82222445 (0)18006601000 452520369
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+86 (573) 82222643
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View Lastest Price from Sodium Phosphate Monobasic Monohydrate manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Sodium Phosphate Monobasic Monohydrate 10049-21-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-20
Hebei Guanlang Biotechnology Co., Ltd.
Product
Sodium Phosphate Monobasic Monohydrate 10049-21-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2023-03-29
Hebei Mingeng Biotechnology Co., Ltd
Product
Sodium Dihydrogen Phosphate Monohydrate 10049-21-5
Price
US $180.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
500kg/month
Release date
2022-05-05

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